Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5517 | 0.5956 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3392 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.3684 | 0.2714 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3392 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3392 | 0.382 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.1067 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.049 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.4188 | 0.3419 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.4188 | 0.3419 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.3684 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.284 | 0.3066 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.5517 | 0.4813 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1067 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3392 | 0.382 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2253 | 0.2432 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0696 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.888 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3258 | 0.3669 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.1067 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.5517 | 0.4813 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3392 | 0.382 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.888 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3258 | 0.3669 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4417 | 0.4769 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7978 | 0.8984 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.888 | 0.8704 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4087 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3679 | 0.3972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.3684 | 0.2714 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3392 | 0.382 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3392 | 0.2356 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3684 | 0.3978 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.888 | 0.9588 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.284 | 0.1717 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.284 | 0.3198 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.3684 | 0.2694 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 0.8288 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.888 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3392 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.5517 | 0.5956 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 0.8288 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.049 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.4188 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3667 | 0.2673 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3392 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0106 | 0.0114 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9262 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.5 | Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells | ChEMBL. | 18571922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.