Detailed information for compound 996076

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.49 | Formula: C24H28N2O5
  • H donors: 2 H acceptors: 3 LogP: 3.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCCCOc1cc(O)c2c(c1)occ(c2=O)c1ccc(cc1)O
  • InChi: 1S/C24H28N2O5/c1-25-9-11-26(12-10-25)8-2-3-13-30-19-14-21(28)23-22(15-19)31-16-20(24(23)29)17-4-6-18(27)7-5-17/h4-7,14-16,27-28H,2-3,8-13H2,1H3
  • InChiKey: IETVSWBUUJCVJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Beta tubulin 0.0033 0.1158 0.2316
Trypanosoma cruzi beta tubulin, putative 0.0033 0.1158 0.4145
Leishmania major cytochrome p450-like protein 0.0057 0.2766 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0033 0.1158 0.2614
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.071 0.1604
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0057 0.2766 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0057 0.2766 1
Plasmodium falciparum alpha tubulin 2 0.0027 0.071 0.6071
Mycobacterium ulcerans hypothetical protein 0.0025 0.0583 0.1619
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.3052 0.3039
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0057 0.2766 1
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0021 0.0294 0.0955
Echinococcus granulosus Tubulin beta 2C chain 0.0033 0.1158 0.1141
Entamoeba histolytica tubulin family protein 0.0033 0.1158 0.7711
Echinococcus granulosus tubulin alpha 3 chain 0.0027 0.071 0.0692
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0583 0.3221
Echinococcus granulosus tubulin alpha 1C chain 0.0027 0.071 0.0692
Trypanosoma brucei cytochrome P450, putative 0.0057 0.2766 1
Trypanosoma brucei alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0027 0.071 0.1604
Onchocerca volvulus 0.0025 0.0583 0.5
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Mycobacterium leprae Conserved hypothetical protein 0.0057 0.2766 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0583 0.1912
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0057 0.2766 1
Echinococcus granulosus cytochrome P450 2K1 0.0057 0.2766 0.2752
Echinococcus granulosus tubulin beta 1 chain 0.0033 0.1158 0.1141
Echinococcus granulosus beta tubulin 0.0033 0.1158 0.1141
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0057 0.2766 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0162 0.1255
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0057 0.2766 1
Brugia malayi Cytochrome P450 family protein 0.0057 0.2766 0.9056
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0583 0.1861
Echinococcus granulosus Tubulin beta 2C chain 0.0033 0.1158 0.1141
Schistosoma mansoni tubulin subunit alpha 0.0027 0.071 0.0692
Brugia malayi Tubulin alpha-2 chain 0.0027 0.071 0.2279
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0057 0.2766 1
Brugia malayi Tubulin alpha-2 chain 0.0027 0.071 0.2279
Echinococcus granulosus tubulin alpha chain 0.0027 0.071 0.0692
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.4429 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Schistosoma mansoni alpha tubulin 0.0027 0.071 0.0692
Echinococcus multilocularis tubulin alpha chain 0.0027 0.071 0.0692
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.2766 0.9062
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0057 0.2766 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0583 0.1619
Echinococcus granulosus Tubulin beta 2C chain 0.0033 0.1158 0.1141
Echinococcus multilocularis tubulin alpha 0.0019 0.0172 0.0153
Trypanosoma cruzi cytochrome P450, putative 0.0057 0.2766 1
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Trichomonas vaginalis tubulin alpha chain, putative 0.0033 0.1158 0.2614
Trypanosoma brucei beta tubulin 0.0033 0.1158 0.4145
Trypanosoma brucei beta tubulin 0.0019 0.0172 0.0555
Echinococcus multilocularis tubulin alpha 1C chain 0.0027 0.071 0.0692
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.0172 0.0388
Trypanosoma brucei alpha tubulin 0.0027 0.071 0.2516
Echinococcus multilocularis Tubulin beta 2C chain 0.0033 0.1158 0.1141
Plasmodium falciparum tubulin gamma chain 0.0019 0.0172 0.134
Echinococcus multilocularis peroxisome assembly protein 26 0.0027 0.071 0.0692
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0057 0.2766 1
Loa Loa (eye worm) tubulin alpha 2 0.0019 0.0165 0.0541
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0057 0.2766 1
Brugia malayi Inositol-1 0.0038 0.145 0.4718
Trypanosoma cruzi epsilon tubulin, putative 0.0019 0.0172 0.0555
Echinococcus multilocularis beta tubulin 0.0033 0.1158 0.1141
Loa Loa (eye worm) tubulin beta-1 chain 0.0033 0.1158 0.3793
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.1185 0.4082
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0057 0.2766 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Loa Loa (eye worm) tubulin gamma chain 0.0019 0.0172 0.0563
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.3052 0.3039
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0583 0.2054
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.1158 0.2614
Echinococcus granulosus peroxisome assembly protein 26 0.0027 0.071 0.0692
Echinococcus granulosus tubulin alpha chain 0.0027 0.071 0.0692
Echinococcus granulosus tubulin subunit beta 0.0033 0.1158 0.1141
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0019 0.0165 0.0373
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.145 0.521
Loa Loa (eye worm) BEN-1 protein 0.0033 0.1158 0.3793
Schistosoma mansoni tubulin subunit gamma 0.0019 0.0172 0.0153
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Echinococcus multilocularis tubulin alpha chain 0.0027 0.071 0.0692
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0057 0.2766 1
Loa Loa (eye worm) cytochrome P450 0.0057 0.2766 0.9062
Brugia malayi beta-tubulin, identical 0.0033 0.1158 0.3754
Echinococcus granulosus tubulin subunit TubB 0.0027 0.071 0.0692
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Plasmodium vivax tubulin alpha chain, putative 0.0027 0.071 0.6071
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Echinococcus multilocularis Tubulin beta 2C chain 0.0033 0.1158 0.1141
Echinococcus granulosus Tubulin alpha 1 chain 0.0027 0.071 0.0692
Loa Loa (eye worm) hypothetical protein 0.0025 0.0583 0.1912
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Echinococcus granulosus tubulin alpha chain 0.0027 0.071 0.0692
Toxoplasma gondii alpha tubulin TUBA1 0.0027 0.071 0.2516
Plasmodium vivax tubulin alpha chain, putative 0.0027 0.071 0.6071
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.145 0.1434
Toxoplasma gondii beta-1 tubulin, putative 0.0033 0.1158 0.4145
Giardia lamblia Beta tubulin 0.0033 0.1158 0.2316
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Echinococcus granulosus tubulin beta 4A class IVa 0.0033 0.1158 0.1141
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.1185 0.2755
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Plasmodium falciparum tubulin epsilon chain, putative 0.0019 0.0172 0.134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0063
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0057 0.2766 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0063
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0583 0.1832
Brugia malayi Cytochrome P450 family protein 0.0057 0.2766 0.9056
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0583 0.1861
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0057 0.2766 1
Brugia malayi tubulin alpha chain - mouse 0.0027 0.071 0.2279
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0057 0.2766 1
Schistosoma mansoni hypothetical protein 0.0165 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Echinococcus granulosus tubulin alpha 3 chain 0.0027 0.071 0.0692
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Echinococcus multilocularis 0.0057 0.2766 0.2752
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0583 0.2054
Echinococcus multilocularis tubulin alpha chain 0.0027 0.071 0.0692
Leishmania major cytochrome p450-like protein 0.0057 0.2766 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0027 0.071 0.0692
Brugia malayi Cytochrome P450 family protein 0.0057 0.2766 0.9056
Loa Loa (eye worm) BEN-1 protein 0.0033 0.1158 0.3793
Brugia malayi Tubulin gamma chain 0.0019 0.0172 0.0503
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Schistosoma mansoni hypothetical protein 0.0165 1 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.145 0.5
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0057 0.2766 1
Entamoeba histolytica tubulin alpha-1 chain 0.0027 0.071 0.4212
Toxoplasma gondii alpha-tubulin I, putative 0.0027 0.071 0.2516
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0019 0.0172 0.0555
Trypanosoma brucei epsilon tubulin 0.0019 0.0172 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0531
Trypanosoma cruzi cytochrome P450, putative 0.0057 0.2766 1
Brugia malayi Cytochrome P450 family protein 0.0057 0.2766 0.9056
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Trichomonas vaginalis tubulin, putative 0.0033 0.1158 0.2614
Loa Loa (eye worm) tubulin alpha chain 0.0027 0.071 0.2327
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.2766 0.9062
Plasmodium vivax tubulin epsilon chain, putative 0.0019 0.0172 0.134
Echinococcus granulosus tubulin epsilon chain 0.0019 0.0172 0.0153
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0057 0.2766 1
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0583 0.1832
Echinococcus multilocularis tubulin beta 1 chain 0.0033 0.1158 0.1141
Trypanosoma brucei beta tubulin 0.0033 0.1158 0.4145
Echinococcus granulosus beta tubulin 0.0033 0.1158 0.1141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0583 0.1912
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Echinococcus granulosus tubulin alpha 0.0019 0.0172 0.0153
Echinococcus multilocularis Tubulin alpha 1 chain 0.0027 0.071 0.0692
Echinococcus multilocularis Tubulin beta 2C chain 0.0033 0.1158 0.1141
Echinococcus multilocularis hypothetical protein 0.0027 0.071 0.0692
Trypanosoma brucei epsilon tubulin 0.0019 0.0172 0.0555
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Echinococcus granulosus alpha tubulin 0.0027 0.071 0.0692
Trypanosoma cruzi alpha tubulin, putative 0.0027 0.071 0.2516
Brugia malayi cytochrome P450 0.0057 0.2766 0.9056
Giardia lamblia Alpha-tubulin 0.0027 0.071 0.1265
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0057 0.2766 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0057 0.2766 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0027 0.071 0.0692
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.145 0.521
Plasmodium falciparum tubulin beta chain 0.0033 0.1158 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0583 0.1619
Loa Loa (eye worm) hypothetical protein 0.0027 0.071 0.2327
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0063
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0057 0.2766 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0531
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Plasmodium vivax tubulin gamma chain, putative 0.0019 0.0172 0.134
Loa Loa (eye worm) tubulin alpha chain 0.0027 0.071 0.2327
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0531
Echinococcus multilocularis tubulin alpha 1C chain 0.0027 0.071 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Loa Loa (eye worm) inositol-1 0.0038 0.145 0.4752
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0057 0.2766 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.145 0.3274
Entamoeba histolytica tubulin family protein 0.0033 0.1158 0.7711
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.145 0.1434
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0583 0.1619
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.145 0.4947
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0583 0.3221
Loa Loa (eye worm) tubulin alpha-2 chain 0.0027 0.071 0.2327
Echinococcus multilocularis Tubulin alpha 1 chain 0.0027 0.071 0.0692
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.4429 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.145 0.521
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.3052 0.3039
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0057 0.2766 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0057 0.2766 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.3052 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0583 0.3221
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Giardia lamblia Alpha-tubulin 0.0027 0.071 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Loa Loa (eye worm) tubulin beta-4 chain 0.0033 0.1158 0.3793
Trypanosoma brucei alpha tubulin 0.0027 0.071 0.2516
Loa Loa (eye worm) tubulin beta-2A chain 0.0033 0.1158 0.3793
Echinococcus multilocularis tubulin alpha chain 0.0027 0.071 0.0692
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0541
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0057 0.2766 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0063
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Loa Loa (eye worm) alpha-tubulin 0.0027 0.071 0.2327
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0294 0.0663
Echinococcus multilocularis tubulin epsilon chain 0.0019 0.0172 0.0153
Schistosoma mansoni tubulin subunit alpha 0.0027 0.071 0.0692
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trypanosoma cruzi epsilon tubulin, putative 0.0019 0.0172 0.0555
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0057 0.2766 1
Schistosoma mansoni jumonji domain containing protein 0.0062 0.3052 0.3039
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0583 0.1861
Echinococcus multilocularis Tubulin alpha 1 chain 0.0027 0.071 0.0692
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0019 0.0165 0.0541
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0057 0.2766 1
Schistosoma mansoni alpha tubulin 0.0027 0.071 0.0692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0531
Toxoplasma gondii beta tubulin 0.0033 0.1158 0.4145
Trypanosoma cruzi tubulin gamma chain 0.0019 0.0172 0.0555
Plasmodium falciparum alpha tubulin 1 0.0027 0.071 0.6071
Loa Loa (eye worm) CYP4Cod1 0.0057 0.2766 0.9062
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Echinococcus multilocularis Tubulin beta 2C chain 0.0033 0.1158 0.1141
Toxoplasma gondii cytochrome p450 superfamily protein 0.0057 0.2766 1
Plasmodium vivax tubulin beta chain, putative 0.0033 0.1158 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0033 0.1158 0.1141
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0057 0.2766 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Schistosoma mansoni tubulin subunit epsilon 0.0019 0.0172 0.0153
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Entamoeba histolytica tubulin alpha chain, putative 0.0027 0.071 0.4212
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.4429 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0583 0.1619
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0057 0.2766 1
Loa Loa (eye worm) tubulin beta chain 0.0033 0.1158 0.3793
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.2766 0.9062
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0057 0.2766 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0057 0.2766 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0063
Echinococcus granulosus Tubulin beta 2C chain 0.0033 0.1158 0.1141
Toxoplasma gondii beta-tubulin, putative 0.0033 0.1158 0.4145
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0021 0.0294 0.0955
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.1158 0.2614
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.145 0.3274
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Schistosoma mansoni tubulin subunit alpha 0.0027 0.071 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.3052 0.689
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.145 1
Loa Loa (eye worm) alpha-tubulin 0.0027 0.071 0.2327
Echinococcus multilocularis beta tubulin 0.0033 0.1158 0.1141
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.4429 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0162 0.0255
Echinococcus granulosus tubulin gamma 1 chain 0.0019 0.0172 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0057 0.2766 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0057 0.2766 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.3052 0.3039
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0057 0.2766 1
Brugia malayi tubulin alpha-2 chain 0.0027 0.071 0.2279
Trypanosoma brucei beta tubulin 0.0033 0.1158 0.4145
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0583 0.1619
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Echinococcus granulosus tubulin alpha chain 0.0027 0.071 0.0692
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0057 0.2766 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0057 0.2766 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0531
Trypanosoma brucei epsilon tubulin 0.0019 0.0172 0.0555
Echinococcus granulosus tubulin alpha 1C chain 0.0027 0.071 0.0692
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0057 0.2766 1
Brugia malayi jmjC domain containing protein 0.0062 0.3052 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0583 0.2054
Echinococcus multilocularis tubulin subunit beta 0.0033 0.1158 0.1141
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.145 0.3274
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.3052 0.3039
Trypanosoma brucei beta tubulin 0.0033 0.1158 0.4145
Entamoeba histolytica hypothetical protein 0.0021 0.0294 0.0955
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0057 0.2766 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0027 0.071 0.0692
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0057 0.2766 1
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.145 0.521
Schistosoma mansoni cytochrome P450 0.0057 0.2766 0.2752
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0162 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0057 0.2766 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.071 0.1604
Brugia malayi Tubulin alpha chain 0.0027 0.071 0.2279
Schistosoma mansoni alpha tubulin 0.0027 0.071 0.0692
Brugia malayi Tubulin beta-1 chain 0.0033 0.1158 0.3754
Giardia lamblia Beta tubulin 0.0033 0.1158 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.145 0.521
Trypanosoma brucei alpha tubulin 0.0027 0.071 0.2516
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0057 0.2766 1
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.4429 1
Schistosoma mansoni tubulin subunit beta 0.0033 0.1158 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.1158 0.2614
Schistosoma mansoni inositol monophosphatase 0.0038 0.145 0.1434
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0172 0.0388
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Echinococcus granulosus Tubulin beta 2C chain 0.0033 0.1158 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Echinococcus granulosus tubulin alpha chain 0.0027 0.071 0.0692
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0057 0.2766 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0057 0.2766 1
Leishmania major cytochrome p450-like protein 0.0057 0.2766 1
Leishmania major epsilon tubulin, putative 0.0019 0.0172 0.0555
Echinococcus multilocularis geminin 0.0165 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0019 0.0165 0.0541
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0057 0.2766 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0057 0.2766 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.145 0.1434
Loa Loa (eye worm) beta-tubulin 0.0033 0.1158 0.3793
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0583 0.1619
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0162 0.1255
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0294 0.0663
Brugia malayi alpha-tubulin 0.0027 0.071 0.2279
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Echinococcus multilocularis tubulin subunit TubB 0.0027 0.071 0.0692
Leishmania major beta tubulin 0.0033 0.1158 0.4145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.3052 0.3039
Echinococcus multilocularis tubulin gamma 1 chain 0.0019 0.0172 0.0153
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.071 0.1604
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0172 0.0388
Echinococcus multilocularis tubulin alpha chain 0.0027 0.071 0.0692
Echinococcus granulosus Tubulin alpha 1 chain 0.0027 0.071 0.0692
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.4429 1
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.4429 1
Brugia malayi jmjC domain containing protein 0.0062 0.3052 1
Mycobacterium leprae putative cytochrome p450 0.0057 0.2766 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0057 0.2766 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0294 0.0663
Echinococcus multilocularis Tubulin beta 2C chain 0.0033 0.1158 0.1141
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0057 0.2766 1
Leishmania major gamma-tubulin 0.0019 0.0172 0.0555
Trypanosoma brucei tubulin gamma chain 0.0019 0.0172 0.0555
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0021 0.0294 0.0663
Leishmania major alpha tubulin 0.0027 0.071 0.2516
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663
Schistosoma mansoni hypothetical protein 0.0057 0.2766 0.2752
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0583 0.1619
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0294 0.0663

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 50 ug ml-1 Antibacterial activity against Escherichia coli after 24 hrs by MTT assay ChEMBL. 17977623
MIC (functional) > 50 ug ml-1 Antifungal activity against Candida albicans after 48 hrs by MTT assay ChEMBL. 17977623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.