Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.059 | 0.1708 |
Onchocerca volvulus | 0.0071 | 0.059 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2953 | 0.5025 |
Plasmodium vivax | hypothetical protein, conserved | 0.0071 | 0.059 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.059 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.059 | 0.1708 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.059 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.059 | 0.1708 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0185 | 0.3402 | 0.9855 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.016 | 0.0273 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.016 | 0.0464 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.059 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.059 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.059 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0.059 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.059 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0187 | 0.3452 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.059 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Loa Loa (eye worm) | RNA binding protein | 0.0187 | 0.3452 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.016 | 0.0464 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.059 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0071 | 0.059 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.059 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.059 | 0.1003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.3452 | 0.5875 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.059 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0071 | 0.059 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.016 | 0.0464 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0185 | 0.3402 | 0.9855 |
Brugia malayi | RNA binding protein | 0.0187 | 0.3452 | 1 |
Onchocerca volvulus | 0.0071 | 0.059 | 1 | |
Brugia malayi | TAR-binding protein | 0.0187 | 0.3452 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.3452 | 0.5875 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.3452 | 0.5875 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.059 | 0.1708 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.016 | 0.0464 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.059 | 0.1708 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.059 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.016 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2953 | 0.8554 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2953 | 0.5025 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.016 | 0.0464 |
Schistosoma mansoni | hypothetical protein | 0.0286 | 0.5875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.059 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.059 | 0.1708 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.059 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.059 | 0.1708 |
Echinococcus granulosus | geminin | 0.0167 | 0.2953 | 0.8554 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.059 | 0.1708 |
Echinococcus granulosus | tar DNA binding protein | 0.0187 | 0.3452 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0187 | 0.3452 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.3452 | 0.5875 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.3452 | 0.5875 |
Loa Loa (eye worm) | TAR-binding protein | 0.0187 | 0.3452 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.059 | 0.1003 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.059 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0187 | 0.3452 | 1 |
Brugia malayi | beta-lactamase | 0.0071 | 0.059 | 0.1708 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.059 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.016 | 0.0464 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32 nM | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells | ChEMBL. | 19233647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.