Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0162 | 0.1217 | 0.1235 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0162 | 0.1217 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0162 | 0.1217 | 0.1235 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0162 | 0.1217 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.1015 | 0.8498 | 0.8621 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0162 | 0.1217 | 0.1235 |
Schistosoma mansoni | immunophilin | 0.1191 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1174 | 0.9858 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.1174 | 0.9858 | 1 |
Onchocerca volvulus | 0.0162 | 0.1217 | 0.9847 | |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0162 | 0.1217 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0162 | 0.1217 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0162 | 0.1217 | 0.1235 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1029 | 0.8621 | 0.8621 |
Echinococcus multilocularis | fk506 binding protein | 0.1174 | 0.9858 | 0.9858 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0162 | 0.1217 | 0.1235 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0162 | 0.1217 | 0.1235 |
Echinococcus multilocularis | 0.0162 | 0.1217 | 0.1217 | |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0178 | 0.136 | 0.136 |
Schistosoma mansoni | immunophilin | 0.1191 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1217 | 0.1217 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0162 | 0.1217 | 0.1217 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0162 | 0.1217 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1174 | 0.9858 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0162 | 0.1217 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1174 | 0.9858 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1174 | 0.9858 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1174 | 0.9858 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1174 | 0.9858 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0162 | 0.1217 | 0.1217 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1191 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1174 | 0.9858 | 0.9858 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0162 | 0.1217 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0162 | 0.1217 | 0.1235 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0162 | 0.1217 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1177 | 0.9877 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0162 | 0.1217 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0162 | 0.1217 | 0.1235 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1174 | 0.9858 | 1 |
Schistosoma mansoni | immunophilin | 0.1029 | 0.8621 | 0.8621 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1029 | 0.8621 | 0.8621 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0162 | 0.1217 | 0.1235 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Onchocerca volvulus | 0.0164 | 0.1236 | 1 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1174 | 0.9858 | 0.9978 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1191 | 1 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.1174 | 0.9858 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1174 | 0.9858 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0162 | 0.1217 | 0.1235 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0162 | 0.1217 | 0.1235 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0162 | 0.1217 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.1174 | 0.9858 | 1 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0162 | 0.1217 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1217 | 0.1235 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1174 | 0.9858 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1174 | 0.9858 | 0.9858 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1174 | 0.9858 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0162 | 0.1217 | 0.1217 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0162 | 0.1217 | 0.1235 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0162 | 0.1217 | 0.1235 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1174 | 0.9858 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1191 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 81.8 % | Channel opening activity at human BKalpha channel expressed in CHOK1 cells assessed as ionic current amplitude at 30 uM at holding potential of -90 mV by population patch clamp technique relative to untreated control | ChEMBL. | 18789860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.