Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0142 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0142 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0142 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0142 | 1 | 0.5 |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0142 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0142 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0142 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0142 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0142 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0142 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0142 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0142 | 1 | 0.5 |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0142 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0142 | 1 | 0.5 |
Onchocerca volvulus | 0.0142 | 1 | 0.5 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0142 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0142 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0142 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0142 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0142 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0142 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of ADAMTS5 | ChEMBL. | 18760922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.