Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0489 | 0.316 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0429 | 0.242 | 0.7658 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0489 | 0.316 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1043 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0234 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0489 | 0.316 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0234 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0429 | 0.242 | 0.242 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0429 | 0.242 | 0.242 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0429 | 0.242 | 0.242 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0489 | 0.316 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0429 | 0.242 | 0.242 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1043 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0429 | 0.242 | 0.242 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1043 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1043 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1043 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0429 | 0.242 | 0.242 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1043 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1043 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1043 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0429 | 0.242 | 0.242 |
Brugia malayi | CHE-14 protein | 0.0429 | 0.242 | 0.242 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.242 | 0.242 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1043 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0429 | 0.242 | 0.242 |
Echinococcus multilocularis | protein dispatched 1 | 0.0429 | 0.242 | 0.242 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0429 | 0.242 | 0.242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 57 % | Inhibition of Stat3 binding to DNA in human U266 whole cell lysate at 100 ug/ml by ELISA | ChEMBL. | 18768317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.