Detailed information for compound 996183

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.83 | Formula: C18H22ClFN2O3
  • H donors: 0 H acceptors: 1 LogP: 2.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCOCc1ccc(cc1)COc1cnn(c(=O)c1Cl)C(C)(C)C
  • InChi: 1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3
  • InChiKey: RMXZKEPDYBTFOS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0367 0.0721 0.5074
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0085 0.0098 0.0046
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Chlamydia trachomatis DNA gyrase subunit A 0.0098 0.0126 0.0088
Mycobacterium tuberculosis Probable two component sensor kinase 0.0085 0.0098 0.0046
Leishmania major mitochondrial DNA topoisomerase II 0.1155 0.2466 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0367 0.0867
Brugia malayi glutaminase DH11.1 0.0271 0.0508 0.3515
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.0933 0.6636
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0106 0.0143 0.0046
Trichomonas vaginalis endoplasmin, putative 0.014 0.0218 0.1388
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0115 0.0163 0.0735
Mycobacterium tuberculosis Conserved protein 0.0085 0.0098 0.0046
Plasmodium vivax SET domain protein, putative 0.0066 0.0055 0.0079
Entamoeba histolytica DNA topoisomerase III, putative 0.0115 0.0163 0.0984
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0085 0.0098 0.0139
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0085 0.0098 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0085 0.0098 0.0046
Plasmodium falciparum DNA topoisomerase 2 0.067 0.1392 0.4095
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.058 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.0409 0.2791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Schistosoma mansoni ap endonuclease 0.0065 0.0051 0.0165
Echinococcus multilocularis heat shock protein 0.0191 0.0332 0.0778
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0967 0.2049 1
Loa Loa (eye worm) endoplasmin 0.0191 0.0332 0.2222
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Plasmodium vivax DNA gyrase subunit B, putative 0.1557 0.3357 1
Echinococcus multilocularis endoplasmin 0.0106 0.0143 0.0292
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Onchocerca volvulus 0.0066 0.0055 0.0227
Trichomonas vaginalis set domain proteins, putative 0.0527 0.1075 0.7675
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1557 0.3357 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Plasmodium vivax heat shock protein 86, putative 0.0191 0.0332 0.091
Trichomonas vaginalis glutaminase, putative 0.0271 0.0508 0.3515
Onchocerca volvulus 0.0527 0.1075 0.8985
Mycobacterium tuberculosis Possible two component sensor kinase 0.0085 0.0098 0.0046
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0085 0.0098 0.0139
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0085 0.0098 0.0176
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0115 0.0163 0.0984
Trichomonas vaginalis ap endonuclease, putative 0.0065 0.0051 0.0165
Mycobacterium ulcerans heat shock protein 90 0.0106 0.0143 0.0092
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0065 0.0051 0.0209
Trichomonas vaginalis heat shock protein, putative 0.014 0.0218 0.1388
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.4557 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0191 0.0332 0.2435
Treponema pallidum DNA topoisomerase I (topA) 0.0115 0.0163 0.0338
Trypanosoma brucei DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Echinococcus granulosus heat shock protein 90 0.0106 0.0143 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Giardia lamblia Pms1-like protein 0.0085 0.0098 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Entamoeba histolytica heat shock protein 90, putative 0.0191 0.0332 0.2222
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Schistosoma mansoni heat shock protein 0.0191 0.0332 0.2222
Mycobacterium ulcerans two component regulator - sensor kinase 0.0085 0.0098 0.0046
Plasmodium falciparum heat shock protein 90 0.0191 0.0332 0.091
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0085 0.0098 0.0046
Loa Loa (eye worm) heat shock protein 90 0.0191 0.0332 0.2222
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.002 0.0081
Mycobacterium ulcerans DNA gyrase subunit A 0.0434 0.0869 0.0822
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0115 0.0163 0.0984
Loa Loa (eye worm) hypothetical protein 0.0367 0.0721 0.5074
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0065 0.0051 0.0068
Entamoeba histolytica DNA topoisomerase III, putative 0.0115 0.0163 0.0984
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Entamoeba histolytica heat shock protein 90, putative 0.0191 0.0332 0.2222
Trichomonas vaginalis receptor histidine kinase, putative 0.0085 0.0098 0.0503
Chlamydia trachomatis DNA gyrase subunit A 0.0434 0.0869 0.2366
Mycobacterium ulcerans two component sensor kinase MprB 0.0085 0.0098 0.0046
Giardia lamblia Heat shock protein HSP 90-alpha 0.0106 0.0143 0.0793
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.067 0.1392 0.3499
Brugia malayi kinase, mitochondrial precursor 0.0085 0.0098 0.0503
Toxoplasma gondii heat shock protein 90, putative 0.0191 0.0332 0.1564
Trypanosoma cruzi heat shock protein 90, putative 0.0106 0.0143 0.0579
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Brugia malayi DNA topoisomerase II, alpha isozyme 0.067 0.1392 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0085 0.0098 0.0281
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0065 0.0261
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0261
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.056 0.227
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0217 0.077
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0115 0.0163 0.0984
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0555 0.1137 0.4612
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1557 0.3357 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0106 0.0143 0.0092
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.4557 1 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1155 0.2466 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0106 0.0143 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0085 0.0098 0.0046
Plasmodium falciparum DNA gyrase subunit A 0.0434 0.0869 0.2523
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0098 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.005 0.0154
Leishmania major DNA topoisomerase 1A 0.0115 0.0163 0.055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0478 0.0429
Trypanosoma cruzi DNA topoisomerase II, putative 0.0555 0.1137 0.4612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0055 0.0068
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Chlamydia trachomatis DNA gyrase subunit B 0.1557 0.3357 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Trypanosoma brucei heat shock protein 90, putative 0.0191 0.0332 0.1346
Loa Loa (eye worm) hypothetical protein 0.0226 0.0409 0.2791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0085 0.0098 0.0503
Plasmodium vivax endoplasmin, putative 0.0191 0.0332 0.091
Schistosoma mansoni ap endonuclease 0.0065 0.0051 0.0165
Trypanosoma brucei Heat shock protein 83, putative 0.0191 0.0332 0.1346
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0085 0.0098 0.0046
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0085 0.0098 0.0503
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.056 0.227
Toxoplasma gondii heat shock protein 75, putative 0.0054 0.0029 0.0076
Trichomonas vaginalis sensor histidine kinase, putative 0.0085 0.0098 0.0503
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0217 0.0879
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0036 0.0147
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0055 0.0194
Toxoplasma gondii Hsp90 domain-containing protein 0.0054 0.0029 0.0076
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0085 0.0098 0.0503
Brugia malayi DNA topoisomerase III 0.0115 0.0163 0.0984
Trypanosoma cruzi DNA topoisomerase II, putative 0.0555 0.1137 0.4612
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0115 0.0163 0.0984
Trypanosoma cruzi Heat shock protein 83, putative 0.0191 0.0332 0.1346
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0048 0.0196
Loa Loa (eye worm) hypothetical protein 0.0085 0.0098 0.0503
Onchocerca volvulus DNA topoisomerase 2 homolog 0.058 0.1193 1
Mycobacterium ulcerans putative regultory protein 0.0085 0.0098 0.0046
Brugia malayi Pre-SET motif family protein 0.0463 0.0933 0.6636
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0085 0.0098 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.0137 0.0211 0.0857
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0434 0.0869 0.2472
Toxoplasma gondii exonuclease III APE 0.0065 0.0051 0.0187
Leishmania major DNA topoisomerase III, putative 0.0115 0.0163 0.055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0055 0.0068
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0434 0.0869 0.0822
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.4557 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.1072 0.2284 0.6706
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Trichomonas vaginalis receptor histidine kinase, putative 0.0085 0.0098 0.0503
Loa Loa (eye worm) hypothetical protein 0.0066 0.0055 0.0194
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0217 0.0879
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0085 0.0098 0.0413
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Plasmodium falciparum DNA gyrase subunit B 0.1557 0.3357 1
Leishmania major DNA topoisomerase III, putative 0.0115 0.0163 0.055
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0434 0.0869 0.4202
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0085 0.0098 0.0206
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0523 0.1066 0.0978
Brugia malayi hypothetical protein 0.0071 0.0065 0.0261
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0085 0.0098 0.0503
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0115 0.0163 0.0984
Loa Loa (eye worm) TOPoisomerase family member 0.067 0.1392 1
Brugia malayi Pre-SET motif family protein 0.0066 0.0055 0.0194
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.056 0.2178
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0085 0.0098 0.0046
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1813 0.3924 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0367 0.2477
Schistosoma mansoni hypothetical protein 0.0198 0.0348 0.2337
Trypanosoma brucei developmentally regulated phosphoprotein 0.0085 0.0098 0.0396
Echinococcus multilocularis rho GTPase activating protein 20 0.0115 0.0163 0.0344
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0085 0.0098 0.0046
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0085 0.0098 0.0046
Echinococcus granulosus geminin 0.0198 0.0348 0.2337
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0065 0.0091
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Loa Loa (eye worm) glutaminase 0.0271 0.0508 0.3515
Leishmania major DNA topoisomerase ii 0.0555 0.1137 0.4548
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0085 0.0098 0.0396
Schistosoma mansoni DNA topoisomerase II 0.067 0.1392 1
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0065 0.0051 0.0209
Plasmodium vivax DNA gyrase subunit A, putative 0.0434 0.0869 0.2523
Trypanosoma cruzi heat shock protein, putative 0.0054 0.0029 0.0118
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0065 0.0051 0.0092
Trypanosoma brucei DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0085 0.0098 0.0046
Mycobacterium ulcerans glutaminase 0.0271 0.0508 0.0459
Mycobacterium ulcerans DNA topoisomerase I 0.0115 0.0163 0.0112
Brugia malayi GRF zinc finger family protein 0.0115 0.0163 0.0984
Plasmodium falciparum endoplasmin, putative 0.014 0.0218 0.0568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Loa Loa (eye worm) DNA topoisomerase III 0.0115 0.0163 0.0984
Schistosoma mansoni heat shock protein 0.0191 0.0332 0.2222
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0085 0.0098 0.0396
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0106 0.0143 0.0467
Mycobacterium ulcerans hypothetical protein 0.0155 0.0252 0.0201
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0085 0.0098 0.0503
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0555 0.1137 0.4612
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0065 0.0051 0.0165
Trichomonas vaginalis heat shock protein, putative 0.0191 0.0332 0.2222
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0085 0.0098 0.0046
Giardia lamblia DNA topoisomerase II 0.0584 0.1203 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Mycobacterium ulcerans DNA gyrase subunit B 0.1557 0.3357 0.3323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Treponema pallidum heat shock protein 90 0.0106 0.0143 0.0276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0252 0.0201
Echinococcus granulosus endoplasmin 0.0106 0.0143 0.0835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0367 0.2477
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0085 0.0098 0.0503
Trypanosoma cruzi heat shock protein 85, putative 0.0106 0.0143 0.0579
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0434 0.0869 0.2472
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0085 0.0098 0.0046
Brugia malayi Probable DNA topoisomerase II 0.067 0.1392 1
Onchocerca volvulus 0.0115 0.0163 0.1152
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0207 0.0367 0.2477
Echinococcus multilocularis heat shock protein 90 0.0106 0.0143 0.0292
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0115 0.0163 0.0344
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1557 0.3357 0.3323
Plasmodium vivax DNA topoisomerase II, putative 0.067 0.1392 0.4095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0065 0.0261
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0115 0.0163 0.0984
Trypanosoma brucei DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Echinococcus granulosus heat shock protein 0.0191 0.0332 0.2222
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Brugia malayi Endoplasmin precursor 0.0191 0.0332 0.2222
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0018 0.0075
Brugia malayi exodeoxyribonuclease III family protein 0.0065 0.0051 0.0165
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0055 0.0206
Schistosoma mansoni hypothetical protein 0.0198 0.0348 0.2337
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.056 0.227
Echinococcus multilocularis geminin 0.0198 0.0348 0.0818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.067 0.1392 1
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Echinococcus multilocularis heat shock protein 90 0.0191 0.0332 0.0778
Toxoplasma gondii DNA topoisomerase 2, putative 0.067 0.1392 0.6772
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Onchocerca volvulus DNA topoisomerase 2 homolog 0.058 0.1193 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0085 0.0098 0.0396
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0085 0.0098 0.0046
Schistosoma mansoni endoplasmin 0.0191 0.0332 0.2222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0207 0.0367 0.2477
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0055 0.0194
Brugia malayi heat shock protein 90 0.0191 0.0332 0.2222
Plasmodium falciparum DNA topoisomerase 3, putative 0.0115 0.0163 0.0403
Schistosoma mansoni glutaminase 0.0271 0.0508 0.3515
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0115 0.0163 0.0984
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0115 0.0163 0.0066
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0106 0.0143 0.0276
Giardia lamblia DNA topoisomerase III 0.0115 0.0163 0.097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0065 0.0051 0.0165
Giardia lamblia DNA topoisomerase III 0.0115 0.0163 0.097
Brugia malayi DNA topoisomerase III beta-1 0.0115 0.0163 0.0984
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Trichomonas vaginalis DNA topoisomerase II, putative 0.067 0.1392 1
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0085 0.0098 0.0176
Chlamydia trachomatis DNA topoisomerase I 0.0115 0.0163 0.0201
Plasmodium vivax DNA topoisomerase 3, putative 0.0115 0.0163 0.0403
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0085 0.0098 0.0046
Echinococcus granulosus DNA topoisomerase 2 alpha 0.067 0.1392 1
Trypanosoma brucei heat shock protein 90, putative 0.0191 0.0332 0.1346
Loa Loa (eye worm) glutaminase 2 0.0271 0.0508 0.3515
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0065 0.0051 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0367 0.0867
Toxoplasma gondii heat shock protein HSP90 0.0191 0.0332 0.1564
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0085 0.0098 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Toxoplasma gondii DNA topoisomerase family protein 0.0115 0.0163 0.0735
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0085 0.0098 0.0046
Schistosoma mansoni pyruvate dehydrogenase 0.0085 0.0098 0.0503
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0065 0.0051 0.0058
Schistosoma mansoni endoplasmin 0.0191 0.0332 0.2222
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi heat shock protein 90, putative 0.0191 0.0332 0.1346
Entamoeba histolytica DNA topoisomerase II, putative 0.067 0.1392 1
Trichomonas vaginalis ap endonuclease, putative 0.0065 0.0051 0.0165
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1155 0.2466 1
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Giardia lamblia Grp94/Hsp90 0.0106 0.0143 0.0793
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Leishmania major hypothetical protein, conserved 0.0085 0.0098 0.0281
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0085 0.0098 0.0413
Trypanosoma brucei DNA topoisomerase ii 0.1155 0.2466 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0085 0.0098 0.0046
Trypanosoma brucei heat shock protein 84, putative 0.0054 0.0029 0.0118
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0115 0.0163 0.0338
Echinococcus granulosus heat shock protein 90 0.0191 0.0332 0.2222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0065 0.0051 0.0068
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0178 0.0303 0.0208
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0085 0.0098 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0065 0.0051 0.0165

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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