Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 633 aa | 616 aa | 38.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0127 | 0.5807 | 1 |
Echinococcus multilocularis | geminin | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0127 | 0.5807 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.3064 | 0.5275 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0127 | 0.5807 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0083 | 0.3064 | 0.2488 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.3064 | 0.5275 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.385 | 0.334 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0127 | 0.5807 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.3064 | 0.5275 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0127 | 0.5807 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0127 | 0.5807 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0127 | 0.5807 | 0.5 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0127 | 0.5807 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0127 | 0.5807 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.3064 | 0.5275 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.385 | 0.334 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.385 | 0.334 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0127 | 0.5807 | 0.546 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.385 | 0.334 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Brugia malayi | phosphofructokinase | 0.0127 | 0.5807 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0083 | 0.3064 | 0.2488 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0127 | 0.5807 | 0.546 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 1 | 1 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0127 | 0.5807 | 0.546 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.3064 | 0.2488 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0127 | 0.5807 | 0.5 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0083 | 0.3064 | 0.2488 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.385 | 0.334 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.385 | 0.2866 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | phosphofructokinase | 0.0127 | 0.5807 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.385 | 0.334 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0127 | 0.5807 | 0.546 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0127 | 0.5807 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.5807 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.045 uM | Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in CHO cells by scintillation counter | ChEMBL. | 18752953 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.