TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 303.79 | Formula: C15H18ClN5
H donors: 1 H acceptors: 2 LogP: 2.41 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1nc(N)nc(c1)c1ccc(cc1)Cl
InChi: 1S/C15H18ClN5/c1-20-6-8-21(9-7-20)14-10-13(18-15(17)19-14)11-2-4-12(16)5-3-11/h2-5,10H,6-9H2,1H3,(H2,17,18,19)
InChiKey: YYUPHZVTHXGIJI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histamine receptor H4	Starlite/ChEMBL	References
Rattus norvegicus	Histamine H4 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Histamine H4 receptor	391 aa	362 aa	25.4 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Histamine H4 receptor	391 aa	355 aa	21.7 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Histamine H4 receptor	391 aa	374 aa	26.5 %
Schistosoma japonicum	ko:K04255 opsin 4 (melanopsin), putative	Histamine H4 receptor	391 aa	396 aa	19.7 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Histamine H4 receptor	391 aa	363 aa	27.3 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Histamine H4 receptor	391 aa	374 aa	25.9 %
Schistosoma mansoni	amine GPCR	Histamine H4 receptor	391 aa	426 aa	23.9 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Histamine H4 receptor	391 aa	391 aa	25.1 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Histamine H4 receptor	391 aa	385 aa	20.5 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Histamine H4 receptor	391 aa	390 aa	24.4 %
Onchocerca volvulus		Histamine H4 receptor	391 aa	406 aa	22.9 %
Loa Loa (eye worm)	hypothetical protein	Histamine H4 receptor	391 aa	377 aa	22.8 %
Echinococcus multilocularis	serotonin receptor	Histamine H4 receptor	391 aa	406 aa	24.4 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Histamine H4 receptor	391 aa	331 aa	24.5 %
Echinococcus multilocularis	neuropeptides capa receptor	Histamine H4 receptor	391 aa	417 aa	21.8 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Histamine H4 receptor	391 aa	355 aa	21.7 %
Echinococcus granulosus	biogenic amine 5HT receptor	Histamine H4 receptor	391 aa	405 aa	24.2 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Histamine H4 receptor	391 aa	342 aa	24.9 %
Onchocerca volvulus		Histamine H4 receptor	391 aa	401 aa	22.7 %
Brugia malayi	sulfakinin receptor protein	Histamine H4 receptor	391 aa	344 aa	19.5 %
Echinococcus granulosus	g protein coupled receptor	Histamine H4 receptor	391 aa	327 aa	24.2 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Histamine H4 receptor	391 aa	401 aa	26.2 %
Loa Loa (eye worm)	hypothetical protein	Histamine H4 receptor	391 aa	376 aa	24.5 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Histamine H4 receptor	391 aa	396 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0432	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.1189	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0826	0.1059
Onchocerca volvulus		0.0059	0.126	0.2168
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0103	0.2331	0.2986
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0263	0.0263
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0091	0.0091
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0251	0.0251
Brugia malayi	TAR-binding protein	0.0276	0.6603	0.846
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0271	0.0505
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0452	1
Brugia malayi	Smad1	0.0018	0.0251	0.0322
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0432	0.3
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.126	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0271	0.0348
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1189	0.1523
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.0826	0.1059
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0263	0.1926
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0432	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Echinococcus multilocularis	Smad4	0.0018	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0271	0.0348
Echinococcus multilocularis	dnaJ subfamily B	0.0414	1	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	CXXC zinc finger family protein	0.0059	0.126	0.1614
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0826	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0325	0.7805	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0271	0.139
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0103	0.2331	0.2331
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0271	0.0348
Loa Loa (eye worm)	transcription factor SMAD2	0.027	0.6459	0.8275
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.6603	0.6603
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0263	0.2042
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0986	0.1263
Schistosoma mansoni	intermediate filament proteins	0.0056	0.1189	0.1189
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0263	0.0337
Echinococcus multilocularis	tar DNA binding protein	0.0276	0.6603	0.6603
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0263	0.0263
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.025	0.032
Onchocerca volvulus	Huntingtin homolog	0.0244	0.581	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.0826	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0432	0.0553
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0432	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.0826	0.0826
Loa Loa (eye worm)	MH2 domain-containing protein	0.027	0.6459	0.8275
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0469	0.0601
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0986	0.0986
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0826	0.0826
Schistosoma mansoni	cpg binding protein	0.0063	0.1343	0.1343
Echinococcus granulosus	tar DNA binding protein	0.0276	0.6603	0.6603
Echinococcus granulosus	cpg binding protein	0.0063	0.1343	0.1343
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0103	0.2331	0.2986
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0826	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0543	0.0695
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0432	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0432	0.0553
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.0263
Brugia malayi	hypothetical protein	0.0244	0.581	0.7445
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0325	0.7805	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.025	0.025
Loa Loa (eye worm)	hypothetical protein	0.0244	0.581	0.7445
Trypanosoma brucei	unspecified product	0.0019	0.0263	0.2042
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.6603	0.6603
Loa Loa (eye worm)	RNA binding protein	0.0276	0.6603	0.846
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0432	0.3
Schistosoma mansoni	cpg binding protein	0.0063	0.1343	0.1343
Echinococcus multilocularis	lamin dm0	0.0056	0.1189	0.1189
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0432	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0432	0.0553
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0432	0.3
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Brugia malayi	hypothetical protein	0.0017	0.022	0.0282
Onchocerca volvulus		0.0056	0.1189	0.2046
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.016	0.016
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.0826	0.0826
Loa Loa (eye worm)	Smad1	0.0018	0.0251	0.0322
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0251	0.0251
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.1189	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2331	0.2986
Schistosoma mansoni	lamin	0.0056	0.1189	0.1189
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0251	0.0251
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0271	0.5
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0251	0.0251
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0263	0.0263
Brugia malayi	RNA binding protein	0.0276	0.6603	0.846
Echinococcus granulosus	lamin dm0	0.0056	0.1189	0.1189
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0452	0.4713
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0276	0.6603	0.846
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0263	0.1926
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0826	0.0826
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0452	0.3356
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.016	0.016
Schistosoma mansoni	hypothetical protein	0.0222	0.5271	0.5271
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0432	0.5
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0263	0.0263
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.1189	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0244	0.581	0.7445
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0062
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0337
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0103	0.2331	0.2331
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0325	0.7805	1
Echinococcus granulosus	GPCR family 2	0.0103	0.2331	0.2331
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.6603	0.6603
Schistosoma mansoni	cpg binding protein	0.0059	0.126	0.126
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0543	0.0695
Echinococcus multilocularis	smad	0.0018	0.0251	0.0251
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0337
Echinococcus granulosus	smad	0.0018	0.0251	0.0251
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0826	0.0826
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0432	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.2042
Echinococcus multilocularis	GPCR, family 2	0.0103	0.2331	0.2331
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0432	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.016	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0007	0.0007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0325	0.7805	1
Echinococcus granulosus	lamin	0.0056	0.1189	0.1189
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0112	0.2568	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0443	0.0568
Brugia malayi	MH1 domain containing protein	0.0018	0.0251	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0452	0.0579
Schistosoma mansoni	hypothetical protein	0.0103	0.2331	0.2331
Brugia malayi	latrophilin 2 splice variant baaae	0.0222	0.5271	0.6754
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1163	0.1491
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.016	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0432	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0103	0.2331	0.2331
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0986	0.1263
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.025	0.025
Echinococcus granulosus	Smad4	0.0018	0.0251	0.0251
Brugia malayi	intermediate filament protein	0.0056	0.1189	0.1523
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.6603	0.6603
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0986	0.0986
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0452	1
Echinococcus multilocularis	musashi	0.0056	0.1189	0.1189
Leishmania major	hypothetical protein, conserved	0.0027	0.0452	0.3356
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0432	0.0553
Echinococcus granulosus	intermediate filament protein	0.0056	0.1189	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0443	0.0568
Echinococcus multilocularis	lamin	0.0056	0.1189	0.1189
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0826	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0042	0.0826	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0986	0.0986
Brugia malayi	MH1 domain containing protein	0.001	0.0048	0.0062
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0103	0.2331	0.2331
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0826	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0091	0.0091
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0826	1
Onchocerca volvulus		0.0012	0.0091	0.0157
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0432	0.5
Onchocerca volvulus		0.0056	0.1189	0.2046
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0263	0.0932
Schistosoma mansoni	lamin	0.0056	0.1189	0.1189
Echinococcus granulosus	dna polymerase eta	0.0019	0.0263	0.0263
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0251	0.0322
Onchocerca volvulus		0.0026	0.0432	0.0743
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0452	0.3356
Brugia malayi	MH2 domain containing protein	0.027	0.6459	0.8275
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0452	1
Schistosoma mansoni	hypothetical protein	0.0103	0.2331	0.2331
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0263	0.0932
Loa Loa (eye worm)	TAR-binding protein	0.0276	0.6603	0.846
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0986	0.0986
Schistosoma mansoni	hypothetical protein	0.0103	0.2331	0.2331
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0263	0.0263
Schistosoma mansoni	smad	0.0018	0.0251	0.0251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0432	0.0553
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0251	0.0251
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0251	0.0322
Schistosoma mansoni	Smad4	0.0018	0.0251	0.0251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0986	0.0986
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0251	0.0251
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0826	1
Onchocerca volvulus	Huntingtin homolog	0.0244	0.581	1
Brugia malayi	RNA recognition motif domain containing protein	0.0276	0.6603	0.846
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0986	0.0986
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0432	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0826	0.0826
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0126	0.2899	0.2899
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0432	0.3
Brugia malayi	MH1 domain containing protein	0.0018	0.0251	0.0322
Brugia malayi	MH2 domain containing protein	0.0018	0.0251	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0271	0.0348
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0244	0.0312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.2042
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0271	0.0348
Brugia malayi	hypothetical protein	0.0027	0.0452	0.0579
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0432	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0432	0.3
Echinococcus multilocularis	cpg binding protein	0.0063	0.1343	0.1343
Brugia malayi	MH2 domain containing protein	0.0018	0.0251	0.0322
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.0826	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0469	0.0469
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.0826	0.0826
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0469	0.0469
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.0826	0.0826
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.2042
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0432	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0432	0.3
Loa Loa (eye worm)	nuclear factor I	0.001	0.0048	0.0062
Schistosoma mansoni	hypothetical protein	0.0103	0.2331	0.2331
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0986	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0222	0.5271	0.6754
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.6603	0.6603
Schistosoma mansoni	hypothetical protein	0.0414	1	1
Brugia malayi	MH1 domain containing protein	0.001	0.0048	0.0062
Brugia malayi	Latrophilin receptor protein 2	0.0103	0.2331	0.2986

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 7.43	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL.	18811133
Efficacy (functional)	= 74 %	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay relative to histamine	ChEMBL.	18811133
Ki (binding)	= 8.5	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL.	23668417
Ki (binding)	= 8.7	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL.	No reference
pKb (functional)	= 8.32	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL.	18811133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL493720

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 997617