Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutathione reductase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0137 | 0.746 | 1 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0137 | 0.746 | 0.2698 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0137 | 0.746 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0043 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0125 | 0.6521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.8685 | 0.6219 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Brugia malayi | glutathione reductase | 0.0125 | 0.6521 | 0.6521 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0043 | 0 | 0.5 |
Brugia malayi | Sushi domain | 0.0137 | 0.746 | 0.746 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0137 | 0.746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Trypanosoma brucei | trypanothione reductase | 0.0125 | 0.6521 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0125 | 0.6521 | 0.8741 |
Toxoplasma gondii | thioredoxin reductase | 0.0125 | 0.6521 | 0.8741 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0137 | 0.746 | 1 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Plasmodium vivax | apical sushi protein, putative | 0.0137 | 0.746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.746 | 0.2698 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Treponema pallidum | NADH oxidase | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0125 | 0.6521 | 1 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Plasmodium falciparum | thioredoxin reductase | 0.0125 | 0.6521 | 0.8741 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Plasmodium vivax | glutathione reductase, putative | 0.0125 | 0.6521 | 0.8741 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0137 | 0.746 | 1 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | apical sushi protein | 0.0137 | 0.746 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0125 | 0.6521 | 0.6521 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0137 | 0.746 | 1 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.0125 | 0.6521 | 0.8741 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0125 | 0.6521 | 0.8741 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0137 | 0.746 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0125 | 0.6521 | 0.8741 |
Leishmania major | trypanothione reductase | 0.0125 | 0.6521 | 1 |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Onchocerca volvulus | 0.0137 | 0.746 | 0.5 | |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0137 | 0.746 | 0.746 |
Brugia malayi | hypothetical protein | 0.0137 | 0.746 | 0.746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.