Detailed information for compound 997132

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.524 | Formula: C26H27N5O4
  • H donors: 2 H acceptors: 3 LogP: 2.87 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc2ccc(nc2n(c1=O)CCNC(=O)C)NCc1cccc(c1)OC
  • InChi: 1S/C26H27N5O4/c1-17(32)27-13-14-31-25-22(29-24(26(31)33)19-7-9-20(34-2)10-8-19)11-12-23(30-25)28-16-18-5-4-6-21(15-18)35-3/h4-12,15H,13-14,16H2,1-3H3,(H,27,32)(H,28,30)
  • InChiKey: YMSXWSZJIGJSRC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0134 0.1416 0.1415
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1326 0.2076
Onchocerca volvulus 0.0016 0.0072 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0497 0.0739
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0072 0.004
Echinococcus granulosus tar DNA binding protein 0.007 0.0685 0.1104
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0213 0.0342
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0123 0.1288 0.2017
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.0023
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0016 0.0072 0.0067
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0747 0.1159
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0294 0.0475
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0072 0.0116
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0262 0.0421
Toxoplasma gondii propionate-CoA ligase 0.0016 0.0072 0.0116
Entamoeba histolytica phosphofructokinase, putative 0.012 0.125 0.1976
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0093 0.0092
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0747 0.1203
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.046 0.0459
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0093 0.0149
Mycobacterium ulcerans 2-dehydropantoate 2-reductase 0.012 0.1252 0.1964
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0606 0.0606
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0138 0.0147
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0427 0.0641
Loa Loa (eye worm) phosphofructokinase 0.012 0.125 0.2016
Mycobacterium ulcerans hypothetical protein 0.0053 0.0497 0.0739
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.015 0.0241
Onchocerca volvulus 0.0016 0.0072 0.0048
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0072 0.0067
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.015 0.015
Brugia malayi Pre-SET motif family protein 0.0063 0.0606 0.0977
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0262 0.0421
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0497 0.0776
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.125 0.2016
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0558 0.6202 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0091 0.008
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0059 0.0558 0.0875
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0552 0.089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0138 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.047 0.071
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.0023
Brugia malayi hypothetical protein 0.0022 0.015 0.0241
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0016 0.0072 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0072 0.0089
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0072 0.0067
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0262 0.1701
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0262 0.0374
Entamoeba histolytica adenosylhomocysteinase, putative 0.0558 0.6202 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.1833 0.2955
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.1252 0.1956
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0123 0.1288 0.2015
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0388 0.0388
Brugia malayi hypothetical protein 0.0171 0.1833 0.2954
Brugia malayi dihydrofolate reductase family protein 0.0125 0.1315 0.2119
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0091 0.0039
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0091 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0321 0.0443
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0383 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0093 0.0149
Loa Loa (eye worm) oxidoreductase 0.0016 0.0072 0.0117
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0249 0.2707 0.4348
Loa Loa (eye worm) thymidylate synthase 0.0123 0.1288 0.2076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0138 0.0156
Echinococcus granulosus RUN 0.0022 0.015 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Echinococcus multilocularis RUN 0.0022 0.015 0.015
Brugia malayi Pre-SET motif family protein 0.0438 0.4848 0.7816
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0046 0.0024
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0072 0.0043
Onchocerca volvulus 0.0022 0.015 0.019
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0747 0.1203
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1182 0.1843
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0558 0.6202 1
Brugia malayi PAS domain containing protein 0.0051 0.0473 0.0762
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0072 0.004
Echinococcus multilocularis tar DNA binding protein 0.007 0.0685 0.0685
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0285 0.0459
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0262 0.0374
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0072 0.004
Mycobacterium tuberculosis Hypothetical protein 0.0059 0.0558 0.0829
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0383 0.0616
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0138 0.0222
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0091 0.2377
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.046 0.0741
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.015 0.0241
Toxoplasma gondii exonuclease III APE 0.0021 0.0138 0.0222
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0147
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0093 0.015
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0556
Echinococcus granulosus tumor protein p63 0.0355 0.3906 0.6297
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0091 0.0358
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0042 0.0068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0345 0.0492
Brugia malayi Adenosylhomocysteinase 0.0558 0.6202 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0093 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0149 0.0191
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0091 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.125 0.1976
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0072 0.0116
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1702 0.2744
Echinococcus multilocularis dihydrofolate reductase 0.0125 0.1315 0.1314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0091 0.012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0497 0.0732
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.046 0.0716
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0046 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0606 0.0977
Echinococcus granulosus adenosylhomocysteinase 0.0558 0.6202 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0427 0.0688
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1326 0.2076
Brugia malayi phosphofructokinase 0.012 0.125 0.2015
Brugia malayi glutathione reductase 0.005 0.046 0.0741
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0046 0.0046
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0091 0.0147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0117
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0016 0.0072 0.0049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0091 0.0039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0091 0.6127
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.0072 0.004
Schistosoma mansoni tar DNA-binding protein 0.007 0.0685 0.1104
Schistosoma mansoni polycystin 1-related 0.0022 0.015 0.0241
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0556
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0093 0.0122
Leishmania major protein kinase, putative 0.0013 0.0046 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0093 0.0092
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0249 0.2707 0.4348
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1702 0.1702
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0345 0.2356
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0747 0.118
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0072 0.0089
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0138 0.0116
Schistosoma mansoni lipoxygenase 0.0094 0.0959 0.1545
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0091 0.0097
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0262 0.1471
Schistosoma mansoni hypothetical protein 0.0022 0.015 0.0241
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0046 0.0047
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0046 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0383 0.057
Schistosoma mansoni rab6-interacting 0.0022 0.015 0.0241
Echinococcus multilocularis musashi 0.0058 0.0552 0.0552
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0249 0.2707 0.4348
Onchocerca volvulus 0.0053 0.0497 0.0822
Trichomonas vaginalis hypothetical protein 0.0069 0.0678 0.1048
Brugia malayi RNA binding protein 0.007 0.0685 0.1104
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0072 0.0116
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0323 0.052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0091
Plasmodium vivax acetyl-CoA synthetase, putative 0.0016 0.0072 0.0009
Leishmania major trypanothione reductase 0.005 0.046 0.0716
Echinococcus granulosus dihydrofolate reductase 0.0125 0.1315 0.2119
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.015 0.0241
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0093 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0091 0.012
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0556
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0497 0.0739
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0747 0.1203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0606 0.0977
Loa Loa (eye worm) doublecortin family protein 0.0022 0.015 0.0242
Schistosoma mansoni ap endonuclease 0.0021 0.0138 0.0222
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0093 0.0122
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0016 0.0072 0.0049
Schistosoma mansoni ap endonuclease 0.0021 0.0138 0.0222
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0123 0.1288 0.2076
Echinococcus granulosus bloom syndrome protein 0.0022 0.0149 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.125 0.1976
Leishmania major cytochrome p450-like protein 0.0013 0.0042 0.004
Echinococcus granulosus 6 phosphofructokinase 0.012 0.125 0.2015
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0556
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0024
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.125 0.1956
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0093 0.0149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1326 0.2079
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0072 0.0089
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0552 0.089
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.015 0.015
Onchocerca volvulus 0.0038 0.0323 0.0505
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0125 0.1315 0.2066
Plasmodium falciparum thioredoxin reductase 0.0017 0.0091 0.0147
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0249 0.2707 0.4363
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0262 0.6837
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0558 0.6202 1
Brugia malayi intermediate filament protein 0.0058 0.0552 0.0889
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0262 0.0421
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1326 0.2076
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0117
Schistosoma mansoni tar DNA-binding protein 0.007 0.0685 0.1104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0606 0.0977
Loa Loa (eye worm) adenosylhomocysteinase 0.0558 0.6202 1
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0558 0.6202 1
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0483 0.0778
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0249 0.2707 0.4363
Schistosoma mansoni lamin 0.0058 0.0552 0.0889
Echinococcus multilocularis adenosylhomocysteinase 0.0558 0.6202 0.6202
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0042 0.004
Plasmodium falciparum thioredoxin reductase 0.005 0.046 0.0741
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.015 0.015
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0091 0.012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0072 0.0116
Brugia malayi Thioredoxin reductase 0.005 0.046 0.0741
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.0801
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0497 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.031 0.34 0.5459
Echinococcus multilocularis expressed protein 0.0035 0.0294 0.0294
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0096 0.0154
Echinococcus granulosus lamin dm0 0.0058 0.0552 0.0889
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0285 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0558 0.0854
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Brugia malayi Doublecortin family protein 0.0022 0.015 0.0241
Brugia malayi 6-phosphofructokinase 0.012 0.125 0.2015
Brugia malayi isocitrate dehydrogenase 0.0017 0.0093 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0091 0.008
Trichomonas vaginalis rotamase, putative 0.0035 0.0294 0.0426
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.046 0.0669
Schistosoma mansoni lipoxygenase 0.0134 0.1416 0.2282
Echinococcus multilocularis tumor protein p63 0.0355 0.3906 0.3905
Loa Loa (eye worm) hypothetical protein 0.0052 0.0483 0.0779
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0072 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0556
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1182 0.1843
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0138 0.0174
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0091 0.012
Brugia malayi hypothetical protein 0.0059 0.0558 0.0899
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0138 0.0174
Leishmania major ATP-dependent phosphofructokinase 0.012 0.125 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.012 0.125 0.1976
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0072 0.004
Onchocerca volvulus 0.0052 0.0483 0.0796
Echinococcus granulosus expressed protein 0.0035 0.0294 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0042 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0321 0.0443
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0249 0.2707 0.4302
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0606 0.0977
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0093 0.0073
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.125 0.125
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.0242
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0268 0.2925 0.4716
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0046 0.0047
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0072 0.004
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0427 0.0641
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0046 0.0024
Echinococcus multilocularis lamin dm0 0.0058 0.0552 0.0552
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0091 0.0147
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0262 0.0421
Schistosoma mansoni rotamase 0.0035 0.0294 0.0474
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0138 0.0405
Chlamydia trachomatis dihydrofolate reductase 0.0125 0.1315 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0072 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0016 0.0072 0.0116
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0046 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0497 0.08
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0497 0.073
Onchocerca volvulus 0.0063 0.0606 0.1021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0091 0.012
Echinococcus granulosus thymidylate synthase 0.0123 0.1288 0.2076
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0046 0.0024
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0001
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0016 0.0072 0.0116
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0285 0.0433
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0138 0.0196
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0093 0.0149
Schistosoma mansoni tar DNA-binding protein 0.007 0.0685 0.1104
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0091 0.6127
Toxoplasma gondii 3-methyl-2-oxobutanoate hydroxymethyltransferase 0.031 0.34 0.5481
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0247 0.0398
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0072 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0138 0.0138
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.1683 0.2713
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0072 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0072 0.0116
Trypanosoma brucei trypanothione reductase 0.005 0.046 0.0716
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0558 0.6202 1
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0345 0.0555
Schistosoma mansoni loxhd1 0.0022 0.015 0.0241
Brugia malayi 6-phosphofructokinase 0.012 0.125 0.2015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0093 0.0092
Brugia malayi Cytochrome P450 family protein 0.0013 0.0042 0.0067
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0285 0.0411
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.125 0.1976
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.125 0.1954
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0093 0.0092
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0175 0.1876 0.2989
Loa Loa (eye worm) dihydrofolate reductase 0.0125 0.1315 0.212
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0091 0.012
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0125 0.1315 0.2059
Toxoplasma gondii thioredoxin reductase 0.005 0.046 0.0741
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0072 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0497 0.0776
Brugia malayi thymidylate synthase 0.0123 0.1288 0.2076
Toxoplasma gondii adenosylhomocysteinase, putative 0.0558 0.6202 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.125 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0138 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0321 0.0443
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0552 0.089
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0042 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1651 0.2662
Plasmodium falciparum glutathione reductase 0.005 0.046 0.0741
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0093 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0285 0.0433
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0747 0.118
Loa Loa (eye worm) acetyltransferase 0.016 0.1702 0.2744
Plasmodium vivax thioredoxin reductase, putative 0.005 0.046 0.064
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0016 0.0072 0.0049
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0118 0.019
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0552 0.0889
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0262 0.0421
Schistosoma mansoni adenosylhomocysteinase 0.0345 0.3799 0.6124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0091 0.012
Loa Loa (eye worm) thioredoxin reductase 0.005 0.046 0.0741
Echinococcus granulosus intermediate filament protein 0.0058 0.0552 0.0889
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.125 0.1962
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0016 0.0072 0.0049
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0262 0.0317
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0016 0.0072 0.0043
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0017 0.0027
Plasmodium vivax SET domain protein, putative 0.0063 0.0606 0.0879
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0091 0.012
Leishmania major protein kinase, putative 0.0013 0.0046 0.0047
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0091 0.008
Echinococcus granulosus single minded 2 0.0038 0.0323 0.052
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Schistosoma mansoni 6-phosphofructokinase 0.012 0.125 0.2015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0497 0.0755
Plasmodium falciparum adenosylhomocysteinase 0.0558 0.6202 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0606 0.0977
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0138 0.0174
Plasmodium vivax glutathione reductase, putative 0.005 0.046 0.064
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1702 0.2744
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0606 0.0977
Echinococcus multilocularis lamin 0.0058 0.0552 0.0552
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0213 0.0212
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0262 0.0317
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0046 0.0073
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0134 0.1416 0.2282
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0046 0.0046
Brugia malayi Cytochrome P450 family protein 0.0013 0.0042 0.0067
Onchocerca volvulus 0.0498 0.5532 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0072 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.004 0.0063
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0558 0.6202 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0138 0.0196
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0323 0.0323
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0747 0.118
Schistosoma mansoni single-minded 0.0051 0.0473 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0294 0.0426
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0558 0.6202 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0091 0.0071
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0072 0.004
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0558 0.6202 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0321 0.0443
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0138 0.0223
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1182 0.1846
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.015 0.0135
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.0497 0.0739
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0323
Loa Loa (eye worm) TAR-binding protein 0.007 0.0685 0.1105
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0016 0.0072 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0042 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0606 0.0977
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.015 0.0241
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0323 0.0457
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0072 0.0116
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0345 0.0483
Loa Loa (eye worm) glutathione reductase 0.005 0.046 0.0741
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0247 0.0399
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0138 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0747 0.0746
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1182 0.1843
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0046 0.0074
Loa Loa (eye worm) RNA binding protein 0.007 0.0685 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.031 0.34 0.5459
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0072 0.0089
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0065 0.0104
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0016 0.0072 0.0049
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0016 0.0072 0.0116
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0091 0.012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.0242
Trichomonas vaginalis set domain proteins, putative 0.0498 0.5532 0.8913
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0497 0.0732
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0046 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0685 0.1105
Onchocerca volvulus 0.0022 0.015 0.019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0093 0.0092
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0125 0.1315 0.2061
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0093 0.0149
Mycobacterium ulcerans thymidylate synthase 0.0123 0.1288 0.2022
Mycobacterium tuberculosis Probable reductase 0.0114 0.1182 0.1843
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0294 0.0474
Onchocerca volvulus 0.0016 0.0072 0.0048
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.0072 0.0089
Onchocerca volvulus 0.0016 0.0072 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.000000000076761
Loa Loa (eye worm) hypothetical protein 0.0057 0.054 0.0871
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0149 0.0191
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0747 0.1204
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0268 0.2925 0.4716
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0497 0.0755
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0046 0.0024
Schistosoma mansoni rab6-interacting 0.0022 0.015 0.0241
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0427 0.0587
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0072 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0497 0.08
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.004 0.0063
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0046 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0091 0.0147
Schistosoma mansoni adenosylhomocysteinase 0.0345 0.3799 0.6124
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0497 0.0739
Trichomonas vaginalis rotamase, putative 0.0034 0.0285 0.0411
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0072 0.0089
Plasmodium falciparum glutathione reductase 0.0017 0.0091 0.0147
Schistosoma mansoni 6-phosphofructokinase 0.012 0.125 0.2015
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0072 0.0117
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.0497 0.0755
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0046 0.0047
Schistosoma mansoni dihydrofolate reductase 0.0125 0.1315 0.2119
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0093 0.0149
Echinococcus granulosus lamin 0.0058 0.0552 0.0889
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0042 0.0068
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0046 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0138 0.0222
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0558 0.6202 1
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0685 0.1104
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.0801
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.0497 0.0739
Schistosoma mansoni lamin 0.0058 0.0552 0.0889
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0323
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.0497 0.0739
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.0497 0.073
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0091 0.0097
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0262 0.1701
Schistosoma mansoni tar DNA-binding protein 0.007 0.0685 0.1104
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Entamoeba histolytica phosphofructokinase, putative 0.012 0.125 0.1976
Brugia malayi Dihydrofolate reductase 0.0125 0.1315 0.2119
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.125 0.1994
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0158
Schistosoma mansoni adenosylhomocysteinase 0.0345 0.3799 0.6124
Loa Loa (eye worm) RecQ helicase 0.0022 0.0149 0.0241
Brugia malayi TAR-binding protein 0.007 0.0685 0.1104
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0747 0.118
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0268 0.2925 0.2925
Schistosoma mansoni tar DNA-binding protein 0.007 0.0685 0.1104
Mycobacterium ulcerans ketopantoate reductase, ApbA 0.031 0.34 0.5451
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0427 0.0688
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1182 0.1843
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0345 0.0453
Mycobacterium ulcerans acetyl-CoA synthetase 0.0016 0.0072 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0138 0.0222
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.125 0.1976
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0262 0.0374
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0093 0.0122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.058 0.0935
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0016 0.0072 0.0043
Onchocerca volvulus 0.0058 0.0552 0.0922
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0285 0.0433
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.125 0.2016
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1182 0.1843
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.125 0.1994
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0138 0.3605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0072 0.004
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0072 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0213 0.0343
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0072 0.0049
Leishmania major S-adenosylhomocysteine hydrolase 0.0558 0.6202 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0149 0.024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.0801
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Brugia malayi hypothetical protein 0.0022 0.015 0.0241
Schistosoma mansoni adenosylhomocysteinase 0.0558 0.6202 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0427 0.0688
Echinococcus multilocularis thymidylate synthase 0.0123 0.1288 0.1287
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0606 0.0606
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0497 0.0776
Brugia malayi hypoxia-induced factor 1 0.0158 0.1683 0.2712
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0473 0.0762
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.4848 0.7816
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0388 0.0625
Schistosoma mansoni intermediate filament proteins 0.0058 0.0552 0.0889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0074
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0072 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0091 0.012
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0046 0.0024
Onchocerca volvulus 0.0058 0.0552 0.0922
Onchocerca volvulus 0.0123 0.1288 0.2264
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0497 0.08
Schistosoma mansoni adenosylhomocysteinase 0.0345 0.3799 0.6124
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0558 0.6202 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0072 0.0089

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of Delta-9-desaturase in human HepG2 cells ChEMBL. 19249203

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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