Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 1 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0007 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Brugia malayi | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0007 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.1232 | 0.1232 |
Onchocerca volvulus | 0.0023 | 0.1232 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.1232 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.1232 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.1232 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.1232 | 0.1232 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.1232 | 0.1232 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.1232 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.1232 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.1232 | 0.1232 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0137 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.1232 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.1232 | 0.1232 |
Onchocerca volvulus | 0.0023 | 0.1232 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.1232 | 0.1232 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0137 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.1232 | 0.1232 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.1232 | 0.1232 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0007 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.1232 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.1232 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.1232 | 0.1232 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 1 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.1232 | 0.1232 |
Onchocerca volvulus | 0.0023 | 0.1232 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.1232 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0023 | 0.1232 | 0.1232 |
Mycobacterium leprae | putative cytochrome p450 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.1232 | 0.1232 |
Leishmania major | cytochrome p450-like protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.1232 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0.1232 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1232 | 0.1232 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 10 % | Displacement of [3H]GR-113808 from human 5HT4 isoform E receptor expressed in rat C6 cells at 10 nM by liquid scintillation counting | ChEMBL. | 19334715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.