Detailed information for compound 995270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.405 | Formula: C18H33NO7P2
  • H donors: 4 H acceptors: 6 LogP: 2.23 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCOc1cc(c[n+](c1)C)CC(P(=O)(O)O)P(=O)(O)[O-]
  • InChi: 1S/C18H33NO7P2/c1-3-4-5-6-7-8-9-10-11-26-17-12-16(14-19(2)15-17)13-18(27(20,21)22)28(23,24)25/h12,14-15,18H,3-11,13H2,1-2H3,(H3-,20,21,22,23,24,25)
  • InChiKey: PUCSJEGLZHMUSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geranylgeranyl diphosphate synthase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania mexicana polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Brugia malayi geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma mansoni geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma congolense Hydroxyneurosporene synthase (CrtC)/Polyprenyl synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania major polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania donovani polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Treponema pallidum octaprenyl-diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Candida albicans geranylgeranyl diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania infantum polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania braziliensis polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum Geranylgeranyl pyrophosphate synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative geranylgeranyl diphosphate synthase 1 300 aa 317 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.073 0.0826 0.1141
Echinococcus granulosus 7TM GPCR rhodopsin 0.0506 0.0554 0.0552
Echinococcus granulosus orexin receptor type 2 0.0506 0.0554 0.0552
Onchocerca volvulus 0.0506 0.0554 0.5212
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0095 0.0053 0.0072
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.6006 0.7245 1
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0001 0.0000072812
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni voltage-gated ion channel 0.0076 0.0031 0.003
Echinococcus granulosus chromatin regulatory protein sir2 0.0109 0.0071 0.007
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0001 0.0002
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0109 0.0071 0.007
Echinococcus multilocularis conserved hypothetical protein 0.0076 0.0031 0.003
Brugia malayi Serotonin receptor 0.0506 0.0554 0.0763
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0054 0.0004 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0205 0.0188 0.0258
Echinococcus multilocularis orexin receptor type 2 0.0506 0.0554 0.0552
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0205 0.0188 0.0187
Loa Loa (eye worm) heat shock protein 75 0.0067 0.0019 0.0027
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0506 0.0554 0.0764
Brugia malayi latrophilin 2 splice variant baaae 0.2339 0.2784 0.3841
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.0071 0.2491
Schistosoma mansoni ephrin receptor 0.0108 0.0069 0.0068
Schistosoma mansoni opsin-like receptor 0.0506 0.0554 0.0552
Trypanosoma cruzi Heat shock protein 83, putative 0.0237 0.0227 1
Onchocerca volvulus 0.0205 0.0188 0.1761
Brugia malayi Protein kinase domain containing protein 0.0071 0.0024 0.0032
Echinococcus multilocularis G-protein coupled receptor, putative 0.0506 0.0554 0.0552
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0506 0.0554 0.0552
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.003
Echinococcus multilocularis allatostatin A receptor 0.0923 0.1061 0.106
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0067 0.0019 0.0018
Echinococcus multilocularis two pore calcium channel protein 2 0.0076 0.0031 0.003
Echinococcus multilocularis voltage gated potassium channel 0.0125 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.1099 0.1275 0.1274
Schistosoma mansoni ryanodine receptor related 0.0076 0.0031 0.003
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0095 0.0053 0.0052
Plasmodium falciparum cysteine repeat modular protein 1 0.0094 0.0052 0.1587
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.0031 0.003
Mycobacterium ulcerans glutaminase 0.0266 0.0262 0.0862
Toxoplasma gondii Hsp90 domain-containing protein 0.0067 0.0019 0.025
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0094 0.0052 0.1587
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Trypanosoma cruzi polyprenyl synthase, putative 0.0127 0.0093 0.3572
Trypanosoma brucei prolyl endopeptidase 0.0146 0.0115 0.3136
Brugia malayi sulfakinin receptor protein 0.0506 0.0554 0.0763
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0111 0.0073 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.0057 0.0007 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Echinococcus granulosus tachykinin peptides receptor 99D 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Echinococcus granulosus potassium voltage gated channel protein 0.0076 0.0031 0.003
Giardia lamblia Hypothetical protein 0.0109 0.0071 0.1471
Brugia malayi Dopamine receptor 0.0506 0.0554 0.0763
Brugia malayi glutaminase DH11.1 0.0266 0.0262 0.0361
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0076 0.0031 0.0279
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0076 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Leishmania major silent information regulator 2, putative 0.0109 0.0071 0.0849
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0506 0.0554 0.0764
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0356 0.0372 0.0512
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0205 0.0188 0.0258
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0205 0.0188 0.0258
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0031 0.0043
Schistosoma mansoni opsin-like receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0506 0.0554 0.0552
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0923 0.1061 0.106
Trypanosoma cruzi heat shock protein 85, putative 0.0237 0.0227 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0506 0.0554 0.0763
Echinococcus granulosus potassium large conductance calcium activated 0.0076 0.0031 0.003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0506 0.0554 0.0552
Brugia malayi Dopamine receptor protein 1 0.0506 0.0554 0.0763
Schistosoma mansoni tyrosine kinase 0.0081 0.0037 0.0036
Onchocerca volvulus 0.0095 0.0053 0.0492
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Echinococcus granulosus glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.0082 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis heat shock protein 0.0237 0.0227 0.0226
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0356 0.0372 0.0371
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Brugia malayi Protein kinase domain containing protein 0.0347 0.0361 0.0496
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.0071 0.0096
Onchocerca volvulus 0.0356 0.0372 0.3497
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0506 0.0554 0.0763
Mycobacterium ulcerans heat shock protein 90 0.0204 0.0186 0.0593
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Onchocerca volvulus 0.0506 0.0554 0.5212
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0073 0.0028 0.0026
Trypanosoma cruzi polyprenyl synthase, putative 0.0127 0.0093 0.3572
Plasmodium vivax endoplasmin, putative 0.0237 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Loa Loa (eye worm) voltage-gated potassium channel 0.0076 0.0031 0.0043
Loa Loa (eye worm) PAN domain-containing protein 0.0053 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Brugia malayi G protein-coupled receptor 0.0506 0.0554 0.0763
Onchocerca volvulus 0.0506 0.0554 0.5212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Treponema pallidum heat shock protein 90 0.0204 0.0186 1
Brugia malayi prolyl oligopeptidase family protein 0.0191 0.0171 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni tyrosine kinase 0.0081 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0109 0.0071 0.2503
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0506 0.0554 0.0763
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.6006 0.7245 1
Schistosoma mansoni voltage-gated cation channel 0.0076 0.0031 0.003
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.0422
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Brugia malayi olfactory channel protein osm-9 0.0076 0.0031 0.0041
Toxoplasma gondii PAN domain-containing protein 0.0601 0.0669 1
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2388 0.2843 1
Schistosoma mansoni adenosine deaminase-related 0.0084 0.004 0.0039
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0506 0.0554 0.0764
Echinococcus granulosus peptide allatostatin:somatostatin 0.0506 0.0554 0.0552
Schistosoma mansoni adenosine deaminase 0.0084 0.004 0.0039
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0506 0.0554 0.0763
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) LGC-31 protein 0.0205 0.0188 0.0259
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0095 0.0053 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0031 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.3667 0.4399 0.4399
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus granulosus potassium voltage gated channel subfamily A 0.1148 0.1334 0.1333
Echinococcus granulosus endoplasmin 0.0204 0.0186 0.0185
Echinococcus multilocularis glycine receptor subunit beta 0.0205 0.0188 0.0187
Echinococcus multilocularis adenosine deaminase 0.0084 0.004 0.0039
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0205 0.0188 0.0187
Echinococcus granulosus tm gpcr rhodopsin 0.0506 0.0554 0.0552
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0095 0.0053 0.0072
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Trichomonas vaginalis cyclins, putative 0.0087 0.0044 0.1331
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0076 0.0031 0.0041
Schistosoma mansoni neuropeptide F-like receptor 0.0506 0.0554 0.0552
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0001 0.0000072812
Brugia malayi Cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0106 0.0067 0.0092
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0076 0.0031 0.003
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.0422
Echinococcus granulosus transient receptor potential gamma protein 0.0076 0.0031 0.003
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Brugia malayi prolyl oligopeptidase family protein 0.0073 0.0028 0.0036
Trypanosoma cruzi CYC2-like cyclin, putative 0.0087 0.0044 0.121
Schistosoma mansoni hypothetical protein 0.0506 0.0554 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Brugia malayi G-protein coupled receptor 0.0506 0.0554 0.0763
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Brugia malayi Tachykinin-like peptides receptor 99D 0.0506 0.0554 0.0763
Echinococcus multilocularis ryanodine receptor 44f 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0111 0.0073 0.0071
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0127 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Brugia malayi cation channel family protein 0.0076 0.0031 0.0041
Onchocerca volvulus 0.0205 0.0188 0.1761
Trypanosoma cruzi heat shock protein 85, putative 0.0204 0.0186 0.8059
Trypanosoma brucei heat shock protein 84, putative 0.0067 0.0019 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0506 0.0554 0.0552
Brugia malayi Angiotensin-converting enzyme family protein 0.033 0.034 0.0467
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0204 0.0186 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.8271 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Entamoeba histolytica heat shock protein 90, putative 0.0237 0.0227 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Echinococcus granulosus neuropeptide Y receptor 0.0506 0.0554 0.0552
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0506 0.0554 0.5212
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0146 0.0115 0.1575
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Echinococcus granulosus heat shock protein 90 0.0237 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0069 0.0022 0.003
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0001 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0001 0.0002
Echinococcus granulosus GPCR family 2 0.1083 0.1255 0.1254
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Echinococcus granulosus g protein coupled receptor 0.0506 0.0554 0.0552
Schistosoma mansoni acetylcholine receptor-related 0.0095 0.0053 0.0052
Leishmania major polyprenyl synthase, putative 0.0127 0.0093 0.1211
Schistosoma mansoni biogenic amine receptor 0.0506 0.0554 0.0552
Chlamydia trachomatis glutamine binding protein 0.0082 0.0037 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis glycine receptor subunit beta 0.0205 0.0188 0.0187
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Brugia malayi Latrophilin receptor protein 2 0.1083 0.1255 0.1731
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0031 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Brugia malayi G protein-coupled receptor F59B2.13 0.0506 0.0554 0.0763
Schistosoma mansoni adenoreceptor 0.0506 0.0554 0.0552
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.0053 0.0052
Echinococcus granulosus glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis integrin alpha 3 0.0115 0.0079 0.0077
Echinococcus granulosus calcium activated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) glutaminase 0.0266 0.0262 0.0362
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) transcriptional regulator 0.0109 0.0071 0.0098
Echinococcus multilocularis tissue type plasminogen activator 0.0069 0.0022 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Onchocerca volvulus 0.0506 0.0554 0.5212
Onchocerca volvulus 0.0106 0.0067 0.0617
Schistosoma mansoni neuropeptide receptor 0.0506 0.0554 0.0552
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0071 0.2397
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0031 0.0041
Schistosoma mansoni neuropeptide f receptor 76f 0.0506 0.0554 0.0552
Schistosoma mansoni hypothetical protein 0.1083 0.1255 0.1254
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Schistosoma mansoni 60S ribosomal protein L21 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0125 0.009 0.0089
Brugia malayi hypothetical protein 0.0076 0.0031 0.0041
Echinococcus multilocularis integrin alpha ps 0.0068 0.002 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0001 0.0000072812
Echinococcus multilocularis fmrfamide receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0356 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.0347 0.0361 0.0498
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0127 0.0093 0.0129
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0506 0.0554 0.0552
Schistosoma mansoni neuropeptide receptor 0.8271 1 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis heat shock protein 90 0.0237 0.0227 0.0226
Schistosoma mansoni histamine h1 receptor 0.0506 0.0554 0.0552
Onchocerca volvulus 0.0506 0.0554 0.5212
Loa Loa (eye worm) hypothetical protein 0.0087 0.0044 0.0061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0506 0.0554 0.0552
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0356 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0037 0.0065
Onchocerca volvulus 0.0506 0.0554 0.5212
Plasmodium falciparum adenosine deaminase 0.0084 0.004 0.1003
Brugia malayi putative neuropeptide receptor NPR1 0.0506 0.0554 0.0763
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0031 0.003
Echinococcus multilocularis neuropeptide receptor 0.8271 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0084 0.004 0.0075
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus multilocularis epidermal growth factor receptor 0.0154 0.0126 0.0124
Trypanosoma cruzi prolyl endopeptidase 0.0146 0.0115 0.4643
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0111 0.0073 0.0071
Entamoeba histolytica heat shock protein 90, putative 0.0237 0.0227 1
Brugia malayi hypothetical protein 0.0095 0.0053 0.0072
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0251 0.0346
Brugia malayi neuropeptide F receptor 0.0506 0.0554 0.0763
Echinococcus granulosus ryanodine receptor 44f 0.0076 0.0031 0.003
Echinococcus granulosus Dipeptidyl peptidase 9 0.0073 0.0028 0.0026
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Loa Loa (eye worm) hypothetical protein 0.2339 0.2784 0.3842
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0125 0.009 0.0089
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0053 0.0072
Onchocerca volvulus 0.0923 0.1061 1
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Trypanosoma cruzi heat shock protein 85, putative 0.0237 0.0227 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0076 0.0031 0.003
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0076 0.0031 0.003
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0404 0.043 0.0593
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.003
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0076 0.0031 0.003
Loa Loa (eye worm) integrin alpha pat-2 0.0232 0.0221 0.0304
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.003
Trichomonas vaginalis cyclins, putative 0.0087 0.0044 0.1331
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0121 0.0166
Loa Loa (eye worm) heat shock protein 90 0.0237 0.0227 0.0313
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0095 0.0053 0.0074
Plasmodium falciparum heat shock protein 90 0.0237 0.0227 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0076 0.0031 0.003
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.004 0.0562
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0083 0.0039 0.0054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0031 0.0801
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Echinococcus granulosus potassium voltage gated channel protein 0.0125 0.009 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0076 0.0031 0.0569
Treponema pallidum octaprenyl-diphosphate synthase 0.0127 0.0093 0.3746
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0205 0.0188 0.0258
Brugia malayi hypothetical protein 0.0432 0.0464 0.0638
Brugia malayi RE15519p 0.0506 0.0554 0.0763
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0007 0.0071
Schistosoma mansoni calcium-activated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni voltage-dependent calcium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus granulosus potassium voltage gated channel protein 0.1148 0.1334 0.1333
Schistosoma mansoni biogenic amine receptor 0.0506 0.0554 0.0552
Toxoplasma gondii kringle domain-containing protein 0.0094 0.0052 0.0744
Schistosoma mansoni lozenge 0.0054 0.0004 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.0154 0.0126 0.0124
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0127 0.0093 0.0127
Loa Loa (eye worm) runx1 0.0054 0.0004 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.3667 0.4399 0.4399
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Brugia malayi Transient-receptor-potential like protein 0.0076 0.0031 0.0041
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Schistosoma mansoni heat shock protein 0.0237 0.0227 0.0226
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0076 0.0031 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.0031 0.003
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0125 0.009 0.0089
Schistosoma mansoni heat shock protein 0.0067 0.0019 0.0018
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0031 0.003
Treponema pallidum adenosine deaminase 0.0084 0.004 0.0188
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Onchocerca volvulus 0.0506 0.0554 0.5212
Loa Loa (eye worm) acetylcholine receptor protein 0.0095 0.0053 0.0074
Onchocerca volvulus 0.0087 0.0044 0.0405
Echinococcus granulosus glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Onchocerca volvulus 0.0506 0.0554 0.5212
Echinococcus multilocularis potassium large conductance calcium activated 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) ACC-1 protein 0.0205 0.0188 0.0259
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0095 0.0053 0.0072
Echinococcus multilocularis neuropeptide receptor 0.0506 0.0554 0.0552
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0095 0.0053 0.0074
Brugia malayi AKH receptor 0.0506 0.0554 0.0763
Schistosoma mansoni tyrosine kinase 0.0083 0.004 0.0038
Brugia malayi Cyclin, N-terminal domain containing protein 0.0087 0.0044 0.0059
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0031 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0506 0.0554 0.0552
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.008 0.0078
Echinococcus multilocularis potassium voltage gated channel protein 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus granulosus potassium voltage gated channel protein 0.0125 0.009 0.0089
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0506 0.0554 0.0552
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0053 0.0072
Echinococcus granulosus sodium channel protein 0.057 0.0632 0.063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0506 0.0554 0.0552
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.003
Toxoplasma gondii heat shock protein 75, putative 0.0067 0.0019 0.025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Onchocerca volvulus 0.0506 0.0554 0.5212
Brugia malayi larval opioid receptor 0.0506 0.0554 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0154 0.5711
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0205 0.0188 0.0187
Echinococcus multilocularis neuropeptide Y receptor 0.0506 0.0554 0.0552
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0053 0.0072
Loa Loa (eye worm) endoplasmin 0.0237 0.0227 0.0313
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0109 0.0071 0.007
Brugia malayi Peroxidasin 0.0052 0.0001 0.0000072812
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Trypanosoma cruzi cyclin, putative 0.0087 0.0044 0.121
Onchocerca volvulus Adenosine deaminase homolog 0.0084 0.004 0.0367
Brugia malayi solute carrier family 40, member 1 0.0404 0.043 0.0591
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Onchocerca volvulus 0.0356 0.0372 0.3497
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Brugia malayi Blistered cuticle protein 3 0.0052 0.0001 0.0000072812
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0076 0.0031 0.003
Echinococcus granulosus shaker cognate 0.0125 0.009 0.0089
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Loa Loa (eye worm) TK/EGFR protein kinase 0.0154 0.0126 0.0173
Echinococcus multilocularis g protein coupled receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.0031 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0506 0.0554 0.0552
Echinococcus granulosus cyclin B 0.0087 0.0044 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0057 0.0007 0.001
Trichomonas vaginalis endoplasmin, putative 0.01 0.006 0.1948
Echinococcus granulosus sex peptide receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) PAN domain-containing protein 0.0053 0.0003 0.0004
Onchocerca volvulus 0.0076 0.0031 0.0279
Echinococcus granulosus adenosine deaminase 0.0084 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0205 0.0188 0.0187
Echinococcus granulosus TRP transient receptor potential channel 0.0076 0.0031 0.003
Loa Loa (eye worm) TK/EPH protein kinase 0.0137 0.0104 0.0144
Brugia malayi GnHR receptor homolog 0.2295 0.273 0.3767
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2388 0.2843 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus granulosus tm gpcr rhodopsin 0.0506 0.0554 0.0552
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0031 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0506 0.0554 0.0552
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0109 0.0071 0.1691
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Brugia malayi putative neuropeptide receptor 0.0506 0.0554 0.0763
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Echinococcus multilocularis heat shock protein 90 0.0204 0.0186 0.0185
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0095 0.0053 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0076 0.0031 0.003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Schistosoma mansoni neurotransmitter gated ion channel 0.0111 0.0073 0.0071
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0073 0.0028 0.028
Plasmodium falciparum endoplasmin, putative 0.01 0.006 0.1945
Schistosoma mansoni hypothetical protein 0.2339 0.2784 0.2783
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.004 0.1003
Loa Loa (eye worm) PAN domain-containing protein 0.0053 0.0003 0.0004
Echinococcus granulosus somatostatin receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0031 0.003
Trichomonas vaginalis heat shock protein, putative 0.0237 0.0227 0.8583
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0125 0.009 0.0089
Echinococcus multilocularis neuropeptide s receptor 0.0958 0.1104 0.1103
Brugia malayi hypothetical protein 0.0052 0.0001 0.0000072812
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0073 0.0028 0.0026
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0432 0.0464 0.064
Brugia malayi Cyclin, N-terminal domain containing protein 0.0087 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Trypanosoma brucei Heat shock protein 83, putative 0.0237 0.0227 0.6754
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0191 0.0171 0.017
Trichomonas vaginalis glutaminase, putative 0.0266 0.0262 1
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Brugia malayi Melatonin receptor type 1A 0.0506 0.0554 0.0763
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.0125 0.009 0.0124
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus multilocularis ephrin type A receptor 4 A 0.0133 0.01 0.0098
Brugia malayi ORL1-like opioid receptor 0.0506 0.0554 0.0763
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0022 0.0128
Brugia malayi heat shock protein 90 0.0237 0.0227 0.0311
Echinococcus multilocularis serotonin receptor 0.0506 0.0554 0.0552
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0076 0.0031 0.0041
Loa Loa (eye worm) ACC-1 protein 0.0205 0.0188 0.0259
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni hypothetical protein 0.0506 0.0554 0.0552
Echinococcus granulosus g protein coupled receptor 0.0506 0.0554 0.0552
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0037 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Giardia lamblia Heat shock protein HSP 90-alpha 0.0204 0.0186 0.7791
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0076 0.0031 0.0041
Toxoplasma gondii hypothetical protein 0.0076 0.0031 0.0422
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0356 0.0372 0.0513
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0043
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.008 0.0078
Loa Loa (eye worm) ryanodine receptor 0.0076 0.0031 0.0043
Echinococcus granulosus neuropeptide s receptor 0.0958 0.1104 0.1103
Echinococcus granulosus alpha 1A adrenergic receptor 0.0506 0.0554 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Giardia lamblia Grp94/Hsp90 0.0204 0.0186 0.7791
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.1083 0.1255 0.1254
Onchocerca volvulus 0.0404 0.043 0.4041
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0067 0.0019 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0268 0.0264 0.0263
Schistosoma mansoni endoplasmin 0.0237 0.0227 0.0226
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0076 0.0031 0.0041
Trichomonas vaginalis cyclin B, putative 0.0087 0.0044 0.1331
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Schistosoma mansoni neuropeptide receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Onchocerca volvulus 0.0053 0.0003 0.0013
Echinococcus granulosus glutamate NMDA receptor subunit 0.0268 0.0264 0.0263
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0076 0.0031 0.0279
Schistosoma mansoni voltage-gated potassium channel 0.1148 0.1334 0.1333
Echinococcus multilocularis nAChR subunit 0.0205 0.0188 0.0187
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0031 0.0801
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.0115 0.0114
Trypanosoma brucei heat shock protein 90, putative 0.0237 0.0227 0.6754
Echinococcus granulosus integrin alpha ps 0.0068 0.002 0.0019
Echinococcus multilocularis sodium channel protein 0.057 0.0632 0.063
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0204 0.0186 0.0593
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0191 0.0171 0.017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0205 0.0188 0.0187
Echinococcus granulosus prolyl endopeptidase 0.0146 0.0115 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Loa Loa (eye worm) voltage-gated potassium channel 0.0125 0.009 0.0124
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0073 0.0028 0.0414
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0076 0.0031 0.003
Echinococcus granulosus biogenic amine 5HT receptor 0.0506 0.0554 0.0552
Schistosoma mansoni lipoxygenase 0.0081 0.0037 0.0036
Echinococcus granulosus G protein coupled receptor 139 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.003
Schistosoma mansoni nAChR subunit 0.0095 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Onchocerca volvulus 0.0111 0.0073 0.0674
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) voltage-gated calcium channel 0.0076 0.0031 0.0043
Echinococcus granulosus 7tm_1 domain containing protein 0.0506 0.0554 0.0552
Schistosoma mansoni two-pore calcium channel 0.0076 0.0031 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0237 0.0227 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0506 0.0554 0.0552
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0125 0.009 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0043
Trichomonas vaginalis cyclins, putative 0.0087 0.0044 0.1331
Leishmania major calcium channel protein, putative,ion transporter, putative 0.057 0.0632 1
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.004 0.1172
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.0076 0.0075
Onchocerca volvulus 0.0053 0.0003 0.0013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0506 0.0554 0.0552
Trypanosoma brucei heat shock protein 90, putative 0.0237 0.0227 0.6754
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Onchocerca volvulus 0.0069 0.0022 0.0193
Schistosoma mansoni tyrosine kinase 0.0154 0.0126 0.0124
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0143 0.1341
Echinococcus granulosus neuropeptide Y receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Leishmania major cyclin 0.0087 0.0044 0.0411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.5283 0.6365 0.8786
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0506 0.0554 0.0763
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0205 0.0188 0.0258
Giardia lamblia Heat shock protein HSP 90-alpha 0.0237 0.0227 1
Echinococcus granulosus heat shock protein 90 0.0204 0.0186 0.0185
Entamoeba histolytica cyclin, putative 0.0087 0.0044 0.1196
Schistosoma mansoni tyrosine kinase 0.0083 0.004 0.0038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0506 0.0554 0.0552
Schistosoma mansoni serine-type protease inhibitor 0.6088 0.7345 0.7344
Schistosoma mansoni integrin alpha 0.0151 0.0121 0.012
Brugia malayi Endoplasmin precursor 0.0237 0.0227 0.0311
Onchocerca volvulus 0.0111 0.0073 0.0674
Trichomonas vaginalis cyclin B, putative 0.0087 0.0044 0.1331
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0054 0.0004 0.0003
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0001 0.0000072812
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0191 0.0171 0.1602
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0111 0.0073 0.0099
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Brugia malayi Furin-like cysteine rich region family protein 0.0154 0.0126 0.0172
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.0071 0.2491
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Echinococcus multilocularis cyclin B 0.0087 0.0044 0.0043
Onchocerca volvulus 0.0506 0.0554 0.5212
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0087 0.0044 0.0411
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0073 0.0028 0.0374
Toxoplasma gondii PAN domain-containing protein 0.0601 0.0669 1
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.004 0.0038
Schistosoma mansoni hypothetical protein 0.1083 0.1255 0.1254
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Brugia malayi Adenosine/AMP deaminase family protein 0.0084 0.004 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.0506 0.0554 0.0552
Schistosoma mansoni heat shock protein 0.0237 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0205 0.0188 0.0187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0031 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0506 0.0554 0.0552
Trichomonas vaginalis heat shock protein, putative 0.0204 0.0186 0.6982
Brugia malayi hypothetical protein 0.0095 0.0053 0.0072
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0031 0.003
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.004 0.1003
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Echinococcus granulosus potassium voltage gated channel protein 0.0076 0.0031 0.003
Brugia malayi ion channel NompC 0.0076 0.0031 0.0041
Echinococcus multilocularis g protein coupled receptor 0.0506 0.0554 0.0552
Onchocerca volvulus 0.0205 0.0188 0.1761
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Brugia malayi Cation transporter family protein 0.0205 0.0188 0.0258
Schistosoma mansoni hypothetical protein 0.0319 0.0327 0.0325
Trichomonas vaginalis heat shock protein, putative 0.0204 0.0186 0.6982
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0506 0.0554 0.0552
Loa Loa (eye worm) latrophilin receptor protein 2 0.1083 0.1255 0.1733
Echinococcus granulosus neuropeptide receptor A26 0.0958 0.1104 0.1103
Echinococcus multilocularis somatostatin receptor 0.0506 0.0554 0.0552
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0506 0.0554 0.0552
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.003
Loa Loa (eye worm) TYRA-2 protein 0.0506 0.0554 0.0764
Schistosoma mansoni hypothetical protein 0.0506 0.0554 0.0552
Leishmania major heat shock protein, putative 0.0067 0.0019 0.0006
Schistosoma mansoni tyrosine kinase 0.0081 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.0114 0.0077 0.0106
Loa Loa (eye worm) hypothetical protein 0.0356 0.0372 0.0513
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0001 0.0002
Loa Loa (eye worm) calcium channel 0.0076 0.0031 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0356 0.0372 0.0371
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.1083 0.1255 0.1731
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.0076 0.0075
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0109 0.0071 0.2503
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0076 0.0031 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0205 0.0188 0.0258
Echinococcus granulosus heat shock protein 0.0237 0.0227 0.0226
Plasmodium vivax adenosine deaminase, putative 0.0084 0.004 0.1003
Schistosoma mansoni hypothetical protein 0.0076 0.0031 0.003
Echinococcus multilocularis calcium activated potassium channel 0.0076 0.0031 0.003
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0076 0.0031 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0205 0.0188 0.0259
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0073 0.0028 0.028
Onchocerca volvulus 0.0506 0.0554 0.5212
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0205 0.0188 0.0187
Schistosoma mansoni biogenic amine receptor 0.0506 0.0554 0.0552
Brugia malayi Serotonin receptor 0.0506 0.0554 0.0763
Brugia malayi cation channel family protein 0.0076 0.0031 0.0041
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0356 0.0372 0.0371
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0251 0.0345
Loa Loa (eye worm) PAN domain-containing protein 0.0053 0.0003 0.0004
Onchocerca volvulus 0.0432 0.0464 0.4362
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.1083 0.1255 0.1254
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0076 0.0031 0.0384
Schistosoma mansoni opsin-like receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis potassium voltage gated channel protein 0.0125 0.009 0.0089
Schistosoma mansoni biogenic amine (5HT) receptor 0.0506 0.0554 0.0552
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.0053 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0268 0.0264 0.0263
Brugia malayi Dopamine receptor protein 2 0.0506 0.0554 0.0763
Echinococcus multilocularis neuropeptide Y receptor 0.0506 0.0554 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Loa Loa (eye worm) hypothetical protein 0.1083 0.1255 0.1733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.1083 0.1255 0.1254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni myosin xvIII 0.0506 0.0554 0.0552
Loa Loa (eye worm) neuropeptide F receptor 0.0506 0.0554 0.0764
Brugia malayi neuropeptide F receptor 0.0506 0.0554 0.0763
Echinococcus granulosus hypothetical protein 0.0506 0.0554 0.0552
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.004 0.0562
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0205 0.0188 0.0259
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0073 0.0028 0.0141
Trypanosoma cruzi cyclin, putative 0.0087 0.0044 0.121
Trypanosoma cruzi heat shock protein, putative 0.0067 0.0019 0.0017
Echinococcus granulosus nAChR subunit 0.0205 0.0188 0.0187
Echinococcus granulosus dro:myosuppressin receptor 0.0506 0.0554 0.0552
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis sodium leak channel non selective protein 0.0076 0.0031 0.003
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0076 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Onchocerca volvulus 0.0053 0.0003 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0506 0.0554 0.0764
Echinococcus multilocularis endoplasmin 0.0204 0.0186 0.0185
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0356 0.0372 0.0371
Onchocerca volvulus 0.0053 0.0003 0.0013
Leishmania major hypothetical protein, conserved 0.0069 0.0022 0.0044
Onchocerca volvulus 0.0506 0.0554 0.5212
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Leishmania major hypothetical protein, unknown function 0.0076 0.0031 0.0193
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0191 0.0171 0.017
Trypanosoma cruzi cyclin 6, putative 0.0087 0.0044 0.121
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.0115 0.0158
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0205 0.0188 0.0187
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0076 0.0031 0.003
Echinococcus granulosus neuropeptide receptor 0.0506 0.0554 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0143 0.5272
Schistosoma mansoni hypothetical protein 0.0428 0.0458 0.0457
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0084 0.004 0.0075
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0205 0.0188 0.0187
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0031 0.003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0506 0.0554 0.0552
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0016 0.0014
Onchocerca volvulus 0.0506 0.0554 0.5212
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.004 0.1172
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0111 0.0073 0.0099
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Trypanosoma brucei heat shock protein, putative 0.0237 0.0227 0.6754
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0205 0.0188 0.0258
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0057 0.0007 0.001
Loa Loa (eye worm) melatonin receptor type 1A 0.0506 0.0554 0.0764
Schistosoma mansoni voltage-gated potassium channel 0.1148 0.1334 0.1333
Echinococcus granulosus ephrin type A receptor 4 A 0.0133 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0084 0.004 0.0055
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0001 0.0000072812
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0204 0.0186 0.0185
Trichomonas vaginalis cyclin A, putative 0.0087 0.0044 0.1331
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Schistosoma mansoni amine GPCR 0.0506 0.0554 0.0552
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.1148 0.1334 0.1841
Trypanosoma brucei mitotic cyclin 6 0.0087 0.0044 0.0818
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0071 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.009 0.0089
Echinococcus multilocularis neuropeptides capa receptor 0.0506 0.0554 0.0552
Toxoplasma gondii hypothetical protein 0.0076 0.0031 0.0422
Brugia malayi voltage-dependent calcium channel 0.0076 0.0031 0.0041
Trypanosoma cruzi heat shock protein 90, putative 0.0237 0.0227 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0031 0.003
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0204 0.0186 0.2733
Echinococcus granulosus two pore calcium channel protein 1 0.0076 0.0031 0.003
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0205 0.0188 0.0259
Schistosoma mansoni alpha-1 adrenergic receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0205 0.0188 0.0259
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) ion channel NompC 0.0076 0.0031 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Echinococcus multilocularis shaker cognate 0.0125 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) PAN domain-containing protein 0.0053 0.0003 0.0004
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0076 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.0069 0.0022 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0205 0.0188 0.0259
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.0458 0.0457
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0076 0.0031 0.0569
Echinococcus multilocularis fmrfamide receptor 0.0506 0.0554 0.0552
Echinococcus granulosus voltage gated hydrogen channel 1 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Leishmania major hypothetical protein, conserved 0.0076 0.0031 0.0193
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0076 0.0031 0.003
Echinococcus granulosus tissue type plasminogen activator 0.0069 0.0022 0.002
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.0031 0.003
Loa Loa (eye worm) TK/ROR protein kinase 0.0071 0.0024 0.0033
Brugia malayi excitatory GABA receptor EXP-1A 0.0205 0.0188 0.0258
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0125 0.009 0.0123
Onchocerca volvulus 0.0095 0.0053 0.0492
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus granulosus neuropeptides capa receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Trypanosoma cruzi heat shock protein 90, putative 0.0204 0.0186 0.8059
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.003
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.003
Echinococcus multilocularis g protein coupled receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis sex peptide receptor 0.0506 0.0554 0.0552
Echinococcus granulosus fmrfamide receptor 0.0506 0.0554 0.0552
Trypanosoma brucei RNA helicase, putative 0.0319 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.1148 0.1334 0.1842
Trichomonas vaginalis heat shock protein, putative 0.0204 0.0186 0.6982
Loa Loa (eye worm) glutaminase 2 0.0266 0.0262 0.0362
Plasmodium vivax heat shock protein 86, putative 0.0237 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0076 0.0031 0.0384
Echinococcus granulosus integrin alpha 3 0.0115 0.0079 0.0077
Loa Loa (eye worm) hypothetical protein 0.0432 0.0464 0.064
Echinococcus multilocularis GPCR, family 2 0.1083 0.1255 0.1254
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Onchocerca volvulus 0.0356 0.0372 0.3497
Onchocerca volvulus 0.0053 0.0003 0.0013
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2388 0.2843 1
Brugia malayi Cation transporter family protein 0.0205 0.0188 0.0258
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0095 0.0053 0.0074
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0125 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Onchocerca volvulus 0.0506 0.0554 0.5212
Schistosoma mansoni hypothetical protein 0.0506 0.0554 0.0552
Schistosoma mansoni nAChR subunit 0.0095 0.0053 0.0052
Brugia malayi Kringle domain containing protein 0.0069 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0923 0.1061 0.1464
Echinococcus granulosus sodium leak channel non selective protein 0.0076 0.0031 0.003
Onchocerca volvulus 0.0053 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0506 0.0554 0.0552
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0031 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0506 0.0554 0.0552
Echinococcus multilocularis voltage gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Schistosoma mansoni growth hormone secretagogue receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0003 0.0004
Brugia malayi hypothetical protein 0.0506 0.0554 0.0763
Echinococcus granulosus allatostatin A receptor 0.0923 0.1061 0.106
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.003
Echinococcus granulosus g-protein coupled receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis integrin alpha ps 0.0068 0.002 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Brugia malayi Cation transporter family protein 0.0356 0.0372 0.0512
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0205 0.0188 0.0258
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0076 0.0031 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0154 0.5711
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0356 0.0372 0.0371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0076 0.0031 0.0422
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Brugia malayi hypothetical protein 0.0095 0.0053 0.0072
Schistosoma mansoni amine GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.0115 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.5283 0.6365 0.8786
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0251 0.9543
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0506 0.0554 0.0552
Echinococcus granulosus g protein coupled receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.033 0.034 0.0469
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0111 0.0073 0.0099
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Schistosoma mansoni integrin alpha-ps 0.0068 0.002 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0506 0.0554 0.0552
Onchocerca volvulus 0.0053 0.0003 0.0013
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Schistosoma mansoni amine GPCR 0.0506 0.0554 0.0552
Echinococcus multilocularis chromatin regulatory protein sir2 0.0109 0.0071 0.007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.003
Onchocerca volvulus Putative nachr subunit 0.0356 0.0372 0.3497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0073 0.0028 0.0414
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0125 0.009 0.0089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0076 0.0031 0.0422
Toxoplasma gondii heat shock protein HSP90 0.0237 0.0227 0.3362
Trichomonas vaginalis heat shock protein, putative 0.0067 0.0019 0.0346
Brugia malayi Hsp90 protein 0.0067 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0532 0.0585 0.0808
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0205 0.0188 0.0187
Echinococcus multilocularis two pore calcium channel protein 1 0.0076 0.0031 0.003
Toxoplasma gondii prolyl endopeptidase 0.0146 0.0115 0.1692
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0076 0.0031 0.003
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0205 0.0188 0.0187
Trypanosoma cruzi heat shock protein 90, putative 0.017 0.0146 0.6094
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0076 0.0031 0.003
Onchocerca volvulus 0.0053 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0095 0.0053 0.0052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0205 0.0188 0.0258
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis prolyl endopeptidase 0.0146 0.0115 0.0114
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0031 0.003
Schistosoma mansoni vesicular amine transporter 0.0125 0.009 0.0089
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.057 0.0632 0.063
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0095 0.0053 0.0052
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0506 0.0554 0.0552
Brugia malayi hypothetical protein 0.0095 0.0053 0.0072
Schistosoma mansoni amine GPCR 0.0506 0.0554 0.0552
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0127 0.0093 0.0092
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0076 0.0031 0.003
Onchocerca volvulus 0.0053 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis potassium voltage gated channel protein 0.1148 0.1334 0.1333
Schistosoma mansoni nAChR subunit 0.0205 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0111 0.0073 0.01
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.0031 0.003
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0076 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.1083 0.1255 0.1254
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0071 0.2397
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.003
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0031 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0205 0.0188 0.0259
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0262 0.0257 0.0354
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0077 0.0104
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0204 0.0186 0.0593
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Schistosoma mansoni neuropeptide receptor 0.0506 0.0554 0.0552
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.003
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0067 0.0019 0.0171
Echinococcus multilocularis serotonin receptor 0.0506 0.0554 0.0552
Brugia malayi G-protein coupled receptor 0.0506 0.0554 0.0763
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Trichomonas vaginalis cyclin B, putative 0.0087 0.0044 0.1331
Echinococcus granulosus dnaJ subfamily B 0.0428 0.0458 0.0457
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0125 0.009 0.0123
Echinococcus granulosus two pore calcium channel protein 2 0.0076 0.0031 0.003
Schistosoma mansoni endoplasmin 0.0237 0.0227 0.0226
Loa Loa (eye worm) neuropeptide F receptor 0.0506 0.0554 0.0764
Schistosoma mansoni serine-type protease inhibitor 0.6088 0.7345 0.7344
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus multilocularis neuropeptide receptor A26 0.0958 0.1104 0.1103
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0071 0.007
Loa Loa (eye worm) prolyl oligopeptidase 0.0191 0.0171 0.0236
Onchocerca volvulus Neuropeptide F receptor homolog 0.0506 0.0554 0.5212
Brugia malayi hypothetical protein 0.0095 0.0053 0.0072
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0082 0.0037 0.5
Schistosoma mansoni cyclin B 0.0087 0.0044 0.0043
Leishmania major adenine aminohydrolase 0.0084 0.004 0.0345
Brugia malayi Caveolin-1 0.0532 0.0585 0.0806
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Echinococcus multilocularis transfer RNA-Gly 0.0125 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0146 0.0115 0.0159
Onchocerca volvulus 0.0506 0.0554 0.5212
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0127 0.0093 0.0092
Echinococcus multilocularis neuropeptide FF receptor 2 0.0506 0.0554 0.0552
Onchocerca volvulus 0.0053 0.0003 0.0013
Loa Loa (eye worm) GABA receptor subunit 0.0111 0.0073 0.01
Echinococcus granulosus voltage gated potassium channel 0.0125 0.009 0.0089
Onchocerca volvulus 0.0095 0.0053 0.0492
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0043
Echinococcus multilocularis Protein lozenge 0.0054 0.0004 0.0003
Echinococcus granulosus voltage gated potassium channel 0.0076 0.0031 0.003
Schistosoma mansoni glutaminase 0.0266 0.0262 0.0261
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0506 0.0554 0.0552
Echinococcus granulosus hypothetical protein 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Onchocerca volvulus 0.0506 0.0554 0.5212
Trichomonas vaginalis cyclins, putative 0.0087 0.0044 0.1331
Trichomonas vaginalis heat shock protein, putative 0.01 0.006 0.1948
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0356 0.0372 0.0371
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Echinococcus multilocularis transient receptor potential gamma protein 0.0076 0.0031 0.003
Onchocerca volvulus 0.0053 0.0003 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni biogenic amine (5HT) receptor 0.0506 0.0554 0.0552
Echinococcus granulosus glycine receptor subunit beta 0.0205 0.0188 0.0187
Echinococcus multilocularis nAChR subunit 0.0111 0.0073 0.0071
Schistosoma mansoni acetylcholine receptor subunit beta 0.0095 0.0053 0.0052
Loa Loa (eye worm) voltage-dependent calcium channel 0.0076 0.0031 0.0043
Brugia malayi PAN domain containing protein 0.0053 0.0003 0.0002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0076 0.0031 0.003
Echinococcus multilocularis potassium voltage gated channel protein 0.0125 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0356 0.0372 0.0513
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.0422
Leishmania major heat shock protein 83-1 0.0237 0.0227 0.3392
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Toxoplasma gondii heat shock protein 90, putative 0.0237 0.0227 0.3362
Onchocerca volvulus Prolyl endopeptidase homolog 0.0146 0.0115 0.1078
Echinococcus multilocularis g-protein coupled receptor 0.0506 0.0554 0.0552
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0118 0.0082 0.0113
Mycobacterium ulcerans adenosine deaminase 0.0084 0.004 0.0075
Schistosoma mansoni lipoxygenase 0.0116 0.008 0.0078
Loa Loa (eye worm) hypothetical protein 0.0356 0.0372 0.0513
Loa Loa (eye worm) hypothetical protein 0.0052 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0111 0.0073 0.2572
Echinococcus granulosus serotonin receptor 0.0506 0.0554 0.0552
Loa Loa (eye worm) hypothetical protein 0.0087 0.0044 0.0061
Trichomonas vaginalis cyclin B, putative 0.0087 0.0044 0.1331
Loa Loa (eye worm) hypothetical protein 0.0506 0.0554 0.0764
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0031 0.003
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0076 0.0031 0.0041
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0076 0.0031 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0506 0.0554 0.0552
Schistosoma mansoni transient receptor potential channel 4 0.0076 0.0031 0.003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0205 0.0188 0.0258
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0506 0.0554 0.0552
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0076 0.0031 0.003
Brugia malayi follicle stimulating hormone receptor 0.073 0.0826 0.1139
Loa Loa (eye worm) G-protein coupled receptor 0.0506 0.0554 0.0764
Echinococcus granulosus nAChR subunit 0.0111 0.0073 0.0071

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.6 Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (binding) = 0.28 uM Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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