Detailed information for compound 996599

Basic information

Technical information
  • TDR Targets ID: 996599
  • Name: 2-(methoxymethyl)-N-[4-(trifluoromethyl)pheny l]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazo lin-4-amine
  • MW: 478.39 | Formula: C23H16F6N4O
  • H donors: 1 H acceptors: 3 LogP: 5.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1nc(Nc2ccc(cc2)C(F)(F)F)c2c(n1)cc(cc2)c1ncccc1C(F)(F)F
  • InChi: 1S/C23H16F6N4O/c1-34-12-19-32-18-11-13(20-17(23(27,28)29)3-2-10-30-20)4-9-16(18)21(33-19)31-15-7-5-14(6-8-15)22(24,25)26/h2-11H,12H2,1H3,(H,31,32,33)
  • InChiKey: AUMMEWJHZYQLQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(methoxymethyl)-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)-2-pyridyl]quinazolin-4-amine
  • 2-(methoxymethyl)-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)-2-pyridyl]-4-quinazolinamine
  • [2-(methoxymethyl)-7-[3-(trifluoromethyl)-2-pyridyl]quinazolin-4-yl]-[4-(trifluoromethyl)phenyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References
Rattus norvegicus Vanilloid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0241 0.0745
Echinococcus granulosus voltage gated potassium channel 0.0008 0.0052 0.0052
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.0013 0.0013
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0241 0.0745
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0008 0.0052 0.1075
Onchocerca volvulus 0.0005 0.0013 0.0039
Loa Loa (eye worm) ion channel NompC 0.0008 0.0052 0.016
Echinococcus granulosus neuropeptide receptor A26 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0084 0.0259
Schistosoma mansoni neuropeptide receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0008 0.0052 0.0052
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.0013 0.0013
Schistosoma mansoni adenoreceptor 0.0005 0.0013 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.01 0.0311
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0008 0.0052 0.016
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0008 0.0052 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0052 0.0703
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0052 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0005 0.0013 0.0013
Schistosoma mansoni 60S ribosomal protein L21 0.0008 0.0052 0.0052
Loa Loa (eye worm) voltage-gated potassium channel 0.0008 0.0052 0.016
Schistosoma mansoni neuropeptide receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0052 0.016
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0241 0.0745
Echinococcus granulosus TRP transient receptor potential channel 0.0008 0.0052 0.0052
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0008 0.0052 0.1075
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Giardia lamblia Hypothetical protein 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) voltage-gated calcium channel 0.0008 0.0052 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Echinococcus multilocularis G-protein coupled receptor, putative 0.0005 0.0013 0.0013
Echinococcus multilocularis shaker cognate 0.0008 0.0052 0.0052
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.0013 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.0005 0.0013 0.0013
Brugia malayi GnHR receptor homolog 0.0005 0.0013 0.0041
Echinococcus multilocularis potassium large conductance calcium activated 0.0008 0.0052 0.0052
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.0013 0.0041
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0241 0.0241
Onchocerca volvulus 0.0005 0.0013 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.0013 0.0041
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus dnaJ subfamily B 0.0431 0.5904 0.5904
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Schistosoma mansoni nuclear hormone receptor 0.001 0.0084 0.0084
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0008 0.0052 0.016
Echinococcus multilocularis voltage dependent calcium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) ryanodine receptor 0.0008 0.0052 0.016
Brugia malayi larval opioid receptor 0.0005 0.0013 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0084 0.0084
Brugia malayi hypothetical protein 0.001 0.0084 0.0259
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0032 0.0386 0.0386
Echinococcus granulosus allatostatin A receptor 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-dependent calcium channel 0.0008 0.0052 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0052 0.0052
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0084 0.0259
Onchocerca volvulus 0.0005 0.0013 0.0039
Schistosoma mansoni myosin xvIII 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0048 0.0048
Brugia malayi Dopamine receptor protein 1 0.0005 0.0013 0.0041
Onchocerca volvulus 0.0005 0.0013 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0013 0.0013
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0008 0.0052 0.0052
Brugia malayi Inositol-1 0.0039 0.0482 0.1493
Onchocerca volvulus 0.001 0.0084 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0008 0.0052 0.016
Brugia malayi Dopamine receptor protein 2 0.0005 0.0013 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0241 0.0745
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis serotonin receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis G protein coupled receptor 139 0.0005 0.0013 0.0013
Trypanosoma brucei trans-sialidase, putative 0.003 0.0364 0.7556
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0008 0.0052 0.1075
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0052 0.0052
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Brugia malayi cation channel family protein 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0052 0.0703
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0241 0.0241
Echinococcus granulosus neuropeptide s receptor 0.0005 0.0013 0.0013
Brugia malayi hypothetical protein 0.0011 0.01 0.0311
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0084 0.0259
Echinococcus multilocularis two pore calcium channel protein 1 0.0008 0.0052 0.0052
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.01 0.0311
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0084 0.0247
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0084 0.0084
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0241 0.0241
Brugia malayi nuclear hormone receptor 0.0237 0.3228 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.0013 0.0041
Schistosoma mansoni transient receptor potential channel 0.0008 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Trypanosoma brucei trans-sialidase, putative 0.003 0.0364 0.7556
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0052 0.0052
Trypanosoma brucei trans-sialidase, putative 0.003 0.0364 0.7556
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0241 0.0745
Echinococcus granulosus voltage gated potassium channel 0.0008 0.0052 0.0052
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0048 0.0048
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Trypanosoma brucei trans-sialidase 0.003 0.0364 0.7556
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0005 0.0013 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0241 0.0745
Onchocerca volvulus Neuropeptide F receptor homolog 0.0005 0.0013 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.0013 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0052 0.0052
Schistosoma mansoni neuropeptide receptor 0.0005 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0039 0.0482 0.0482
Brugia malayi hypothetical protein 0.0008 0.0052 0.016
Brugia malayi hypothetical protein 0.0011 0.01 0.0311
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0008 0.0052 0.0052
Echinococcus multilocularis voltage gated potassium channel 0.0008 0.0052 0.0052
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0008 0.0052 0.016
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0052 0.0052
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0482 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0008 0.0052 0.0052
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0052 0.0052
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0084 0.0084
Brugia malayi neuropeptide F receptor 0.0005 0.0013 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0311
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0052 0.0703
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7555
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0052 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0013 0.0013
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0052 0.0703
Onchocerca volvulus 0.0005 0.0013 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Onchocerca volvulus 0.0005 0.0013 0.0039
Onchocerca volvulus 0.0008 0.0052 0.0153
Echinococcus granulosus hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0482 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0005 0.0013 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0241 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0241 0.0745
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis somatostatin receptor 0.0005 0.0013 0.0013
Echinococcus granulosus potassium large conductance calcium activated 0.0008 0.0052 0.0052
Echinococcus multilocularis voltage gated potassium channel 0.0008 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0241 0.0745
Onchocerca volvulus 0.0005 0.0013 0.0039
Onchocerca volvulus 0.0005 0.0013 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.0013 0.0013
Onchocerca volvulus 0.0005 0.0013 0.0039
Schistosoma mansoni amine GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0005 0.0013 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0482 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0084 0.0084
Onchocerca volvulus 0.0005 0.0013 0.0039
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0008 0.0052 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Echinococcus multilocularis g-protein coupled receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.0013 0.0041
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0008 0.0052 0.016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0241 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0008 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.001 0.0084 0.0259
Echinococcus multilocularis neuropeptide FF receptor 2 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0084 0.0247
Echinococcus multilocularis dro:myosuppressin receptor 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0241 0.0241
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Toxoplasma gondii hypothetical protein 0.0008 0.0052 0.0703
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0084 0.0084
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0084 0.0084
Schistosoma mansoni nuclear receptor 0.001 0.0084 0.0084
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0008 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0241 0.0745
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0013 0.0013
Brugia malayi ecdysteroid receptor 0.0021 0.0241 0.0745
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) calcium channel 0.0008 0.0052 0.016
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0425 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0241 0.0241
Echinococcus granulosus voltage gated hydrogen channel 1 0.0008 0.0052 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0362 0.0362
Schistosoma mansoni cpg binding protein 0.0032 0.0386 0.0386
Brugia malayi steroid hormone receptor 0.0021 0.0241 0.0745
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0008 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Schistosoma mansoni ryanodine receptor related 0.0008 0.0052 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Echinococcus multilocularis short transient receptor potential channel 6 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0241 0.0241
Schistosoma mansoni coup transcription factor 0.0021 0.0241 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0052 0.0052
Brugia malayi Serotonin receptor 0.0005 0.0013 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Schistosoma mansoni vesicular amine transporter 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0084 0.0084
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0008 0.0052 0.0153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.01 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Leishmania major hypothetical protein, unknown function 0.0008 0.0052 0.1075
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0482 0.0482
Echinococcus granulosus serotonin receptor 0.0005 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0008 0.0052 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.0013 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0241 0.0241
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0052 0.0052
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0008 0.0052 0.016
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0008 0.0052 0.0052
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.01 0.01
Echinococcus granulosus short transient receptor potential channel 6 0.0008 0.0052 0.0052
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7556
Brugia malayi CXXC zinc finger family protein 0.003 0.0362 0.1122
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Onchocerca volvulus 0.0005 0.0013 0.0039
Onchocerca volvulus 0.0005 0.0013 0.0039
Brugia malayi nuclear receptor NHR-67 0.001 0.0084 0.0259
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi putative neuropeptide receptor 0.0005 0.0013 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.01 0.0311
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0005 0.0013 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.0013 0.0013
Brugia malayi RE15519p 0.0005 0.0013 0.0041
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0052 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi Serotonin receptor 0.0005 0.0013 0.0041
Trypanosoma brucei trans-sialidase, putative 0.003 0.0364 0.7556
Echinococcus multilocularis sodium leak channel non selective protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0013 0.0041
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0005 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0008 0.0052 0.0052
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.5904 0.5904
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis neuropeptide receptor 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0008 0.0052 0.016
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7555
Loa Loa (eye worm) hypothetical protein 0.0227 0.3088 0.9566
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis two pore calcium channel protein 2 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Onchocerca volvulus 0.0005 0.0013 0.0039
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0008 0.0052 0.1075
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Schistosoma mansoni hypothetical protein 0.0005 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Brugia malayi Transient-receptor-potential like protein 0.0008 0.0052 0.016
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.0013 0.0013
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0084 0.0084
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0013 0.0041
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Schistosoma mansoni opsin-like receptor 0.0005 0.0013 0.0013
Onchocerca volvulus 0.0005 0.0013 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0052 0.0052
Echinococcus granulosus two pore calcium channel protein 2 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0311
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus g protein coupled receptor 0.0005 0.0013 0.0013
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.0013 0.0013
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0084 0.0259
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.0013 0.0013
Onchocerca volvulus 0.0005 0.0013 0.0039
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7556
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0005 0.0013 0.0013
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.0013 0.0013
Brugia malayi ORL1-like opioid receptor 0.0005 0.0013 0.0041
Schistosoma mansoni voltage-gated cation channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) inositol-1 0.0039 0.0482 0.1493
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0362 0.1122
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0008 0.0052 0.016
Echinococcus multilocularis fmrfamide receptor 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0241 0.0745
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0052 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Onchocerca volvulus 0.0005 0.0013 0.0039
Echinococcus granulosus orexin receptor type 2 0.0005 0.0013 0.0013
Echinococcus multilocularis serotonin receptor 0.0005 0.0013 0.0013
Brugia malayi nuclear receptor RXR 0.001 0.0084 0.0259
Trypanosoma brucei trans-sialidase, putative 0.003 0.0364 0.7556
Echinococcus granulosus sodium channel protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.0013 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0052 0.1075
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0052 0.0052
Schistosoma mansoni amine GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0241 0.0745
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.01 0.01
Brugia malayi conserved hypotetical protein 0.001 0.0084 0.0259
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.0013 0.0013
Brugia malayi olfactory channel protein osm-9 0.0008 0.0056 0.0173
Brugia malayi G-protein coupled receptor 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0241 0.0745
Brugia malayi neuropeptide F receptor 0.0005 0.0013 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0241 0.0241
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0008 0.0052 0.016
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0241 0.0745
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.1075
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0241 0.0241
Brugia malayi Nuclear hormone receptor E75 0.001 0.0084 0.0259
Echinococcus multilocularis transfer RNA-Gly 0.0008 0.0052 0.0052
Echinococcus granulosus fmrfamide receptor 0.0005 0.0013 0.0013
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus granulosus tachykinin peptides receptor 99D 0.0005 0.0013 0.0013
Echinococcus granulosus voltage dependent calcium channel 0.0008 0.0052 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0482 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0084 0.0084
Echinococcus granulosus neuropeptide receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0005 0.0013 0.0013
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0073 0.0226
Brugia malayi G protein-coupled receptor 0.0005 0.0013 0.0041
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0482 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0482 0.0482
Trichomonas vaginalis helicase, putative 0.0007 0.0038 0.0797
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0052 0.0052
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.0013 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0052 0.0052
Schistosoma mansoni biogenic amine receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage dependent calcium channel 0.0008 0.0052 0.0052
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0052 0.0052
Brugia malayi G-protein coupled receptor 0.0005 0.0013 0.0041
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0052 0.0052
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0052 0.0052
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0008 0.0052 0.0153
Echinococcus granulosus neuropeptide receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0056 0.0056
Loa Loa (eye worm) voltage-gated potassium channel 0.0008 0.0052 0.016
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0084 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0241 0.0241
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.0013 0.0041
Echinococcus multilocularis calcium activated potassium channel 0.0008 0.0052 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Brugia malayi nuclear hormone receptor 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0241 0.0745
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0241 0.0241
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0005 0.0013 0.0013
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0008 0.0052 0.016
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0008 0.0052 0.0052
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.0013 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0241 0.0241
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0241 0.0711
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0013 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0052 0.0052
Schistosoma mansoni opsin-like receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Brugia malayi hypothetical protein 0.001 0.0084 0.0259
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis neuropeptide receptor 0.0005 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0073
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0052 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0831 0.0831
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0241 0.0241
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0052 0.0703
Schistosoma mansoni neuropeptide receptor 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0005 0.0013 0.0041
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0482 1
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0241 0.0745
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0084 0.0084
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus short transient receptor potential channel 6 0.0008 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi ion channel NompC 0.0008 0.0052 0.016
Echinococcus granulosus transient receptor potential gamma protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis orexin receptor type 2 0.0005 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0052 0.0052
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.0013 0.0013
Schistosoma mansoni two-pore calcium channel 0.0008 0.0052 0.0052
Schistosoma mansoni calcium-activated potassium channel 0.0008 0.0052 0.0052
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0482 1
Brugia malayi voltage-dependent calcium channel 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0241 0.0241
Onchocerca volvulus 0.003 0.0362 0.107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0241 0.0745
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Schistosoma mansoni histamine h1 receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.0726 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0071 0.0221
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0241 0.0241
Echinococcus multilocularis allatostatin A receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus ryanodine receptor 44f 0.0008 0.0052 0.0052
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0052 0.0052
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.0013 0.0041
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.0013 0.0041
Echinococcus granulosus voltage dependent calcium channel 0.0008 0.0052 0.0052
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0008 0.0052 0.0052
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0052 0.0052
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0052 0.0052
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0008 0.0052 0.0052
Brugia malayi hypothetical protein 0.0005 0.0013 0.0041
Onchocerca volvulus 0.0021 0.0241 0.0711
Schistosoma mansoni microtubule-associated protein tau 0.0726 1 1
Onchocerca volvulus 0.001 0.0084 0.0247
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Echinococcus granulosus G protein coupled receptor 139 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0052 0.0052
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Brugia malayi tailless protein 0.001 0.0084 0.0259
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0052 0.0052
Brugia malayi nuclear receptor RXR 0.0011 0.01 0.0311
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0008 0.0052 0.0052
Echinococcus granulosus g protein coupled receptor 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0008 0.0052 0.016
Echinococcus granulosus cpg binding protein 0.0032 0.0386 0.0386
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0038 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0013 0.0013
Echinococcus granulosus somatostatin receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0008 0.0052 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0241 0.0745
Toxoplasma gondii hypothetical protein 0.0008 0.0052 0.0703
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0241 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797
Onchocerca volvulus 0.0005 0.0013 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis cpg binding protein 0.0032 0.0386 0.0386
Brugia malayi AKH receptor 0.0005 0.0013 0.0041
Schistosoma mansoni nuclear receptor 0.001 0.0084 0.0084
Echinococcus granulosus calcium activated potassium channel 0.0008 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0008 0.0052 0.0052
Brugia malayi Dopamine receptor 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Brugia malayi cation channel family protein 0.0008 0.0052 0.016
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0482 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0084 0.0259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0241 0.0241
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0052 0.0052
Schistosoma mansoni opsin-like receptor 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 4 0.0008 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0431 0.5904 0.5904
Schistosoma mansoni zinc finger protein 0.001 0.0084 0.0084
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.0013 0.0013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0005 0.0013 0.0013
Brugia malayi ecdysone receptor 0.001 0.0084 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0013 0.0013
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7555
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0241 0.0241
Echinococcus multilocularis short transient receptor potential channel 6 0.0008 0.0056 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Brugia malayi nuclear receptor NHR-88 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0008 0.0056 0.0173
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0008 0.0052 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.0013 0.0041
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0038 0.0797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0084 0.0084
Echinococcus granulosus neuropeptide FF receptor 2 0.0005 0.0013 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0241 0.0241
Schistosoma mansoni biogenic amine receptor 0.0005 0.0013 0.0013
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0052 0.0052
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0084 0.0259
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0482 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0241 0.0745
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0249 0.3385 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0482 0.6542
Schistosoma mansoni amine GPCR 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0736 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0241 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0241 0.0745
Loa Loa (eye worm) DR-78 0.001 0.0084 0.0259
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0084 0.0084
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0013 0.0013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.0013 0.0041
Echinococcus granulosus two pore calcium channel protein 1 0.0008 0.0052 0.0052
Echinococcus multilocularis transient receptor potential gamma protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) voltage-dependent calcium channel 0.0008 0.0052 0.016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0241 0.0241
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0052 0.0052
Brugia malayi sulfakinin receptor protein 0.0005 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0241 0.0241
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0241 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 0.0008 0.0052 0.0052
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0038 0.0797
Echinococcus granulosus g-protein coupled receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis sodium channel protein 0.0008 0.0052 0.0052
Echinococcus multilocularis sex peptide receptor 0.0005 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus dro:myosuppressin receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0241 0.0241
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0008 0.0052 0.0052
Schistosoma mansoni transient receptor potential channel 0.0008 0.0052 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0052 0.0052
Echinococcus granulosus shaker cognate 0.0008 0.0052 0.0052
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0008 0.0052 0.1075
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0052 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus hypothetical protein 0.0008 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0052 0.1075
Schistosoma mansoni amine GPCR 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0008 0.0052 0.0052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0241 0.0241
Trypanosoma cruzi trans-sialidase, Group I, putative 0.003 0.0364 0.7556
Schistosoma mansoni voltage-gated ion channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0052 0.0052
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0052 0.0052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0005 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor 0.001 0.0084 0.0084
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0052 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0241 0.0241
Echinococcus granulosus 7tm_1 domain containing protein 0.0005 0.0013 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Schistosoma mansoni hypothetical protein 0.0005 0.0013 0.0013
Echinococcus multilocularis ryanodine receptor 44f 0.0008 0.0052 0.0052
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0008 0.0052 0.0052
Brugia malayi Melatonin receptor type 1A 0.0005 0.0013 0.0041
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0008 0.0052 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0241 0.0711
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7556
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0482 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0052 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0241 0.0241
Echinococcus granulosus sodium leak channel non selective protein 0.0008 0.0052 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0052 0.0052
Echinococcus granulosus sex peptide receptor 0.0005 0.0013 0.0013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0311
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0013 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0745
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0008 0.0052 0.0052
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.0013 0.0041
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0084 0.0084
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0008 0.0052 0.0052
Trypanosoma cruzi trans-sialidase, putative 0.003 0.0364 0.7555
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0013 0.0013
Echinococcus granulosus g protein coupled receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0237 0.3228 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0038 0.0797

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.5 nM Antagonist activity at rat TRPV1 receptor assessed as inhibition of low pH-induced activation ChEMBL. 18662872
IC50 (functional) = 1.5 nM Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activation ChEMBL. 18662872
IC50 (binding) = 1.5 nM Inhibition of human TRPV1 ChEMBL. 20307063
Inhibition (binding) = 44 % Inhibition of human ERG potassium channel expressed in african green monkey COS7 cells at 3 uM by whole cell assay ChEMBL. 18662872
Inhibition (binding) = 44 % Inhibition of human ERG expressed in COS7 cells at 3 uM by electrophysiology assay ChEMBL. 20307063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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