Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0304 | 0.5933 | 0.5933 |
Trypanosoma brucei | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0167 | 0.2716 | 0.2716 |
Echinococcus granulosus | acetylcholinesterase | 0.0304 | 0.5933 | 0.5933 |
Echinococcus granulosus | carboxylesterase 5A | 0.0304 | 0.5933 | 0.5933 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0.0006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | neuroligin | 0.0051 | 0.0006 | 0.0006 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0477 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0167 | 0.2716 | 0.2716 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.045 | 0.9377 | 0.9377 |
Onchocerca volvulus | 0.0051 | 0.0006 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0477 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0.0006 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0051 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0051 | 0.0006 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0477 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | acetylcholinesterase | 0.0304 | 0.5933 | 0.5933 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0055 | 0.01 | 0.01 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0.0006 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Brugia malayi | Carboxylesterase family protein | 0.0304 | 0.5933 | 0.5933 |
Schistosoma mansoni | acetylcholinesterase | 0.0051 | 0.0006 | 0.0006 |
Leishmania major | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0167 | 0.2716 | 0.2716 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0051 | 0.0006 | 0.0006 |
Echinococcus granulosus | neuroligin | 0.0051 | 0.0006 | 0.0006 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | gliotactin | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0304 | 0.5933 | 0.5933 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | lipoxygenase | 0.0055 | 0.01 | 0.01 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0006 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase kinase, putative | 0.0167 | 0.2716 | 0.8134 |
Onchocerca volvulus | 0.0051 | 0.0006 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Echinococcus multilocularis | acetylcholinesterase | 0.0304 | 0.5933 | 0.5933 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0.0006 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.5933 | 0.5933 |
Onchocerca volvulus | 0.0051 | 0.0006 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | carboxylesterase | 0.0304 | 0.5933 | 0.5933 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0006 | 0.0006 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.045 | 0.9377 | 0.9377 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0477 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 1 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0477 | 1 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0477 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0193 | 0.3339 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0055 | 0.01 | 0.01 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0006 | 0.0006 |
Echinococcus granulosus | acetylcholinesterase | 0.0304 | 0.5933 | 0.5933 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0304 | 0.5933 | 0.5933 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.5933 | 0.5933 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0006 | 0.0006 |
Brugia malayi | Carboxylesterase family protein | 0.0304 | 0.5933 | 0.5933 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0051 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0051 | 0.0006 | 0.5 | |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0477 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.