TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.292 | Formula: C23H17Cl2NO3
H donors: 1 H acceptors: 3 LogP: 4.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)CN1[C@@H](c2ccc(cc2)Cl)[C@H](C(=O)O)c2c(C1=O)cccc2
InChi: 1S/C23H17Cl2NO3/c24-16-9-5-14(6-10-16)13-26-21(15-7-11-17(25)12-8-15)20(23(28)29)18-3-1-2-4-19(18)22(26)27/h1-12,20-21H,13H2,(H,28,29)/t20-,21+/m1/s1
InChiKey: XIYILCWDRBCFJW-RTWAWAEBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MDM2 proto-oncogene, E3 ubiquitin protein ligase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0275	0.0685	1
Echinococcus granulosus	contactin	0.0215	0.0528	0.3233
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.049	0.1247	0.7635
Schistosoma mansoni	titin	0.0215	0.0528	0.3233
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0142	0.0336	0.2059
Onchocerca volvulus		0.0215	0.0528	0.0569
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	usherin	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Schistosoma mansoni	BC026374 protein (S09 family)	0.0024	0.0029	0.0176
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0336	0.0356
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0013	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.049	0.1247	0.7635
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0215	0.0528	0.0559
Onchocerca volvulus		0.0275	0.0685	0.0738
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0275	0.0685	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0275	0.0685	0.0726
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.049	0.1247	0.7635
Schistosoma mansoni	cell adhesion molecule	0.0215	0.0528	0.3233
Brugia malayi	Carboxylesterase family protein	0.0142	0.0336	0.0336
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0215	0.0528	0.0528
Mycobacterium ulcerans	carboxylesterase, LipT	0.0024	0.0029	0.5
Onchocerca volvulus		0.0275	0.0685	0.0738
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0215	0.0528	0.0559
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0013	0	0.5
Onchocerca volvulus		0.0215	0.0528	0.0569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.049	0.1247	0.7635
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0275	0.0685	0.4196
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0215	0.0528	0.0559
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	hypothetical protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus multilocularis	Fibronectin, type III	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	EG95	0.0215	0.0528	0.3233
Echinococcus multilocularis	Netrin receptor DCC	0.0215	0.0528	0.3233
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0013	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Onchocerca volvulus		0.0215	0.0528	0.0569
Onchocerca volvulus		0.0024	0.0029	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Plasmodium vivax	hypothetical protein, conserved	0.0013	0	0.5
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0275	0.0685	0.0726
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.049	0.1247	0.7635
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus multilocularis	acetylcholinesterase	0.0142	0.0336	0.2059
Onchocerca volvulus		0.0275	0.0685	0.0738
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.049	0.1247	0.7635
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0275	0.0685	0.4196
Schistosoma mansoni	hemicentin	0.0215	0.0528	0.3233
Brugia malayi	Carboxylesterase family protein	0.0024	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0638	0.1633	1
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0275	0.0685	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0638	0.1633	0.1633
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Onchocerca volvulus		0.0215	0.0528	0.0569
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Brugia malayi	Carboxylesterase family protein	0.0024	0.0029	0.0029
Loa Loa (eye worm)	lethal protein 805	0.0215	0.0528	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	roundabout 2	0.0215	0.0528	0.3233
Echinococcus granulosus	carboxylesterase 5A	0.0142	0.0336	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0275	0.0685	0.4196
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0275	0.0685	0.0726
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0215	0.0528	0.3233
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0275	0.0685	0.4196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0024	0.0029	0.0176
Brugia malayi	Lethal protein 805	0.0215	0.0528	0.0528
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0215	0.0528	0.0528
Brugia malayi	Carboxylesterase family protein	0.0024	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	anosmin 1	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.049	0.1247	0.7635
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Loa Loa (eye worm)	carboxylesterase	0.0024	0.0029	0.003
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	acetylcholinesterase	0.0142	0.0336	0.2059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Loa Loa (eye worm)	myotactin form A	0.0215	0.0528	0.0559
Onchocerca volvulus		0.0275	0.0685	0.0738
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Schistosoma mansoni	acetylcholinesterase	0.0024	0.0029	0.0176
Schistosoma mansoni	protein tyrosine phosphatase	0.0275	0.0685	0.4196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0215	0.0528	0.3233
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0275	0.0685	1
Echinococcus multilocularis	neuroglian	0.0215	0.0528	0.3233
Schistosoma mansoni	titin	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0638	0.1633	1
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0215	0.0528	0.3233
Echinococcus granulosus	neuroligin	0.0024	0.0029	0.0176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Echinococcus granulosus	BC026374 protein S09 family	0.0024	0.0029	0.0176
Echinococcus multilocularis	usherin	0.0215	0.0528	0.3233
Schistosoma mansoni	hypothetical protein	0.0215	0.0528	0.3233
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0275	0.0685	0.4196
Loa Loa (eye worm)	acetylcholinesterase 1	0.0142	0.0336	0.0356
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.049	0.1247	0.7635
Echinococcus multilocularis	carboxylesterase 5A	0.0142	0.0336	0.2059
Echinococcus granulosus	anosmin 1	0.0215	0.0528	0.3233
Schistosoma mansoni	factor for adipocyte differentiation	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0024	0.0029	0.0031
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.0029	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	carboxylesterase	0.0142	0.0336	0.0356
Schistosoma mansoni	hypothetical protein	0.0215	0.0528	0.3233
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.049	0.1247	0.7635
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	roundabout 2	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0275	0.0685	0.4196
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0638	0.1633	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus multilocularis	Netrin receptor DCC	0.0215	0.0528	0.3233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Onchocerca volvulus		0.0275	0.0685	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Giardia lamblia	Protein tyrosine phosphatase	0.0275	0.0685	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.049	0.1247	0.1321
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0013	0	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0215	0.0528	0.0528
Echinococcus granulosus	Netrin receptor DCC	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0024	0.0029	0.0031
Onchocerca volvulus		0.0024	0.0029	0.0031
Brugia malayi	protein unc-22	0.0215	0.0528	0.0528
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0275	0.0685	0.4196
Echinococcus multilocularis	acetylcholinesterase	0.0142	0.0336	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0336	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Brugia malayi	Carboxylesterase family protein	0.0024	0.0029	0.0029
Onchocerca volvulus		0.0275	0.0685	0.0738
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	hypothetical protein	0.3352	0.8719	0.9238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Onchocerca volvulus		0.0215	0.0528	0.0569
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0024	0.0029	0.0176
Schistosoma mansoni	factor for adipocyte differentiation	0.0215	0.0528	0.3233
Echinococcus granulosus	anosmin 1	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Schistosoma mansoni	protein tyrosine phosphatase	0.049	0.1247	0.7635
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.049	0.1247	0.7635
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Brugia malayi	Protein-tyrosine phosphatase	0.0275	0.0685	0.0685
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Trichomonas vaginalis	spcc417.12 protein, putative	0.0024	0.0029	0.042
Onchocerca volvulus		0.3567	0.9281	1
Loa Loa (eye worm)	carboxylesterase	0.0024	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Onchocerca volvulus		0.0275	0.0685	0.0738
Schistosoma mansoni	nephrin	0.0215	0.0528	0.3233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Echinococcus multilocularis	neuroligin	0.0024	0.0029	0.0176
Echinococcus granulosus	Fibronectin type III	0.0215	0.0528	0.3233
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0275	0.0685	0.5
Echinococcus multilocularis		0.0275	0.0685	0.4196
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	neuroglian	0.0215	0.0528	0.3233
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.049	0.1247	0.7635
Onchocerca volvulus		0.0275	0.0685	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0215	0.0528	0.3233
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0024	0.0029	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0638	0.1633	0.173
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0215	0.0528	0.3233
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Brugia malayi	myotactin form B	0.0215	0.0528	0.0528
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0275	0.0685	0.4196
Schistosoma mansoni	titin	0.0215	0.0528	0.3233
Echinococcus granulosus	para nitrobenzyl esterase	0.0024	0.0029	0.0176
Schistosoma mansoni	tripartite motif protein trim9	0.0215	0.0528	0.3233
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0275	0.0685	0.0685
Schistosoma mansoni	cell adhesion molecule	0.0215	0.0528	0.3233
Brugia malayi	Lethal protein 805	0.0215	0.0528	0.0528
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.049	0.1247	0.7635
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Schistosoma mansoni	factor for adipocyte differentiation	0.0215	0.0528	0.3233
Echinococcus granulosus	cell adhesion molecule	0.0215	0.0528	0.3233
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Echinococcus multilocularis	roundabout 2	0.0215	0.0528	0.3233
Echinococcus granulosus	roundabout 2	0.0215	0.0528	0.3233
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0215	0.0528	0.3233
Schistosoma mansoni	protein tyrosine phosphatase	0.0275	0.0685	0.4196
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0215	0.0528	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0275	0.0685	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Onchocerca volvulus	4.1 G protein, putative homolog	0.0275	0.0685	0.0738
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Brugia malayi	hypothetical protein	0.0275	0.0685	0.0685
Leishmania major	tyrosine specific protein phosphatase, putative	0.0275	0.0685	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Brugia malayi	hypothetical protein	0.0215	0.0528	0.0528
Schistosoma mansoni	ephrin receptor	0.0215	0.0528	0.3233
Schistosoma mansoni	myosin-binding protein-related	0.0215	0.0528	0.3233
Brugia malayi	myotactin form A	0.0215	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus granulosus	anosmin 1	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0275	0.0685	0.0738
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0275	0.0685	0.4196
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0215	0.0528	0.0559
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0275	0.0685	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Echinococcus multilocularis	titin	0.0215	0.0528	0.3233
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Brugia malayi	Carboxylesterase family protein	0.0142	0.0336	0.0336
Onchocerca volvulus		0.0275	0.0685	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Schistosoma mansoni	cell adhesion molecule	0.0215	0.0528	0.3233
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0215	0.0528	0.0559
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0275	0.0685	0.4196
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	roundabout 2	0.0215	0.0528	0.3233
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0013	0	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Echinococcus granulosus	titin	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus multilocularis	roundabout 2	0.0215	0.0528	0.3233
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0029	0.0176
Brugia malayi	Protein-tyrosine phosphatase 1	0.0275	0.0685	0.0685
Brugia malayi	SPRY domain containing protein	0.0215	0.0528	0.0528
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Echinococcus multilocularis	para nitrobenzyl esterase	0.0024	0.0029	0.0176
Brugia malayi	hypothetical protein	0.0024	0.0029	0.0029
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.049	0.1247	0.7635
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.049	0.1247	0.7635
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus granulosus	Netrin receptor DCC	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.0685	0.4196
Schistosoma mansoni	gliotactin	0.0024	0.0029	0.0176
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0029	0.0176
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	CAMK protein kinase	0.0215	0.0528	0.0559
Loa Loa (eye worm)	projectin	0.0215	0.0528	0.0559
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0215	0.0528	0.3233
Echinococcus multilocularis	hypothetical protein	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.3627	0.9438	1
Echinococcus granulosus	G1Y162 protein	0.0215	0.0528	0.3233
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Schistosoma mansoni	cell adhesion molecule	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus granulosus	acetylcholinesterase	0.0142	0.0336	0.2059
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0275	0.0685	0.4196
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0215	0.0528	0.0559
Loa Loa (eye worm)	UNCoordinated family member	0.0215	0.0528	0.0559
Chlamydia trachomatis	DNA topoisomerase I	0.0013	0	0.5
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0275	0.0685	0.0726
Chlamydia trachomatis	SWIB complex protein	0.0013	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.0528	0.3233
Brugia malayi	hypothetical protein	0.0275	0.0685	0.0685
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.049	0.1247	0.7635
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Onchocerca volvulus		0.0275	0.0685	0.0738
Onchocerca volvulus		0.0275	0.0685	0.0738
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Onchocerca volvulus		0.0275	0.0685	0.0738
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0024	0.0029	0.042
Onchocerca volvulus		0.0275	0.0685	0.0738
Echinococcus granulosus	nephrin	0.0215	0.0528	0.3233
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0215	0.0528	0.0559
Echinococcus granulosus	titin	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0275	0.0685	0.4196
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0215	0.0528	0.3233
Brugia malayi	hypothetical protein	0.0215	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0275	0.0685	0.4196
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0275	0.0685	0.4196
Schistosoma mansoni	cell adhesion molecule	0.0215	0.0528	0.3233
Schistosoma mansoni	hypothetical protein	0.0215	0.0528	0.3233
Trichomonas vaginalis	pten, drome, putative	0.0275	0.0685	1
Schistosoma mansoni	neuroglian	0.0215	0.0528	0.3233
Schistosoma mansoni	pcd6 interacting protein-related	0.0275	0.0685	0.4196
Onchocerca volvulus		0.0275	0.0685	0.0738
Onchocerca volvulus		0.0275	0.0685	0.0738
Brugia malayi	Fibronectin type III domain containing protein	0.0215	0.0528	0.0528
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.0528	0.0528
Echinococcus multilocularis	cell adhesion molecule	0.0215	0.0528	0.3233
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0528	0.0559
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0275	0.0685	1
Echinococcus multilocularis	anosmin 1	0.0215	0.0528	0.3233
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0685	0.0726
Echinococcus multilocularis	transfer RNA-Phe	0.0215	0.0528	0.3233
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0029	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0275	0.0685	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.003
Onchocerca volvulus		0.0215	0.0528	0.0569
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0215	0.0528	0.0559
Brugia malayi	hypothetical protein	0.0275	0.0685	0.0685
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.0685	0.0685
Echinococcus multilocularis	titin	0.0215	0.0528	0.3233
Brugia malayi	hypothetical protein	0.0275	0.0685	0.0685
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.0685	0.4196
Echinococcus multilocularis	anosmin 1	0.0215	0.0528	0.3233
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.0685	0.0726
Loa Loa (eye worm)	hypothetical protein	0.3352	0.8719	0.9238
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0024	0.0029	0.5
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0275	0.0685	0.4196
Onchocerca volvulus		0.0024	0.0029	0.0031
Loa Loa (eye worm)	hypothetical protein	0.3352	0.8719	0.9238
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.0029	0.5
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0024	0.0029	0.0176
Schistosoma mansoni	nephrin	0.0215	0.0528	0.3233

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 2 uM	Binding affinity to human wild type Mdm2 by isothermal titration calorimetry	ChEMBL.	18680271
Kd (binding)	= 2 uM	Binding affinity to human wild type Mdm2 by antagonist induced dissociation assay	ChEMBL.	18680271
Kd (binding)	= 8 uM	Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titration	ChEMBL.	18680271

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL497305

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 996869