Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ADAMTS-like protease | 0.0034 | 0.1388 | 0.0931 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.2406 | 0.2004 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0503 | 0.0503 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.2406 | 0.2004 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0503 | 0.0503 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0503 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | carboxylesterase | 0.0136 | 1 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0031 | 0.1204 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0136 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.147 | 0.147 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.7752 | 0.7632 |
Echinococcus multilocularis | adam | 0.0031 | 0.1204 | 0.0738 |
Brugia malayi | angiogenesis inhibito | 0.0034 | 0.1388 | 0.0931 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.0503 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0.1204 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0503 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.2406 | 0.2004 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1204 | 0.1204 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.0503 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0136 | 1 | 1 |
Echinococcus granulosus | adam | 0.0031 | 0.1204 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.7752 | 0.7752 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Onchocerca volvulus | Papilin homolog | 0.0035 | 0.147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0503 | 0.0503 |
Echinococcus granulosus | carboxylesterase 5A | 0.0136 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.6 uM | Inhibition of ADAMTS5 | ChEMBL. | 18760922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.