TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.597 | Formula: C24H28N8O2S
H donors: 3 H acceptors: 4 LogP: 2.61 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(C)(C)Cc2c1sc(n2)N1CCOc2c1cc(cc2)Nc1ccc(nn1)N1CCNCC1
InChi: 1S/C24H28N8O2S/c1-24(2)14-16-21(22(33)28-24)35-23(27-16)32-11-12-34-18-4-3-15(13-17(18)32)26-19-5-6-20(30-29-19)31-9-7-25-8-10-31/h3-6,13,25H,7-12,14H2,1-2H3,(H,26,29)(H,28,33)
InChiKey: AMEKXJGPLKONNT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	alpha-tubulin	0.0215	0.2426	0.2426
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0215	0.2426	0.3069
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0087	0.0069	0.0212
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0215	0.2426	0.742
Trypanosoma brucei	beta tubulin	0.0255	0.3174	1
Leishmania major	beta tubulin	0.0255	0.3174	1
Leishmania major	beta tubulin	0.0255	0.3174	1
Giardia lamblia	Gamma tubulin	0.0147	0.1181	0.167
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Brugia malayi	tubulin alpha-2 chain	0.0215	0.2426	0.2426
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0087	0.0069	0.0069
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0169	0.1575	0.0982
Echinococcus multilocularis	tubulin alpha 1C chain	0.0215	0.2426	0.3102
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0252	0.3126	0.9555
Trypanosoma brucei	beta tubulin	0.0255	0.3174	1
Brugia malayi	Tubulin gamma chain	0.0147	0.1181	0.1181
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0207	0.2287	0.6931
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0255	0.3174	0.9712
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Echinococcus multilocularis	tubulin alpha 3 chain	0.0215	0.2426	0.3102
Plasmodium vivax	tubulin alpha chain, putative	0.0215	0.2426	0.6243
Echinococcus multilocularis	tubulin alpha 3 chain	0.0215	0.2426	0.3102
Echinococcus granulosus	tubulin alpha chain	0.0215	0.2426	0.3102
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0167	0.154	0.4712
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.0386	0.0386
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Trichomonas vaginalis	tubulin beta chain, putative	0.0255	0.3174	0.9712
Giardia lamblia	Beta tubulin	0.0255	0.3174	1
Loa Loa (eye worm)	tubulin beta chain	0.0255	0.3174	0.4081
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0087	0.0069	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0492	0.7554	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0151	0.1245	0.1473
Schistosoma mansoni	alpha tubulin	0.0215	0.2426	0.4598
Echinococcus multilocularis	tubulin alpha chain	0.0215	0.2426	0.3102
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Toxoplasma gondii	beta-1 tubulin, putative	0.0255	0.3174	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1575	0.1919
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Plasmodium falciparum	alpha tubulin 1	0.0215	0.2426	0.6243
Echinococcus multilocularis	peroxisome assembly protein 26	0.0215	0.2426	0.3102
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0131	0.0887	0.2712
Trypanosoma brucei	epsilon tubulin	0.0147	0.1181	0.372
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Loa Loa (eye worm)	alpha-tubulin	0.0215	0.2426	0.3069
Loa Loa (eye worm)	tubulin alpha chain	0.0215	0.2426	0.3069
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Echinococcus granulosus	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Entamoeba histolytica	tubulin alpha-1 chain	0.0215	0.2426	0.7364
Echinococcus granulosus	alpha tubulin	0.0215	0.2426	0.3102
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.026	0.3269	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0255	0.3174	0.4081
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0167	0.154	0.4712
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus granulosus	tubulin alpha chain	0.0215	0.2426	0.3102
Echinococcus multilocularis	tubulin alpha 1C chain	0.0215	0.2426	0.3102
Onchocerca volvulus		0.0083	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Loa Loa (eye worm)	tubulin beta-1 chain	0.0255	0.3174	0.4081
Echinococcus granulosus	tubulin alpha chain	0.0215	0.2426	0.3102
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0887	0.0989
Giardia lamblia	Beta tubulin	0.0255	0.3174	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0167	0.154	0.3171
Plasmodium falciparum	tubulin beta chain	0.0255	0.3174	1
Trichomonas vaginalis	tubulin, putative	0.0255	0.3174	0.9712
Trichomonas vaginalis	tubulin gamma chain, putative	0.0147	0.1181	0.3613
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Plasmodium vivax	tubulin alpha chain, putative	0.0215	0.2426	0.6243
Loa Loa (eye worm)	hypothetical protein	0.0264	0.3346	0.4313
Trypanosoma brucei	beta tubulin	0.0255	0.3174	1
Echinococcus multilocularis	beta tubulin	0.0255	0.3174	0.4968
Loa Loa (eye worm)	hypothetical protein	0.0132	0.09	0.1007
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Toxoplasma gondii	beta-tubulin, putative	0.0255	0.3174	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0179	0.1763	0.5394
Echinococcus granulosus	tubulin alpha 3 chain	0.0215	0.2426	0.3102
Plasmodium vivax	tubulin beta chain, putative	0.0255	0.3174	1
Trypanosoma brucei	alpha tubulin	0.0215	0.2426	0.7641
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.1575	0.1575
Trichomonas vaginalis	tubulin alpha chain, putative	0.0255	0.3174	0.9712
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0167	0.154	0.4712
Echinococcus granulosus	tubulin subunit TubB	0.0215	0.2426	0.3102
Echinococcus granulosus	tubulin alpha 3 chain	0.0215	0.2426	0.3102
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0364	0.5194	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Trypanosoma brucei	alpha tubulin	0.0215	0.2426	0.7641
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0179	0.1763	0.5394
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0255	0.3174	0.4968
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus multilocularis	tubulin alpha chain	0.0215	0.2426	0.3102
Echinococcus multilocularis	tubulin alpha chain	0.0215	0.2426	0.3102
Schistosoma mansoni	tubulin subunit epsilon	0.0147	0.1181	0.2169
Leishmania major	beta tubulin	0.0255	0.3174	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0151	0.1245	0.3808
Loa Loa (eye worm)	tubulin alpha chain	0.0215	0.2426	0.3069
Trypanosoma cruzi	tubulin gamma chain	0.0147	0.1181	0.3474
Echinococcus granulosus	tubulin beta 1 chain	0.0255	0.3174	0.4968
Trypanosoma cruzi	alpha tubulin, putative	0.0215	0.2426	0.7364
Giardia lamblia	NADPH oxidoreductase, putative	0.0167	0.154	0.3171
Echinococcus granulosus	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Echinococcus granulosus	peroxisome assembly protein 26	0.0215	0.2426	0.3102
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.026	0.3269	1
Toxoplasma gondii	beta tubulin	0.0255	0.3174	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0311	0.4212	0.5483
Echinococcus granulosus	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Brugia malayi	Tubulin alpha-2 chain	0.0215	0.2426	0.2426
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0215	0.2426	0.742
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Loa Loa (eye worm)	BEN-1 protein	0.0255	0.3174	0.4081
Leishmania major	beta tubulin	0.0255	0.3174	1
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus granulosus	tubulin subunit beta	0.0255	0.3174	0.4968
Loa Loa (eye worm)	tubulin alpha 2	0.0151	0.1245	0.1473
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Echinococcus granulosus	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Trypanosoma brucei	alpha tubulin	0.0215	0.2426	0.7641
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.026	0.3269	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2426	0.3069
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Brugia malayi	Tubulin alpha chain	0.0215	0.2426	0.2426
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Leishmania major	beta tubulin	0.0255	0.3174	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0115	0.0593	0.1637
Trichomonas vaginalis	tubulin gamma chain, putative	0.0255	0.3174	0.9712
Echinococcus multilocularis	tubulin subunit TubB	0.0215	0.2426	0.3102
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0255	0.3174	0.9712
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0131	0.0887	0.0989
Echinococcus multilocularis	tubulin beta 1 chain	0.0255	0.3174	0.4968
Leishmania major	beta tubulin	0.0255	0.3174	1
Trypanosoma cruzi	beta tubulin, putative	0.0255	0.3174	0.9705
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0228	0.2669	0.5073
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0087	0.0069	0.0218
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0364	0.5194	1
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Trypanosoma brucei	beta tubulin	0.0147	0.1181	0.372
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.026	0.3269	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0147	0.1181	0.3474
Echinococcus granulosus	beta tubulin	0.0255	0.3174	0.4968
Giardia lamblia	Alpha-tubulin	0.0215	0.2426	0.6871
Echinococcus multilocularis	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Toxoplasma gondii	alpha tubulin TUBA1	0.0215	0.2426	0.6243
Schistosoma mansoni	alpha tubulin	0.0215	0.2426	0.4598
Entamoeba histolytica	tubulin family protein	0.0255	0.3174	0.9705
Echinococcus granulosus	tubulin alpha 1C chain	0.0215	0.2426	0.3102
Leishmania major	beta tubulin	0.0255	0.3174	1
Entamoeba histolytica	tubulin family protein	0.0255	0.3174	0.9705
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Leishmania major	beta tubulin	0.0255	0.3174	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0215	0.2426	0.7364
Echinococcus granulosus	tubulin alpha chain	0.0215	0.2426	0.3102
Trypanosoma cruzi	epsilon tubulin, putative	0.0147	0.1181	0.3474
Giardia lamblia	Alpha-tubulin	0.0215	0.2426	0.6871
Leishmania major	beta tubulin	0.0255	0.3174	1
Schistosoma mansoni	tubulin subunit alpha	0.0215	0.2426	0.4598
Schistosoma mansoni	tubulin subunit alpha	0.0215	0.2426	0.4598
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0215	0.2426	0.742
Trichomonas vaginalis	tubulin alpha chain, putative	0.0147	0.1181	0.3613
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Entamoeba histolytica	hypothetical protein	0.0207	0.2287	0.6931
Leishmania major	alpha tubulin	0.0215	0.2426	0.6243
Echinococcus multilocularis	tubulin subunit beta	0.0255	0.3174	0.4968
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0215	0.2426	0.3102
Echinococcus multilocularis	hypothetical protein	0.0215	0.2426	0.3102
Schistosoma mansoni	alpha tubulin	0.0215	0.2426	0.4598
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0169	0.1575	0.0982
Loa Loa (eye worm)	tubulin beta-2A chain	0.0255	0.3174	0.4081
Echinococcus multilocularis	tubulin alpha chain	0.0215	0.2426	0.3102
Toxoplasma gondii	alpha-tubulin I, putative	0.0215	0.2426	0.6243
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1245	0.1473
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Brugia malayi	Tubulin alpha-2 chain	0.0215	0.2426	0.2426
Echinococcus multilocularis	beta tubulin	0.0255	0.3174	0.4968
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Leishmania major	beta tubulin	0.0255	0.3174	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Echinococcus granulosus	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Trypanosoma brucei	tubulin gamma chain	0.0147	0.1181	0.372
Schistosoma mansoni	tubulin subunit beta	0.0255	0.3174	0.606
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.026	0.3269	1
Loa Loa (eye worm)	BEN-1 protein	0.0255	0.3174	0.4081
Echinococcus multilocularis	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Plasmodium falciparum	alpha tubulin 2	0.0215	0.2426	0.6243
Brugia malayi	tubulin alpha chain - mouse	0.0215	0.2426	0.2426
Loa Loa (eye worm)	tubulin alpha 2	0.0151	0.1245	0.1473
Echinococcus granulosus	tubulin beta 4A class IVa	0.0255	0.3174	0.4968
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Entamoeba histolytica	tubulin gamma chain	0.0147	0.1181	0.3474
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0364	0.5194	1
Leishmania major	beta tubulin	0.0255	0.3174	1
Loa Loa (eye worm)	tubulin gamma chain	0.0147	0.1181	0.1387
Trypanosoma brucei	alpha tubulin	0.0215	0.2426	0.7641
Schistosoma mansoni	tubulin subunit alpha	0.0215	0.2426	0.4598
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.026	0.3269	0.3269
Giardia lamblia	NADPH oxidoreductase, putative	0.0167	0.154	0.3171
Echinococcus multilocularis	tubulin alpha chain	0.0215	0.2426	0.3102
Loa Loa (eye worm)	alpha-tubulin	0.0215	0.2426	0.3069
Leishmania major	beta tubulin	0.0255	0.3174	1
Loa Loa (eye worm)	beta-tubulin	0.0255	0.3174	0.4081
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.026	0.3269	1
Trypanosoma brucei	beta tubulin	0.0255	0.3174	1
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.154	0.4712
Trypanosoma brucei	epsilon tubulin	0.0147	0.1181	0.372
Echinococcus multilocularis	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Leishmania major	beta tubulin	0.0255	0.3174	1
Giardia lamblia	Beta tubulin	0.0255	0.3174	1
Brugia malayi	Tubulin beta-1 chain	0.0255	0.3174	0.3174
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0087	0.0069	0.0212
Brugia malayi	beta-tubulin, identical	0.0255	0.3174	0.3174
Echinococcus granulosus	Tubulin alpha 1 chain	0.0215	0.2426	0.3102
Trichomonas vaginalis	tubulin gamma chain, putative	0.0147	0.1181	0.3613
Echinococcus granulosus	beta tubulin	0.0255	0.3174	0.4968
Trichomonas vaginalis	tubulin beta chain, putative	0.0215	0.2426	0.742
Trypanosoma brucei	epsilon tubulin	0.0147	0.1181	0.372
Echinococcus granulosus	Tubulin beta 2C chain	0.0255	0.3174	0.4968
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.0771	0.2358
Schistosoma mansoni	tubulin subunit gamma	0.0147	0.1181	0.2169
Echinococcus granulosus	tubulin alpha chain	0.0215	0.2426	0.3102

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 nM	Inhibition of PI3Kdelta	ChEMBL.	18774713
IC50 (binding)	= 34 nM	Inhibition of PI3Kgamma	ChEMBL.	18774713

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL491440

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 997060