Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0518 | 0.0242 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.4076 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.4897 | 0.6521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.4897 | 0.5987 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0851 | 0.0739 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.4897 | 0.6521 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0518 | 0.0559 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.4897 | 0.5987 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0851 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4357 | 0.4709 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.7956 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.4897 | 0.5292 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.4897 | 0.4159 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7332 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0851 | 0.0739 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.4897 | 0.6521 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4024 | 0.4348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.4897 | 0.5987 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3599 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3611 | 0.3902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.4076 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7332 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.4897 | 0.6521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.2 10'-8M | Estrogenic activity in human MCF7 cells assessed as cell proliferation after 6 days by WST8 assay | ChEMBL. | 18760603 |
RBA (binding) | = 0.004 | Displacement of [2,4,6,7-3H]17beta-estradiol from human recombinant ERbeta receptor by liquid scintillation counter relative to 17-beta-estradiol | ChEMBL. | 18760603 |
RBA (binding) | = 0.352 | Displacement of [2,4,6,7-3H]17beta-estradiol from human recombinant ERalpha receptor by liquid scintillation counter relative to 17-beta-estradiol | ChEMBL. | 18760603 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18760603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.