Detailed information for compound 995625

Basic information

Technical information
  • TDR Targets ID: 995625
  • Name: [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihy droxyoxolan-2-yl]methyl-(hydroxy-phosphonooxy phosphoryl)oxyphosphinic acid
  • MW: 491.182 | Formula: C10H16N5O12P3
  • H donors: 7 H acceptors: 12 LogP: -5.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: O[C@@H]1[C@H](O[C@H]([C@@H]1O)n1cnc2c1ncnc2N)CP(=O)(OP(=O)(OP(=O)(O)O)O)O
  • InChi: 1S/C10H16N5O12P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-28(18,19)26-30(23,24)27-29(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,23,24)(H2,11,12,13)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1
  • InChiKey: LOKYZGJFPHNJPB-KQYNXXCUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid
  • [(2S,3S,4R,5R)-5-(6-amino-9-purinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl-(hydroxy-phosphonooxyphosphoryl)oxyphosphinic acid
  • [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0141 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0531 0.0531
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0346 0.0346
Brugia malayi Carboxylesterase family protein 0.0132 0.3387 0.9088
Echinococcus multilocularis ribonuclease H1 0.0018 0.0214 0.0214
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0346 0.0346
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0012 0.004 0.004
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0688 1
Loa Loa (eye worm) carboxylesterase 0.0036 0.0731 0.1961
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0051 0.0051
Echinococcus multilocularis neuropeptide receptor A26 0.0302 0.8073 0.8073
Echinococcus granulosus acetylcholinesterase 0.0132 0.3387 0.3387
Echinococcus granulosus ribonuclease H1 0.0018 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0092
Schistosoma mansoni ap endonuclease 0.0012 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0346 0.0929
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0346 0.0929
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0776 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0141 0.0244
Brugia malayi nuclear receptor RXR 0.0011 0.0016 0.0042
Schistosoma mansoni acetylcholinesterase 0.0036 0.0731 0.0731
Onchocerca volvulus 0.0023 0.0346 0.4621
Treponema pallidum ribonuclease H (rnhA) 0.0018 0.0214 0.7568
Schistosoma mansoni gliotactin 0.0036 0.0731 0.0731
Echinococcus multilocularis tumor protein p63 0.0193 0.5075 0.5075
Echinococcus granulosus BC026374 protein S09 family 0.0036 0.0731 0.0731
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0346 0.0929
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0137
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3387 0.3387
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0776 1
Schistosoma mansoni intermediate filament proteins 0.0017 0.0198 0.0198
Brugia malayi RNase H family protein 0.0018 0.0214 0.0574
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0046 0.0987 0.2649
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0346 0.0929
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0016 0.0042
Brugia malayi hypothetical protein 0.0012 0.0051 0.0137
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.013 0.3311 0.3311
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0346 0.0346
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0016 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0776 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0063 0.0433
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0141 0.0377
Brugia malayi Carboxylesterase family protein 0.0036 0.0731 0.1961
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.004 0.004
Onchocerca volvulus 0.0036 0.0731 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0046 0.0987 0.0987
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0063 0.0063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0603 0.1619
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0016 0.0016
Brugia malayi Carboxylesterase family protein 0.0036 0.0731 0.1961
Mycobacterium ulcerans hypothetical protein 0.0015 0.0141 0.0244
Echinococcus granulosus neuropeptide s receptor 0.0302 0.8073 0.8073
Giardia lamblia Ribonuclease H 0.0018 0.0214 0.1374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0346 0.0929
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0052 0.1163 0.1163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0141 0.0282
Onchocerca volvulus 0.0017 0.0198 0.2553
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0052 0.1163 0.1163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0603 0.1619
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0531 0.0531
Brugia malayi Carboxylesterase family protein 0.0036 0.0731 0.1961
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0346 0.0929
Entamoeba histolytica acyl-coA synthetase, putative 0.0015 0.0141 0.1243
Schistosoma mansoni phosphoglucomutase 0.0018 0.0214 0.0214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0346 0.0346
Echinococcus granulosus neuroligin 0.0036 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0141 0.1243
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0346 0.0346
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0051 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0346 0.0346
Onchocerca volvulus 0.0036 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0474 0.0474
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0688 0.5689
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0603 0.1619
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0137
Schistosoma mansoni ap endonuclease 0.0012 0.0063 0.0063
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Echinococcus granulosus lamin dm0 0.0017 0.0198 0.0198
Echinococcus granulosus acetylcholinesterase 0.0132 0.3387 0.3387
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0346 0.0929
Mycobacterium tuberculosis Carboxylesterase LipT 0.0168 0.4384 1
Loa Loa (eye worm) acetyltransferase 0.013 0.3311 0.8884
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Trypanosoma brucei ingi protein (ORF1) 0.0019 0.0256 0.128
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0346 0.0346
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0016 0.0016
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.002 0.0262 1
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0092
Brugia malayi RNase H family protein 0.0018 0.0214 0.0574
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0776 0.0776
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.002 0.0262 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0346 0.0929
Echinococcus multilocularis neuropeptide s receptor 0.0302 0.8073 0.8073
Trichomonas vaginalis spcc417.12 protein, putative 0.0036 0.0731 0.936
Echinococcus granulosus lamin 0.0017 0.0198 0.0198
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.002 0.0262 0.0524
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0346 0.4621
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0063 0.0382
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0346 0.4621
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0346 0.0346
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0603 0.1619
Schistosoma mansoni hypothetical protein 0.0371 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0346 0.0929
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0092
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0346 0.0346
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0346 0.0346
Onchocerca volvulus 0.0036 0.0731 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0141 0.5148
Onchocerca volvulus 0.0017 0.0198 0.2553
Loa Loa (eye worm) hypothetical protein 0.0028 0.0504 0.1354
Trypanosoma brucei RNA helicase, putative 0.0067 0.157 1
Brugia malayi steroid hormone receptor 0.0023 0.0346 0.0929
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0052 0.1163 0.1163
Brugia malayi nuclear receptor NHR-67 0.0011 0.0016 0.0042
Echinococcus granulosus glutamate receptor 2 0.0012 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Echinococcus multilocularis para nitrobenzyl esterase 0.0036 0.0731 0.0731
Onchocerca volvulus 0.0036 0.0731 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0346 0.0929
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0063 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0346 0.0929
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.013 0.3311 0.3311
Brugia malayi hypothetical protein 0.0011 0.0016 0.0042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0141 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0474 0.0474
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0731 0.0731
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0051 0.0137
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0012 0.0063 0.0104
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0198 0.0532
Brugia malayi hypothetical protein 0.0011 0.0016 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0141 0.0377
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3387 0.3387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0324 0.087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0346 0.0346
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0346 0.0346
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0346 0.4621
Schistosoma mansoni hypothetical protein 0.0067 0.157 0.157
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0051 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0346 0.0929
Schistosoma mansoni hypothetical protein 0.0022 0.0324 0.0324
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0504 0.0504
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0141 0.0377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0137
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Trypanosoma cruzi ribonuclease H1, putative 0.0018 0.0214 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0346 0.0346
Echinococcus multilocularis geminin 0.0371 1 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0141 0.0377
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0015 0.0141 0.0282
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0016 0.0042
Onchocerca volvulus 0.0015 0.0141 0.1745
Loa Loa (eye worm) hypothetical protein 0.0132 0.3387 0.9088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0346 0.0929
Brugia malayi acetyltransferase, GNAT family protein 0.013 0.3311 0.8884
Onchocerca volvulus 0.0028 0.0504 0.6835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0346 0.0929
Loa Loa (eye worm) carboxylesterase 0.0132 0.3387 0.9088
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0019 0.0256 0.128
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0063 0.0168
Schistosoma mansoni phosphoglucomutase 0.0018 0.0214 0.0214
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0015 0.0141 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0051 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0346 0.0346
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0018 0.0214 1
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0324 0.087
Onchocerca volvulus 0.0036 0.0731 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0776 0.6489
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.3387 0.3387
Loa Loa (eye worm) hypothetical protein 0.0015 0.0141 0.0377
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Schistosoma mansoni zinc finger protein 0.0011 0.0016 0.0016
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0036 0.0731 0.0731
Schistosoma mansoni hypothetical protein 0.0371 1 1
Schistosoma mansoni lamin 0.0017 0.0198 0.0198
Trypanosoma brucei ribonuclease H1 0.0018 0.0214 0.1002
Brugia malayi Carboxylesterase family protein 0.0036 0.0731 0.1961
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0531 0.0531
Brugia malayi ecdysteroid receptor 0.0023 0.0346 0.0929
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.004 0.004
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.3387 0.9088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Leishmania major ribonuclease H1, putative 0.0018 0.0214 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Echinococcus granulosus para nitrobenzyl esterase 0.0036 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0052 0.1163 0.312
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0016 0.0042
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0016 0.0016
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.3387 0.3387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0198 0.0532
Brugia malayi ecdysone receptor 0.0011 0.0016 0.0042
Echinococcus multilocularis lamin dm0 0.0017 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0141 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0051 0.0051
Schistosoma mansoni coup transcription factor 0.0023 0.0346 0.0346
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0016 0.0016
Onchocerca volvulus Ribonuclease H1 homolog 0.0018 0.0214 0.2771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0346 0.0346
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0346 0.0346
Echinococcus granulosus tumor protein p63 0.0193 0.5075 0.5075
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0016 0.0016
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0688 1
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0016 0.0042
Trypanosoma cruzi ribonuclease H1, putative 0.0018 0.0214 1
Brugia malayi nuclear receptor RXR 0.0012 0.0051 0.0137
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0346 0.0346
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0011 0.0034 0.0039
Chlamydia trachomatis glutamine binding protein 0.002 0.0262 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0051 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0346 0.0929
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0046 0.0987 0.0987
Echinococcus multilocularis BC026374 protein (S09 family) 0.0036 0.0731 0.0731
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0198 0.0532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0531 0.0531
Brugia malayi intermediate filament protein 0.0017 0.0198 0.0532
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0141 0.0244
Echinococcus multilocularis glutamate receptor 2 0.0012 0.004 0.004
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0012 0.004 0.004
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0046 0.0987 0.2649
Mycobacterium ulcerans carboxylesterase, LipT 0.0168 0.4384 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.1961
Brugia malayi hypothetical protein 0.0012 0.0051 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0346 0.0929
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0346 0.0346
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0731 0.0731
Echinococcus multilocularis neuroligin 0.0036 0.0731 0.0731
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0029 0.0531 0.1424
Trichomonas vaginalis ribonuclease H1, putative 0.0018 0.0214 0.2117
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0346 0.0929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0531 0.0531
Brugia malayi Intermediate filament tail domain containing protein 0.0017 0.0198 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0141 0.1243
Brugia malayi nuclear receptor NHR-88 0.0023 0.0346 0.0929
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0731 0.1634
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0141 0.5148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0063 0.0065
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0346 0.0929
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.002 0.0262 0.0561
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.002 0.0262 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0126 0.321 0.321
Brugia malayi Carboxylesterase family protein 0.0132 0.3387 0.9088
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0256 0.128
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0016 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0141 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0531 0.0531
Schistosoma mansoni nuclear receptor 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0346 0.0929
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0036 0.0731 0.936
Brugia malayi RNase H family protein 0.0018 0.0214 0.0574
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0731 0.1634
Loa Loa (eye worm) hypothetical protein 0.0015 0.0141 0.0377
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0052 0.1163 0.1163
Schistosoma mansoni glutamate receptor NMDA 0.0012 0.004 0.004
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0132 0.3387 0.9088
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0063 0.0168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0731 0.0731
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0029 0.0531 0.1424
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0036 0.0731 0.0731
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0141 0.0244
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0346 0.0346
Schistosoma mansoni phosphoglucomutase 0.0018 0.0214 0.0214
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0052 0.1163 0.1163
Trypanosoma brucei unspecified product 0.0019 0.0256 0.128
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0346 0.0346
Brugia malayi MH2 domain containing protein 0.0145 0.3727 1
Echinococcus granulosus carboxylesterase 5A 0.0132 0.3387 0.3387
Echinococcus granulosus neuropeptide receptor A26 0.0302 0.8073 0.8073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0189 0.0508
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0016 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0016 0.0016
Schistosoma mansoni BC026374 protein (S09 family) 0.0036 0.0731 0.0731
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0346 0.0929
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0346 0.0346
Schistosoma mansoni lamin 0.0017 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0346 0.0929
Brugia malayi nuclear hormone receptor 0.0023 0.0346 0.0929
Trypanosoma brucei ingi protein (ORF1) 0.0019 0.0256 0.128
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0346 0.0929
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0141 0.5148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0346 0.0929
Schistosoma mansoni neuroligin 3 (S09 family) 0.0036 0.0731 0.0731
Toxoplasma gondii ribonuclease HI protein 0.0018 0.0214 0.1374
Brugia malayi hypothetical protein 0.0036 0.0731 0.1961
Loa Loa (eye worm) carboxylesterase 0.0036 0.0731 0.1961
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0016
Brugia malayi conserved hypotetical protein 0.0011 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0137
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0015 0.0141 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0531 0.0531
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0016 0.0016
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0016 0.0042
Brugia malayi tailless protein 0.0011 0.0016 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0346 0.0929
Echinococcus multilocularis musashi 0.0017 0.0198 0.0198
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0776 0.6489
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0042
Schistosoma mansoni nuclear receptor 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0346 0.0929
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0052 0.1163 1
Loa Loa (eye worm) DR-78 0.0011 0.0016 0.0042
Echinococcus multilocularis lamin 0.0017 0.0198 0.0198
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0346 0.0346
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0052 0.1163 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0346 0.0346
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0016 0.0042
Echinococcus granulosus intermediate filament protein 0.0017 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0092
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.004 0.004

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.4 uM Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosphate production by scintillation proximity assay ChEMBL. 19419868
Emax (functional) < 50 % Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosphate production at 10 uM by scintillation proximity assay ChEMBL. 19419868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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