Detailed information for compound 996251

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.543 | Formula: C26H30N4
  • H donors: 2 H acceptors: 0 LogP: 5.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)[nH]cc2[C@@H]1CC[C@H](CC1)N1CCN(CC1)c1cccc2c1cc[nH]2
  • InChi: 1S/C26H30N4/c1-2-5-24-21(4-1)23(18-28-24)19-8-10-20(11-9-19)29-14-16-30(17-15-29)26-7-3-6-25-22(26)12-13-27-25/h1-7,12-13,18-20,27-28H,8-11,14-17H2/t19-,20-
  • InChiKey: PKKXQKIYTJVFFJ-MXVIHJGJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.0597 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.0597 0.0859
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0172 0.0976 0.0976
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0108 0.0108
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0342 0.0492
Echinococcus multilocularis geminin 0.0172 0.0976 0.1015
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.0597 0.0597
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0216 0.031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.0597 0.0621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0172 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0597 0.0597
Entamoeba histolytica hypothetical protein 0.0037 0.0108 0.0156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0597 0.0859
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0216 0.031
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0216 0.031
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1521 0.9618 1
Brugia malayi Flap endonuclease-1 0.0026 0.0044 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.0597 0.0859
Entamoeba histolytica hypothetical protein 0.0037 0.0108 0.0156
Schistosoma mansoni biogenic amine (5HT) receptor 0.015 0.0835 0.0835
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1105 0.6955 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0597 0.0597
Schistosoma mansoni nuclear receptor 0.0053 0.0216 0.0216
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.0597 0.0621
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1105 0.6955 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.0597 0.0859
Entamoeba histolytica hypothetical protein 0.0037 0.0108 0.0156
Echinococcus multilocularis dna polymerase eta 0.0045 0.0166 0.0172
Echinococcus granulosus transcription factor Dp 1 0.064 0.3973 0.3973
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0216 0.031
Brugia malayi ecdysone receptor 0.0053 0.0216 0.031
Echinococcus multilocularis serotonin receptor 0.015 0.0835 0.0868
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Loa Loa (eye worm) hypothetical protein 0.006 0.0256 0.0369
Loa Loa (eye worm) hypothetical protein 0.0073 0.0342 0.0492
Entamoeba histolytica hypothetical protein 0.0037 0.0108 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.0597 0.0597
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0286 0.0412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0108 0.0113
Brugia malayi nuclear receptor NHR-67 0.0053 0.0216 0.031
Plasmodium falciparum flap endonuclease 1 0.0026 0.0044 1
Schistosoma mansoni coup transcription factor 0.0113 0.0597 0.0597
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0044 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.0597 0.0597
Brugia malayi hypothetical protein 0.0026 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.015 0.0835 0.1201
Brugia malayi hypothetical protein 0.0053 0.0216 0.031
Brugia malayi tailless protein 0.0053 0.0216 0.031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Schistosoma mansoni DNA polymerase eta 0.0045 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.0597 0.0597
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.0597 0.0621
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1105 0.6955 0.6955
Loa Loa (eye worm) hypothetical protein 0.006 0.0256 0.0369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0216 0.0224
Loa Loa (eye worm) DR-78 0.0053 0.0216 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.0597 0.0859
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0079 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1105 0.6955 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1105 0.6955 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.0597 0.0597
Schistosoma mansoni flap endonuclease-1 0.0024 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0342 0.5
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0044 1
Echinococcus granulosus FTZ F1 alpha 0.0113 0.0597 0.0597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0597 0.0621
Loa Loa (eye worm) hypothetical protein 0.0073 0.0342 0.0492
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.0597 0.0859
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.0597 0.0597
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.0597 0.0597
Echinococcus granulosus dna polymerase eta 0.0045 0.0166 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0597 0.0597
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0597 0.0859
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0216 0.0216
Brugia malayi nuclear receptor NHR-88 0.0053 0.0216 0.031
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0342 0.0342
Onchocerca volvulus Bile acid receptor homolog 0.0113 0.0597 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.0597 0.0597
Brugia malayi hypothetical protein 0.006 0.0256 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0216 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.0597 0.0859
Brugia malayi nuclear receptor NHR-88 0.0113 0.0597 0.0859
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.0597 1
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Brugia malayi TAR-binding protein 0.0064 0.0286 0.0412
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0216 0.031
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0216 0.031
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0342 0.0492
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0044 0.1335
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0256 0.0256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0216 0.0216
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0079 0.0114
Echinococcus granulosus serotonin transporter 0.0073 0.0342 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.0597 0.0859
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0216 0.0224
Brugia malayi nuclear receptor RXR 0.0053 0.0216 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0172 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0172 0.0172
Schistosoma mansoni zinc finger protein 0.0053 0.0216 0.0216
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0342 0.0492
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0286 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.0597 0.0859
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1105 0.6955 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0597 0.0621
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.0597 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0038 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0172 0.0179
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.0597 0.0597
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.0597 0.0597
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0166 0.0238
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0216 0.0224
Echinococcus multilocularis transcription factor Dp 1 0.064 0.3973 0.4131
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0172 0.0247
Echinococcus multilocularis serotonin transporter 0.0073 0.0342 0.0356
Brugia malayi conserved hypotetical protein 0.0053 0.0216 0.031
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0 0.5
Brugia malayi ecdysteroid receptor 0.0113 0.0597 0.0859
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0172 0.0172
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0597 0.0597
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.1105 0.6955 1
Echinococcus multilocularis serotonin receptor 0.015 0.0835 0.0868
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0055
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0166 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.0597 0.0859
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.0597 0.0621
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0216 0.0216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0597 0.0859
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.006 0.0256 0.0369
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1105 0.6955 0.7231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0216 0.0216
Onchocerca volvulus 0.0073 0.0342 0.3316
Loa Loa (eye worm) hypothetical protein 0.0073 0.0342 0.0492
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0216 0.0224
Echinococcus granulosus geminin 0.0172 0.0976 0.0976
Schistosoma mansoni nuclear receptor 0.0053 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0172 0.0247
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0597 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0256 0.0369
Brugia malayi nuclear receptor RXR 0.006 0.0256 0.0369
Loa Loa (eye worm) hypothetical protein 0.006 0.0256 0.0369
Brugia malayi nuclear hormone receptor 0.0053 0.0216 0.031
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0256 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.0597 0.0859
Brugia malayi steroid hormone receptor 0.0113 0.0597 0.0859
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0044 0.0046
Schistosoma mansoni hypothetical protein 0.0172 0.0976 0.0976
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1105 0.6955 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1105 0.6955 0.6955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.0597 0.0859
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0597 0.0597
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0256 0.0267
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Leishmania major DNA polymerase eta, putative 0.0045 0.0166 0.0238
Leishmania major hypothetical protein, conserved 0.0026 0.0038 0.0055
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0286 0.0298
Brugia malayi hypothetical protein 0.0037 0.0108 0.0156
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.0108 0.0108
Brugia malayi nuclear hormone receptor 0.0113 0.0597 0.0859
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.0597 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0597 0.0859
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0216 0.031
Brugia malayi hypothetical protein 0.006 0.0256 0.0369
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0256 0.0369
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0166 0.0238
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0216 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0286 0.0286
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0216 0.031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0286 0.0412
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0597 0.0859
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0216 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0286 0.0286
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0342 0.0492
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.0055
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0216 0.031
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0597 0.0859
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.0597 0.0621
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0063
Onchocerca volvulus 0.0113 0.0597 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0835 0.1201
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.0597 0.0859
Schistosoma mansoni retinoic acid receptor RXR 0.1581 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0256 0.0369
Loa Loa (eye worm) hypothetical protein 0.0045 0.0166 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0286 0.0286
Brugia malayi hypothetical protein 0.0053 0.0216 0.031
Echinococcus granulosus tar DNA binding protein 0.0064 0.0286 0.0286
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.0597 0.0597
Brugia malayi RNA binding protein 0.0064 0.0286 0.0412
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0286 0.0286
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0256 0.0256
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0 0.5
Leishmania major DNA polymerase eta, putative 0.0032 0.0079 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0172 0.0179
Echinococcus granulosus biogenic amine 5HT receptor 0.015 0.0835 0.0835
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0286 0.0286
Echinococcus granulosus flap endonuclease 1 0.0026 0.0044 0.0044
Loa Loa (eye worm) RNA binding protein 0.0064 0.0286 0.0412
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.0597 0.0859
Loa Loa (eye worm) hypothetical protein 0.006 0.0256 0.0369
Loa Loa (eye worm) hypothetical protein 0.0053 0.0216 0.031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.0597 0.0859

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.3 nM Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells ChEMBL. 18571421
Ki (binding) = 155 nM Displacement of [3H]paroxetine from rat cortical 5HTT reuptake site ChEMBL. 18571421

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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