Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0484 | 0.0387 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0484 | 0.0732 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0512 | 0.0775 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.3797 | 0.568 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.01 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.01 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.01 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.2264 | 0.7396 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0484 | 0.1311 |
Onchocerca volvulus | 0.0157 | 0.3892 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0244 | 0.6609 | 0.6575 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3892 | 0.5825 |
Brugia malayi | hypothetical protein | 0.0157 | 0.3892 | 0.5888 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0234 | 0.6298 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0577 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3025 | 0.4494 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.01 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2264 | 0.3324 |
Brugia malayi | beta-lactamase | 0.0037 | 0.01 | 0.0151 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0577 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0577 | 0.0872 |
Onchocerca volvulus | 0.005 | 0.0512 | 0.1087 | |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3025 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0352 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.01 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0484 | 0.0732 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3025 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.01 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3025 | 0.4577 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3025 | 0.4494 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.01 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0577 | 0.0732 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0484 | 0.0387 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0567 | 0.1597 |
Onchocerca volvulus | 0.0051 | 0.0567 | 0.1232 | |
Brugia malayi | hypothetical protein | 0.0244 | 0.6609 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.2787 | 0.4217 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.3797 | 0.5745 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3025 | 0.2955 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3025 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.3797 | 0.568 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3025 | 0.4577 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.01 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0567 | 0.0718 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0484 | 0.0387 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0484 | 0.0589 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0244 | 0.6609 | 0.6575 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0484 | 0.1311 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0577 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0577 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0484 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.6609 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.01 | 0.5 |
Brugia malayi | RNA binding protein | 0.013 | 0.3025 | 0.4577 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0512 | 0.1409 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0577 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.3797 | 0.5745 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.2264 | 0.3425 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0484 | 0.0589 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.01 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0577 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.2787 | 0.4128 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0484 | 0.1311 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.01 | 0.0151 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3025 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.01 | 0.0151 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3025 | 0.2955 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.01 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0512 | 0.1409 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.01 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0484 | 0.1311 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.0577 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3025 | 0.4494 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0484 | 0.0387 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.2787 | 0.4128 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0484 | 0.0387 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.