Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.2597 | 0.4411 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.035 | 0.0382 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0144 | 0.5108 | 0.5108 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | subgroup IIIi aminotransferase, putative | 0.0093 | 0.3059 | 0.5 |
Giardia lamblia | Branched-chain amino acid aminotransferase lateral transfer candidate | 0.0093 | 0.3059 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2597 | 0.2597 |
Plasmodium vivax | aminodeoxychorismate lyase, putative | 0.0027 | 0.0389 | 1 |
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 1 |
Brugia malayi | Branched-chain amino acid aminotransferase, cytosolic, putative | 0.0093 | 0.3059 | 0.3342 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.2597 | 0.2836 |
Plasmodium falciparum | aminodeoxychorismate lyase | 0.0027 | 0.0389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5108 | 0.5579 |
Mycobacterium leprae | PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE | 0.0093 | 0.3059 | 0.5 |
Toxoplasma gondii | Branched-chain-amino-acid aminotransferase | 0.0093 | 0.3059 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5886 | 1 |
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0245 | 0.9155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2597 | 0.2836 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Echinococcus multilocularis | muscleblind protein | 0.0144 | 0.5108 | 0.5108 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5886 | 0.5886 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5886 | 1 |
Trypanosoma brucei | Aminotransferase class IV, putative | 0.0027 | 0.0389 | 0.0144 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0389 | 0.0144 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2597 | 0.2836 |
Mycobacterium tuberculosis | Branched-chain amino acid transaminase IlvE | 0.0093 | 0.3059 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.035 | 0.0382 |
Mycobacterium ulcerans | branched-chain amino acid aminotransferase | 0.0093 | 0.3059 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2597 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5108 | 0.5579 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2597 | 0.2597 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0266 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.2597 | 0.2597 |
Echinococcus granulosus | muscleblind protein | 0.0144 | 0.5108 | 0.5108 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.9155 | 1 |
Loa Loa (eye worm) | branched-chain amino acid aminotransferase | 0.0093 | 0.3059 | 0.3342 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2597 | 0.2836 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2597 | 0.2836 |
Echinococcus granulosus | geminin | 0.0164 | 0.5886 | 0.5886 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.2597 | 0.2597 |
Entamoeba histolytica | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.2597 | 0.2836 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0389 | 0.0144 |
Brugia malayi | Muscleblind-like protein | 0.0144 | 0.5108 | 0.5579 |
Leishmania major | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 1 |
Trichomonas vaginalis | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 0.5 |
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.0093 | 0.3059 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | Aminotransferase class IV, putative | 0.0027 | 0.0389 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2597 | 0.2597 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 uM | Inhibition of butyrylcholinesterase | ChEMBL. | 18681480 |
IC50 (functional) | = 6.8 uM | Antileishmanial activity against Leishmania major | ChEMBL. | 18681480 |
IC50 (binding) | = 24.2 uM | Inhibition of acetylcholinesterase | ChEMBL. | 18681480 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania major | ChEMBL23 | 18681480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.