Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0106 | 0.5512 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2569 | 0.4033 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0106 | 0.5512 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0098 | 0.4873 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2569 | 0.4033 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0098 | 0.4873 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0098 | 0.4873 | 0.4296 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.4873 | 0.4296 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2569 | 0.1732 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0098 | 0.4873 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0106 | 0.5512 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0034 | 0.0181 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2569 | 0.1732 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2569 | 0.4033 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2569 | 0.4033 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.4873 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0098 | 0.4873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.4873 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0106 | 0.5512 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2569 | 0.4033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2569 | 0.1732 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0032 | 0.0069 | 0.0142 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2569 | 0.1732 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.4873 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0106 | 0.5512 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2569 | 0.1732 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0098 | 0.4873 | 0.4296 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.4873 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2569 | 0.1732 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0106 | 0.5512 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0106 | 0.5512 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2569 | 0.1732 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2569 | 0.4033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.