TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.43 | Formula: C21H21FN6
H donors: 1 H acceptors: 3 LogP: 3.39 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nccc(n1)c1c(nc2n1ccc(c2)C(N(C)C)C)c1ccc(cc1)F
InChi: 1S/C21H21FN6/c1-13(27(2)3)15-9-11-28-18(12-15)26-19(14-4-6-16(22)7-5-14)20(28)17-8-10-24-21(23)25-17/h4-13H,1-3H3,(H2,23,24,25)
InChiKey: YMYBQATUAYDJCL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Eimeria tenella	cGMP-dependent protein kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Brugia malayi	GnHR receptor homolog	0.0099	1	1
Echinococcus multilocularis	serotonin receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	neuropeptide receptor	0.0099	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.007	0.2656	0.2586
Echinococcus granulosus	tubulin beta 4A class IVa	0.007	0.2656	0.2586
Onchocerca volvulus		0.0099	1	0.5
Brugia malayi	putative neuropeptide receptor	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0099	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0099	1	1
Giardia lamblia	Beta tubulin	0.007	0.2656	0.5
Schistosoma mansoni	amine GPCR	0.0099	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0099	1	1
Schistosoma mansoni	biogenic amine receptor	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0099	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Brugia malayi	ORL1-like opioid receptor	0.0099	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.2656	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0099	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0099	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Schistosoma mansoni	biogenic amine receptor	0.0099	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.2656	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.007	0.2656	0.2586
Schistosoma mansoni	histamine h1 receptor	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0099	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.007	0.2656	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Brugia malayi	RE15519p	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0099	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0099	1	1
Schistosoma mansoni	hypothetical protein	0.0099	1	1
Brugia malayi	beta-tubulin, identical	0.007	0.2656	0.2586
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0099	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0099	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Schistosoma mansoni	amine GPCR	0.0099	1	1
Schistosoma mansoni	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Trypanosoma brucei	beta tubulin	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0099	1	1
Loa Loa (eye worm)	BEN-1 protein	0.007	0.2656	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0099	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0099	1	1
Trypanosoma brucei	beta tubulin	0.007	0.2656	0.5
Schistosoma mansoni	neuropeptide receptor	0.0099	1	1
Brugia malayi	Serotonin receptor	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Onchocerca volvulus		0.0099	1	0.5
Onchocerca volvulus		0.0099	1	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0099	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.007	0.2656	0.2586
Leishmania major	beta tubulin	0.007	0.2656	0.5
Brugia malayi	Tubulin beta-1 chain	0.007	0.2656	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	beta tubulin	0.007	0.2656	0.2586
Schistosoma mansoni	amine GPCR	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0099	1	1
Brugia malayi	G-protein coupled receptor	0.0099	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0099	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0099	1	1
Brugia malayi	Dopamine receptor protein 1	0.0099	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Brugia malayi	Serotonin receptor	0.0099	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0099	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0099	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	neuropeptide receptor	0.0099	1	1
Mycobacterium ulcerans	hypothetical protein	0.0059	0	0.5
Onchocerca volvulus		0.0099	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0099	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0099	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0099	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0099	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.007	0.2656	1
Onchocerca volvulus		0.0099	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.007	0.2656	0.2586
Entamoeba histolytica	tubulin family protein	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0099	1	1
Schistosoma mansoni	myosin xvIII	0.0099	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0099	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0099	1	1
Trypanosoma cruzi	beta tubulin, putative	0.007	0.2656	0.5
Loa Loa (eye worm)	tubulin beta-4 chain	0.007	0.2656	0.2586
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0099	1	1
Echinococcus granulosus	beta tubulin	0.007	0.2656	0.2586
Schistosoma mansoni	opsin-like receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.007	0.2656	0.2586
Echinococcus multilocularis	neuropeptides capa receptor	0.0099	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.007	0.2656	0.2586
Echinococcus multilocularis	sex peptide receptor	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Loa Loa (eye worm)	tubulin beta-2A chain	0.007	0.2656	0.2586
Echinococcus granulosus	neuropeptide receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0099	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0099	1	1
Schistosoma mansoni	opsin-like receptor	0.0099	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0099	1	1
Echinococcus granulosus	orexin receptor type 2	0.0099	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0099	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.007	0.2656	0.2586
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0099	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Brugia malayi	larval opioid receptor	0.0099	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	neuropeptide receptor	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	serotonin receptor	0.0099	1	1
Trypanosoma brucei	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	somatostatin receptor	0.0099	1	1
Schistosoma mansoni	adenoreceptor	0.0099	1	1
Brugia malayi	AKH receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0099	1	1
Brugia malayi	neuropeptide F receptor	0.0099	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0099	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	beta-tubulin	0.007	0.2656	0.2586
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0099	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0099	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0099	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0099	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0099	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	tubulin subunit beta	0.007	0.2656	0.2586
Echinococcus granulosus	g protein coupled receptor	0.0099	1	1
Echinococcus multilocularis	beta tubulin	0.007	0.2656	0.2586
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Echinococcus granulosus	g protein coupled receptor	0.0099	1	1
Brugia malayi	Melatonin receptor type 1A	0.0099	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0099	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Trichomonas vaginalis	tubulin, putative	0.007	0.2656	0.5
Echinococcus granulosus	fmrfamide receptor	0.0099	1	1
Brugia malayi	G-protein coupled receptor	0.0099	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	tubulin subunit beta	0.007	0.2656	0.2586
Echinococcus granulosus	neuropeptide receptor A26	0.0099	1	1
Giardia lamblia	Beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	g protein coupled receptor	0.0099	1	1
Loa Loa (eye worm)	tubulin beta chain	0.007	0.2656	0.2586
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	hypothetical protein	0.0099	1	1
Schistosoma mansoni	opsin-like receptor	0.0099	1	1
Schistosoma mansoni	hypothetical protein	0.0099	1	1
Toxoplasma gondii	beta tubulin	0.007	0.2656	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.007	0.2656	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0099	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	amine GPCR	0.0099	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2656	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0099	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0099	1	1
Brugia malayi	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0099	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0099	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0099	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.007	0.2656	0.2586
Echinococcus granulosus	beta tubulin	0.007	0.2656	0.2586
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0099	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus granulosus	sex peptide receptor	0.0099	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0099	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.007	0.2656	0.2586
Echinococcus granulosus	tm gpcr rhodopsin	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	biogenic amine receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0099	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0099	1	1
Schistosoma mansoni	amine GPCR	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0099	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0099	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0099	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0099	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Entamoeba histolytica	tubulin family protein	0.007	0.2656	0.5
Onchocerca volvulus		0.0099	1	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0099	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0099	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.007	0.2656	0.2586
Loa Loa (eye worm)	BEN-1 protein	0.007	0.2656	0.2586
Echinococcus multilocularis	neuropeptide receptor	0.0099	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0099	1	1
Leishmania major	beta tubulin	0.007	0.2656	0.5
Onchocerca volvulus		0.0099	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0099	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0099	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.007	0.2656	0.2586
Brugia malayi	Dopamine receptor	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Leishmania major	beta tubulin	0.007	0.2656	0.5
Trypanosoma brucei	beta tubulin	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	somatostatin receptor	0.0099	1	1
Onchocerca volvulus		0.0099	1	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0099	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0099	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0099	1	1
Echinococcus granulosus	serotonin receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0099	1	1
Plasmodium falciparum	tubulin beta chain	0.007	0.2656	1
Toxoplasma gondii	beta-tubulin, putative	0.007	0.2656	1
Plasmodium vivax	tubulin beta chain, putative	0.007	0.2656	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Giardia lamblia	Beta tubulin	0.007	0.2656	0.5
Onchocerca volvulus		0.0099	1	0.5
Brugia malayi	G protein-coupled receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0099	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.007	0.2656	0.2586
Leishmania major	beta tubulin	0.007	0.2656	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0099	1	1
Brugia malayi	sulfakinin receptor protein	0.0099	1	1
Schistosoma mansoni	tubulin subunit beta	0.007	0.2656	0.2586
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0099	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0099	1	1
Echinococcus granulosus	neuropeptide receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.2656	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1
Echinococcus granulosus	allatostatin A receptor	0.0099	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0099	1	1
Brugia malayi	neuropeptide F receptor	0.0099	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0099	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0099	1	1
Schistosoma mansoni	hypothetical protein	0.0099	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Brugia malayi	Dopamine receptor protein 2	0.0099	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0099	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.067 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	17981367
IC50 (binding)	= 0.09 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	17981367
IC50 (binding)	= 0.28 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	17981367

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL496148

Bibliographic References

No literature references available for this target.

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Detailed information for compound 995749