Detailed information for compound 996465

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 528.131 | Formula: C32H38ClN5
  • H donors: 2 H acceptors: 1 LogP: 7.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc2c(c1)nccc2Nn1c(C)c(cc1c1ccccc1)CNCC[C@@H]1CCCN2[C@@H]1CCCC2
  • InChi: 1S/C32H38ClN5/c1-23-26(22-34-16-14-25-10-7-19-37-18-6-5-11-31(25)37)20-32(24-8-3-2-4-9-24)38(23)36-29-15-17-35-30-21-27(33)12-13-28(29)30/h2-4,8-9,12-13,15,17,20-21,25,31,34H,5-7,10-11,14,16,18-19,22H2,1H3,(H,35,36)/t25-,31+/m0/s1
  • InChiKey: YLTFPNHAWXRRBI-VVFBEHOQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0117 0.0385
Plasmodium vivax vivapain-2 0.0033 0.0153 0.0919
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0117 0.0117
Brugia malayi Heterochromatin protein 1 0.0069 0.0412 0.1395
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0117 0.0113
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0165 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1282 0.1282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0133
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0117 0.0117
Schistosoma mansoni neuropeptide receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0117 0.0385
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0343 0.2656
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0117 0.0113
Onchocerca volvulus 0.0033 0.0153 0.0443
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus multilocularis caspase 0.0121 0.0786 0.0782
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.0656 0.0756
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0117 0.0113
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) TAR-binding protein 0.0386 0.269 0.9109
Schistosoma mansoni ferritin light chain 0.0025 0.0098 0.0098
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0117 0.0113
Echinococcus multilocularis peregrin 0.0036 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Giardia lamblia PHD finger protein 15 0.0028 0.0122 0.2317
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0117 0.0113
Brugia malayi RE15519p 0.0028 0.0117 0.0397
Brugia malayi ORL1-like opioid receptor 0.0028 0.0117 0.0397
Echinococcus multilocularis tar DNA binding protein 0.0386 0.269 0.2687
Trypanosoma cruzi metacaspase, putative 0.0046 0.0246 0.1893
Schistosoma mansoni apoferritin-2 0.0025 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0241
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0471
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0117 0.0113
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0004 0.0013
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0117 0.0117
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0114 0.0737 0.5735
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0117 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Plasmodium vivax metacaspase 1, putative 0.0046 0.0246 0.1666
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0117 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0117 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Brugia malayi MH2 domain containing protein 0.0117 0.076 0.2575
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0153 0.2412
Echinococcus multilocularis cysteine protease 0.0033 0.0153 0.0149
Brugia malayi Cell death protein 3 precursor 0.0088 0.0552 0.1869
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0246 0.1893
Schistosoma mansoni ferritin 0.0025 0.0098 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.1629 0.1629
Onchocerca volvulus 0.0028 0.0117 0.0337
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0039 0.0035
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0117 0.0113
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0586 0.0583
Trypanosoma brucei metacaspase 0.0046 0.0246 0.1893
Trypanosoma cruzi metacaspase, putative 0.0046 0.0246 0.1893
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0153 0.2412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Onchocerca volvulus 0.0033 0.0153 0.0443
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0117 0.0113
Schistosoma mansoni chromobox protein 0.0069 0.0412 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0353 0.0353
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0343 0.0393
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0353 0.0349
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.1282 0.1481
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0743 0.0739
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0117 0.0113
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Brugia malayi G-protein coupled receptor 0.0028 0.0117 0.0397
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0444
Plasmodium vivax hypothetical protein, conserved 0.019 0.1282 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0117 0.0117
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0153 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1282 1
Brugia malayi Inositol-1 0.0115 0.0743 0.2516
Brugia malayi beta-lactamase family protein 0.019 0.1282 0.4343
Brugia malayi hypothetical protein 0.0043 0.0223 0.0756
Schistosoma mansoni caspase-7 (C14 family) 0.0121 0.0786 0.0786
Brugia malayi Stress-activated protein kinase jnk-1 0.0239 0.1629 0.5518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0117 0.0385
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0086 0.064
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0743 0.5782
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0117 0.0113
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0743 0.5782
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0039 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Trichomonas vaginalis esterase, putative 0.019 0.1282 0.3796
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0117 0.0113
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0239 0.1629 0.1626
Echinococcus multilocularis sex peptide receptor 0.0028 0.0117 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0241
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0098 0.0736
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Brugia malayi G protein-coupled receptor 0.0028 0.0117 0.0397
Echinococcus granulosus tumor protein p63 0.0692 0.4879 0.4877
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0117 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0037
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0098 0.0109
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0647
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0566 0.167
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Brugia malayi neuropeptide F receptor 0.0028 0.0117 0.0397
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0165 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus orexin receptor type 2 0.0028 0.0117 0.0113
Onchocerca volvulus 0.0028 0.0117 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0815 0.6344
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0075 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0117 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0566 0.0563
Schistosoma mansoni amine GPCR 0.0028 0.0117 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.029
Brugia malayi SET domain containing protein 0.0014 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0061 0.0353 0.1183
Brugia malayi Pre-SET motif family protein 0.0061 0.0353 0.1194
Brugia malayi putative neuropeptide receptor 0.0028 0.0117 0.0397
Echinococcus multilocularis somatostatin receptor 0.0028 0.0117 0.0113
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0039 0.0272
Brugia malayi G-protein coupled receptor 0.0028 0.0117 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0075 0.0211
Brugia malayi Cathepsin L-like precursor 0.0022 0.0075 0.0254
Schistosoma mansoni chromobox protein 0.0069 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0343 0.034
Schistosoma mansoni ferritin light chain 0.0025 0.0098 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.064
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0043 0.0093
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0566 0.167
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0216 0.0629
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0117 0.0117
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0412 0.1384
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni tar DNA-binding protein 0.0386 0.269 0.269
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0117 0.0117
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0117 0.0113
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0117 0.0113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.1282 0.1481
Schistosoma mansoni myosin xvIII 0.0028 0.0117 0.0117
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0117 0.0113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0153 0.0505
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0117 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0117 0.0113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0039 0.0039
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0194 0.0566
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0039 0.0471
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.2952 1
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.1282 0.1279
Onchocerca volvulus 0.0028 0.0117 0.0337
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0117 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0153 0.0443
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0043 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0412 0.1212
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0117 0.0113
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0117 0.0113
Brugia malayi AKH receptor 0.0028 0.0117 0.0397
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0117 0.0397
Echinococcus granulosus cathepsin L 0.0017 0.0039 0.0035
Mycobacterium tuberculosis Conserved protein 0.019 0.1282 0.1481
Schistosoma mansoni opsin-like receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Onchocerca volvulus 0.0023 0.0086 0.0243
Brugia malayi Melatonin receptor type 1A 0.0028 0.0117 0.0397
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0153 0.0153
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0223 0.022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.0656 0.5106
Loa Loa (eye worm) hypothetical protein 0.0101 0.0643 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0114 0.0326
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0223 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0086 0.064
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0039 0.0272
Plasmodium vivax vivapain-2 0.0033 0.0153 0.0919
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0153 0.0443
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Onchocerca volvulus 0.0028 0.0117 0.0337
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.076 0.2565
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Leishmania major metacaspase, putative 0.0046 0.0246 0.1893
Schistosoma mansoni inositol monophosphatase 0.0115 0.0743 0.0743
Brugia malayi Serotonin receptor 0.0028 0.0117 0.0397
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0004 0.0013
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0117 0.0397
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0153 0.0443
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus caspase 3 0.0075 0.0457 0.0454
Schistosoma mansoni neuropeptide receptor 0.0028 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus multilocularis chromobox protein 1 0.0069 0.0412 0.0408
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0117 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus c-Jun N-terminal kinases 0.0239 0.1629 0.1626
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0315 0.1054
Schistosoma mansoni ferritin 0.0025 0.0098 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0337 0.0333
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0121 0.0786 0.0782
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0117 0.0337
Plasmodium falciparum metacaspase-like protein 0.0046 0.0246 0.4375
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0308 0.2124 0.2124
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0043 1
Mycobacterium tuberculosis Conserved protein 0.019 0.1282 0.1481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Trypanosoma brucei metacaspase MCA2 0.0046 0.0246 0.1893
Schistosoma mansoni adenoreceptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0088 0.0552 0.1858
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0086 0.064
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0153 0.0149
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0117 0.0117
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0153 0.0505
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0117 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0117 0.0117
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0153 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.064
Echinococcus granulosus cysteine protease 0.0017 0.0039 0.0035
Echinococcus multilocularis cathepsin L 0.0017 0.0039 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.1282 0.1481
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni opsin-like receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) fibroinase 0.0033 0.0153 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus multilocularis caspase 8 0.0046 0.0246 0.0242
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.1282 1
Schistosoma mansoni ferritin 0.0025 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0433 0.0433
Echinococcus multilocularis tumor protein p63 0.0692 0.4879 0.4877
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0117 0.0113
Schistosoma mansoni amine GPCR 0.0028 0.0117 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0743 0.5782
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.1282 0.1481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0103
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0117 0.0113
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0117 0.0113
Onchocerca volvulus 0.0033 0.0153 0.0443
Schistosoma mansoni amine GPCR 0.0028 0.0117 0.0117
Brugia malayi Pre-SET motif family protein 0.0423 0.2952 1
Brugia malayi sulfakinin receptor protein 0.0028 0.0117 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0086 0.0095
Onchocerca volvulus 0.0033 0.0153 0.0443
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.0512 1
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0552 0.0552
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0566 0.44
Onchocerca volvulus 0.0028 0.0117 0.0337
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0343 0.2656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0194 0.0566
Loa Loa (eye worm) hypothetical protein 0.0046 0.0246 0.0821
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1282 0.3796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.1282 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.1282 0.4335
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0086 0.1106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Loa Loa (eye worm) cysteine protease 0.0033 0.0153 0.0505
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0133
Onchocerca volvulus 0.0028 0.0117 0.0337
Onchocerca volvulus 0.0028 0.0117 0.0337
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.1282 0.1481
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0117 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0117 0.0113
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0122 0.0118
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0086 0.1106
Brugia malayi jmjC domain containing protein 0.0093 0.0586 0.1986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Leishmania major cathepsin L-like protease 0.0033 0.0153 0.1166
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0117 0.0397
Schistosoma mansoni amine GPCR 0.0028 0.0117 0.0117
Brugia malayi Dopamine receptor protein 1 0.0028 0.0117 0.0397
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0117 0.0385
Onchocerca volvulus 0.0028 0.0117 0.0337
Echinococcus granulosus peregrin 0.0036 0.0176 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0566 0.44
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0117 0.0113
Echinococcus granulosus caspase 8 0.0046 0.0246 0.0242
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0343 0.034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0043 0.0307
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0117 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0153 0.1166
Schistosoma mansoni hypothetical protein 0.0043 0.0223 0.0223
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0117 0.0117
Mycobacterium tuberculosis Conserved protein 0.019 0.1282 0.1481
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Onchocerca volvulus 0.0028 0.0117 0.0337
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0643 0.0643
Schistosoma mansoni tar DNA-binding protein 0.0386 0.269 0.269
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0075 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Schistosoma mansoni biogenic amine receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0117 0.0385
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0117 0.0113
Echinococcus granulosus caspase 0.0121 0.0786 0.0782
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0122 0.0922
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0117 0.0113
Mycobacterium ulcerans hypothetical protein 0.019 0.1282 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0133
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0153 0.0149
Onchocerca volvulus 0.0022 0.0075 0.0211
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0246 0.0832
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0117 0.0113
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0308 0.2124 0.2121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.04
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0246 0.1666
Leishmania major cathepsin L-like protease 0.0033 0.0153 0.1166
Brugia malayi jmjC domain containing protein 0.0034 0.0165 0.0557
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.0512 0.6878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Schistosoma mansoni caspase-3 (C14 family) 0.0121 0.0786 0.0786
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0122 0.0667
Brugia malayi larval opioid receptor 0.0028 0.0117 0.0397
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1282 0.3796
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0086 0.064
Onchocerca volvulus 0.0101 0.0643 0.19
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0353 0.0353
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0165 0.0165
Echinococcus granulosus histone acetyltransferase KAT2B 0.0299 0.2062 0.2059
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0122 0.0118
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0353 0.2729
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0086 0.064
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0117 0.0117
Schistosoma mansoni inositol monophosphatase 0.0115 0.0743 0.0743
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0586 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0194 0.0566
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0343 0.1163
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0103
Entamoeba histolytica cysteine protease, putative 0.0033 0.0153 0.2016
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Brugia malayi chromobox protein homolog 3 0.0039 0.0194 0.0659
Onchocerca volvulus 0.0033 0.0153 0.0443
Echinococcus multilocularis microtubule associated protein 2 0.1405 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0246 0.1893
Loa Loa (eye worm) inositol-1 0.0115 0.0743 0.2507
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0216 0.0629
Onchocerca volvulus 0.0033 0.0153 0.0443
Schistosoma mansoni hypothetical protein 0.0028 0.0117 0.0117
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis cysteine protease 0.0033 0.0153 0.0149
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0277
Schistosoma mansoni apoferritin-2 0.0025 0.0098 0.0098
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0121 0.0786 0.0782
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0743 0.5782
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0117 0.0397
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0117 0.0385
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0239 0.1629 0.5512
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Treponema pallidum bacterioferrin (TpF1) 0.0025 0.0098 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0216 0.0629
Onchocerca volvulus 0.0028 0.0117 0.0337
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0086 0.064
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0004 0.0004
Echinococcus granulosus chromobox protein 1 0.0069 0.0412 0.0408
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.064
Mycobacterium leprae Probable lipase LipE 0.019 0.1282 1
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0039 0.0272
Onchocerca volvulus 0.0072 0.0433 0.1276
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0117 0.0385
Brugia malayi RNA recognition motif domain containing protein 0.0386 0.269 0.9111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0133
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0449 0.0449
Loa Loa (eye worm) acetyltransferase 0.0308 0.2124 0.7192
Echinococcus granulosus g protein coupled receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.0268 0.0895
Brugia malayi beta-lactamase family protein 0.019 0.1282 0.4343
Onchocerca volvulus 0.0481 0.3372 1
Trypanosoma brucei hypothetical protein, conserved 0.019 0.1282 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) RNA binding protein 0.0386 0.269 0.9109
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0343 0.0343
Schistosoma mansoni neuropeptide receptor 0.0028 0.0117 0.0117
Plasmodium vivax SET domain protein, putative 0.0061 0.0353 0.2525
Loa Loa (eye worm) ctsf protein 0.0033 0.0153 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0117 0.0113
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0412 0.1212
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0117 0.0117
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1215 0.8637 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0353 0.0349
Leishmania major cathepsin L-like protease 0.0033 0.0153 0.1166
Echinococcus granulosus allatostatin A receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Plasmodium falciparum phd finger protein, putative 0.0028 0.0122 0.1752
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0246 0.1893
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0743 0.0739
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0964 0.0964
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0964 0.0964
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0153 0.0149
Onchocerca volvulus 0.019 0.1282 0.3796
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0117 0.0113
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0743 1
Schistosoma mansoni ferritin 0.0025 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus hypothetical protein 0.0028 0.0117 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Brugia malayi PHD-finger family protein 0.0028 0.0122 0.0412
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Mycobacterium ulcerans lipase LipD 0.019 0.1282 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0886 0.0883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0039 0.0131
Trypanosoma brucei metacaspase MCA3 0.0046 0.0246 0.1893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Onchocerca volvulus 0.0033 0.0153 0.0443
Trichomonas vaginalis ferritin, putative 0.0025 0.0098 0.0279
Onchocerca volvulus 0.0043 0.0223 0.0652
Onchocerca volvulus 0.0028 0.0117 0.0337
Onchocerca volvulus Alhambra homolog 0.0028 0.0122 0.035
Echinococcus granulosus fmrfamide receptor 0.0028 0.0117 0.0113
Leishmania major cathepsin L-like protease 0.0125 0.0815 0.6344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0153 0.0149
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Onchocerca volvulus 0.0028 0.0117 0.0337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Echinococcus granulosus expressed protein 0.0025 0.0098 0.0094
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0246 0.1893
Echinococcus multilocularis caspase 2 0.0088 0.0552 0.0548
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0886 0.0883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0075 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1282 0.3796
Onchocerca volvulus 0.019 0.1282 0.3796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0153 0.2016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0386 0.269 0.9109
Leishmania major cathepsin L-like protease 0.0125 0.0815 0.6344
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0117 0.0113
Trypanosoma cruzi major cysteine proteinase, putative 0.0098 0.0623 0.4842
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0277
Echinococcus granulosus ferritin 0.0025 0.0098 0.0094
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0117 0.0113
Leishmania major cathepsin L-like protease 0.0125 0.0815 0.6344
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0117 0.0113
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Trichomonas vaginalis set domain proteins, putative 0.0481 0.3372 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Echinococcus granulosus cathepsin l1 0.0033 0.0153 0.0149
Echinococcus multilocularis expressed protein 0.0025 0.0098 0.0094
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0025 0.0098 0.0736
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0552 0.1627
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.1282 0.1279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Echinococcus granulosus chromobox protein 1 0.0069 0.0412 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.0512 1
Echinococcus granulosus neuropeptide receptor 0.0028 0.0117 0.0113
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0098 0.0736
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0964 0.096
Onchocerca volvulus 0.003 0.0135 0.0388
Schistosoma mansoni amine GPCR 0.0028 0.0117 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0343 0.2656
Schistosoma mansoni hypothetical protein 0.0028 0.0122 0.0122
Mycobacterium leprae conserved hypothetical protein 0.019 0.1282 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Brugia malayi acetyltransferase, GNAT family protein 0.0308 0.2124 0.7195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0039 0.0272
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0086 0.1106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0039 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1282 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0743 0.5782
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0117 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0246 0.1893
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0246 0.0246
Echinococcus granulosus caspase 2 0.0088 0.0552 0.0548
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0743 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0117 0.0117
Brugia malayi cathepsin L-like precursor 0.0022 0.0075 0.0254
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0117 0.0113
Onchocerca volvulus 0.019 0.1282 0.3796
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0117 0.0117
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Echinococcus granulosus jumonji domain containing protein 0.004 0.0202 0.0198
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0117 0.0113
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0117 0.0113
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0117 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Mycobacterium tuberculosis Probable hydrolase 0.019 0.1282 0.1481
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0117 0.0113
Toxoplasma gondii cathepsin CPL 0.0033 0.0153 0.1166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0122 0.04
Leishmania major cathepsin L-like protease 0.0033 0.0153 0.1166
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Schistosoma mansoni biogenic amine receptor 0.0028 0.0117 0.0117
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0743 0.5782
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0117 0.0113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0117 0.0385
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0117 0.0397
Loa Loa (eye worm) beta-lactamase 0.019 0.1282 0.4335
Leishmania major cathepsin L-like protease 0.0033 0.0153 0.1166
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0122 0.0922
Trypanosoma cruzi metacaspase, putative 0.0046 0.0246 0.1893
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0353 0.0349
Brugia malayi beta-lactamase 0.019 0.1282 0.4343
Schistosoma mansoni hypothetical protein 0.0028 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0117 0.0113
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0153 0.2412
Echinococcus granulosus g protein coupled receptor 0.0028 0.0117 0.0113
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0165 0.0545
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0117 0.0113
Echinococcus granulosus g protein coupled receptor 0.0028 0.0117 0.0113
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0153 0.0517
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0744
Brugia malayi Cathepsin L-like precursor 0.0022 0.0075 0.0254
Echinococcus multilocularis ferritin 0.0025 0.0098 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0117 0.0113
Schistosoma mansoni hypothetical protein 0.0135 0.0886 0.0886
Brugia malayi Bromodomain containing protein 0.0036 0.0176 0.0595
Brugia malayi Dopamine receptor 0.0028 0.0117 0.0397
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0039 0.0039
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0153 0.0443
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.029
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis chromobox protein 1 0.0069 0.0412 0.0408
Brugia malayi TAR-binding protein 0.0386 0.269 0.9111
Schistosoma mansoni hypothetical protein 0.0028 0.0117 0.0117
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Mycobacterium ulcerans beta-lactamase 0.019 0.1282 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0202 0.0198
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0098 0.0109
Echinococcus multilocularis caspase 3 0.0075 0.0457 0.0454
Leishmania major hypothetical protein, conserved 0.019 0.1282 1
Echinococcus granulosus cathepsin l1 0.0022 0.0075 0.0071
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0117 0.0117
Onchocerca volvulus 0.0028 0.0117 0.0337
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0117 0.0385
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0815 0.6344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Schistosoma mansoni tar DNA-binding protein 0.0386 0.269 0.269
Schistosoma mansoni tar DNA-binding protein 0.0386 0.269 0.269
Schistosoma mansoni neuropeptide receptor 0.0028 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Brugia malayi neuropeptide F receptor 0.0028 0.0117 0.0397
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0566 0.4243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0086 0.0095
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0039 0.0039
Trypanosoma cruzi metacaspase, putative 0.0046 0.0246 0.1893
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0277
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0339 0.1137
Brugia malayi Cathepsin L-like precursor 0.0033 0.0153 0.0517
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0037
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0117 0.0397
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0039 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0153 0.0443
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Echinococcus granulosus sex peptide receptor 0.0028 0.0117 0.0113
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1282 0.3796
Schistosoma mansoni biogenic amine receptor 0.0028 0.0117 0.0117
Echinococcus granulosus tar DNA binding protein 0.0386 0.269 0.2687
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0117 0.0113
Echinococcus granulosus somatostatin receptor 0.0028 0.0117 0.0113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0743 0.2195
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0117 0.0397
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0153 0.2016
Toxoplasma gondii ABC1 family protein 0.019 0.1282 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0117 0.0113
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.1282 0.1481
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0353 0.0353
Brugia malayi Serotonin receptor 0.0028 0.0117 0.0397
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0246 0.1893
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0114 0.0326
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0743 0.2195
Trypanosoma cruzi cruzipain precursor, putative 0.0125 0.0815 0.6344
Schistosoma mansoni histamine h1 receptor 0.0028 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0246 0.0719
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0043 0.0036
Onchocerca volvulus 0.0028 0.0117 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0153 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0815 0.6344
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.076 0.2565
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.064
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Loa Loa (eye worm) hypothetical protein 0.019 0.1282 0.4335
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1282 0.3796
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0385
Mycobacterium ulcerans hypothetical protein 0.0023 0.0086 0.064
Brugia malayi Dopamine receptor protein 2 0.0028 0.0117 0.0397
Schistosoma mansoni tar DNA-binding protein 0.0386 0.269 0.269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0039 0.0272
Onchocerca volvulus 0.0028 0.0117 0.0337
Onchocerca volvulus 0.0028 0.0117 0.0337
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0117 0.0113
Echinococcus multilocularis serotonin receptor 0.0028 0.0117 0.0113
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0117 0.0113
Schistosoma mansoni opsin-like receptor 0.0028 0.0117 0.0117
Brugia malayi GnHR receptor homolog 0.0028 0.0117 0.0397
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0117 0.0113
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0815 0.6344
Plasmodium falciparum metacaspase 1 0.0046 0.0246 0.4375
Schistosoma mansoni microtubule-associated protein tau 0.1405 1 1
Trypanosoma brucei Metacaspase-4 0.0046 0.0246 0.1893
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0743 0.2195
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0133
Brugia malayi RNA binding protein 0.0386 0.269 0.9111
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0122 0.0122
Onchocerca volvulus 0.0028 0.0117 0.0337
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0505
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.1282 0.4343
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0471
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0117 0.0397
Echinococcus granulosus neuropeptide receptor 0.0028 0.0117 0.0113
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0117 0.0113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0028 0.0117 0.0117
Brugia malayi hypothetical protein 0.0028 0.0117 0.0397
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0153 0.1166
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0246 0.0719
Echinococcus multilocularis serotonin receptor 0.0028 0.0117 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0075 0.0075
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0117 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0037
Echinococcus granulosus serotonin receptor 0.0028 0.0117 0.0113

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 154.1 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 as LDH reporter activity ChEMBL. 18562202
IC50 (functional) = 776.2 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity ChEMBL. 18562202
IC50 (ADMET) = 2614 nM Cytotoxicity against human K562 cells by MTT assay ChEMBL. 18562202
Ratio IC50 (functional) = 0.2 Relative selectivity against Plasmodium falciparum D10 as IC50 ratio compared to chloroquine ChEMBL. 18562202
Ratio IC50 (functional) = 0.8 Relative selectivity against Plasmodium falciparum W2 as IC50 ratio compared to chloroquine ChEMBL. 18562202

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18562202
Plasmodium falciparum ChEMBL23 18562202

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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