Detailed information for compound 998011

Basic information

Technical information
  • TDR Targets ID: 998011
  • Name: ZINC01293742
  • MW: 338.45 | Formula: C17H14N4S2
  • H donors: 1 H acceptors: 0 LogP: 4.03 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=c1[nH]nc2n1c(nc1c2c2CCCCc2s1)c1ccccc1
  • InChi: 1S/C17H14N4S2/c22-17-20-19-15-13-11-8-4-5-9-12(11)23-16(13)18-14(21(15)17)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H,20,22)
  • InChiKey: PQXOHDIQJFCWFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00536377
  • STOCK2S-98856

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0133 0.1245 0.4913
Loa Loa (eye worm) DR-78 0.0119 0.109 0.4303
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0192 0.9298
Brugia malayi hypothetical protein 0.0119 0.109 0.4303
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0218 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0119 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Schistosoma mansoni hypothetical protein 0.0039 0.023 0.0287
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0119 0.109 0.109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0252 0.2533 0.3154
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0534 0.154
Echinococcus granulosus nuclear receptor nhr 48 0.0119 0.109 0.1357
Brugia malayi ecdysteroid receptor 0.0252 0.2533 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0252 0.2533 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0252 0.2533 0.3154
Echinococcus granulosus cathepsin l1 0.0019 0.0012 0.0015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0012 0.0048
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0192 0.0192
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0133 0.1245 0.4913
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0252 0.2533 0.2533
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0252 0.2533 0.3154
Echinococcus multilocularis thyroid hormone receptor alpha 0.0252 0.2533 0.2533
Brugia malayi Inositol-1 0.0037 0.0206 0.0812
Brugia malayi tailless protein 0.0119 0.109 0.4303
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0359 0.1023
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0359 0.1028
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0359 0.1418
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0133 0.1245 0.155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0252 0.2533 1
Brugia malayi nuclear receptor NHR-88 0.0119 0.109 0.4303
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0119 0.109 0.1357
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.023 0.0909
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0015
Schistosoma mansoni nuclear receptor 0.0119 0.109 0.1357
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0192 0.0239
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0206 0.0256
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0206 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0252 0.2533 1
Schistosoma mansoni coup transcription factor 0.0252 0.2533 0.3154
Onchocerca volvulus Protein ultraspiracle homolog 0.0252 0.2533 1
Brugia malayi steroid hormone receptor 0.0252 0.2533 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0359 1
Brugia malayi orphan nuclear receptor NR2E1 0.0119 0.109 0.4303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0252 0.2533 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0119 0.109 0.4303
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Brugia malayi hypothetical protein 0.0133 0.1245 0.4913
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0359 1
Echinococcus granulosus microtubule associated protein 2 0.0758 0.8032 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0861
Onchocerca volvulus Bile acid receptor homolog 0.0252 0.2533 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.1699 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0206 0.5226
Brugia malayi Nuclear hormone receptor-like 1 0.0252 0.2533 1
Brugia malayi Steroid receptor seven-up type 2 0.0252 0.2533 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0252 0.2533 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0359 0.1028
Brugia malayi hypothetical protein 0.0119 0.109 0.4303
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0359 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0012
Schistosoma mansoni inositol monophosphatase 0.0037 0.0206 0.0256
Leishmania major cathepsin L-like protease 0.0074 0.0604 0.1745
Toxoplasma gondii hypothetical protein 0.0054 0.0383 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0252 0.2533 0.3154
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0206 0.0571
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0252 0.2533 0.3154
Loa Loa (eye worm) nuclear hormone receptor 0.0119 0.109 0.4303
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0119 0.109 0.109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0252 0.2533 0.3154
Loa Loa (eye worm) inositol-1 0.0037 0.0206 0.0812
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0206 0.5578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0252 0.2533 1
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.1245 0.4913
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0308 0.0872
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0252 0.2533 0.2533
Schistosoma mansoni nuclear receptor nhr-48 0.0119 0.109 0.1357
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0209
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Brugia malayi nuclear receptor RXR 0.0119 0.109 0.4303
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0206 0.0042
Brugia malayi Nuclear hormone receptor E75 0.0119 0.109 0.4303
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0119 0.109 0.4303
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0252 0.2533 0.2533
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0218 0.0084
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.3404 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0252 0.2533 1
Schistosoma mansoni retinoic acid receptor RXR 0.0252 0.2533 0.3154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0359 0.1023
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0359 0.1275
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0604 0.1745
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0192 0.0531
Echinococcus multilocularis FTZ F1 alpha 0.0252 0.2533 0.2533
Schistosoma mansoni zinc finger protein 0.0119 0.109 0.1357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0252 0.2533 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0252 0.2533 0.3154
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0133 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0759
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0861
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0252 0.2533 0.3154
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0119 0.109 0.4303
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0206 1
Onchocerca volvulus 0.0119 0.109 0.4276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0252 0.2533 1
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0359 0.1418
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0252 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.1418
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0359 0.1023
Leishmania major cathepsin L-like protease 0.0074 0.0604 0.1745
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0012 0.0015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0192 0.0239
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Leishmania major cathepsin L-like protease 0.0074 0.0604 0.1745
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0012 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0192 0.0239
Schistosoma mansoni nuclear receptor 0.0119 0.109 0.1357
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0429 0.1692
Onchocerca volvulus 0.0051 0.0359 0.1376
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0192 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0119 0.109 0.1357
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0133 0.1245 0.155
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0119 0.109 0.4276
Brugia malayi hypothetical protein 0.0133 0.1245 0.4913
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0252 0.2533 0.3154
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0861
Schistosoma mansoni thyroid hormone receptor 0.0252 0.2533 0.3154
Brugia malayi Nuclear hormone receptor E75 0.0119 0.109 0.4303
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0192 0.0192
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0218 0.0357
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.3404 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0206 0.5
Brugia malayi nuclear receptor RXR 0.0133 0.1245 0.4913
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.1245 0.4913
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0012 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.0252 0.2533 0.3154
Echinococcus granulosus FTZ F1 alpha 0.0252 0.2533 0.3154
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0192 0.0759
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0133 0.1245 0.4913
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0192 0.0239
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0252 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0252 0.2533 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0192 0.0531
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Schistosoma mansoni nuclear hormone receptor 0.0252 0.2533 0.3154
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0308 0.0361
Echinococcus granulosus ecdysone induced protein 78C 0.0252 0.2533 0.3154
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0218 0.5
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0252 0.2533 1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0604 0.1745
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0359 0.1028
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0252 0.2533 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0252 0.2533 0.2533
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0909
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1506 0.4406
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0209
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0252 0.2533 0.3154
Brugia malayi conserved hypotetical protein 0.0119 0.109 0.4303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0308 0.0872
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0252 0.2533 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.3404 1
Loa Loa (eye worm) fibroinase 0.0019 0.0012 0.0048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0252 0.2533 0.3154
Loa Loa (eye worm) hypothetical protein 0.0133 0.1245 0.4913
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0308 0.0872
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0359 0.1028
Onchocerca volvulus 0.0119 0.109 0.4276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0252 0.2533 1
Schistosoma mansoni nuclear hormone receptor 0.0119 0.109 0.1357
Brugia malayi nuclear hormone receptor 0.0119 0.109 0.4303
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0192 0.9298
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0012 0.0048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0861
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0359 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0252 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0119 0.109 0.4276
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0119 0.109 0.109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0252 0.2533 1
Brugia malayi nuclear hormone receptor 0.0252 0.2533 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0359 0.1275
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0192 0.9298
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.8032 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Brugia malayi nuclear hormone receptor family member nhr-6 0.0119 0.109 0.4303
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0359 0.1028
Echinococcus granulosus Nuclear hormone receptor HR96 0.0119 0.109 0.1357
Schistosoma mansoni thyroid hormone receptor 0.0252 0.2533 0.3154
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0429 0.1692
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0419 0.1199
Mycobacterium ulcerans hypothetical protein 0.0051 0.0359 0.1028
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0192 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0252 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0861
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0252 0.2533 1
Schistosoma mansoni nuclear hormone receptor 0.0119 0.109 0.1357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Brugia malayi ecdysone receptor 0.0119 0.109 0.4303
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0192 0.5187
Loa Loa (eye worm) steroid hormone receptor 0.0252 0.2533 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0119 0.109 0.1357
Loa Loa (eye worm) hypothetical protein 0.0119 0.109 0.4303
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0119 0.109 0.1357
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1506 0.4406
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0252 0.2533 0.2533
Loa Loa (eye worm) ctsf protein 0.0019 0.0012 0.0048
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1506 0.4092
Mycobacterium ulcerans hypothetical protein 0.0175 0.1699 1
Loa Loa (eye worm) cysteine protease 0.0019 0.0012 0.0048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0252 0.2533 0.3154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0119 0.109 0.109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0252 0.2533 0.3154
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0218 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0119 0.109 0.109
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0206 0.0571
Loa Loa (eye worm) hypothetical protein 0.0058 0.0429 0.1692
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0252 0.2533 0.2533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Echinococcus granulosus thyroid hormone receptor alpha 0.0119 0.109 0.1357
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0604 0.1745
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.8032 0.8032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0133 0.1245 0.155
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0432 0.1238
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0604 0.1745
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0429 0.1692
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0359 0.1028
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.3404 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0206 0.0256
Echinococcus multilocularis ecdysone induced protein 78C 0.0252 0.2533 0.2533
Brugia malayi nuclear hormone receptor family member odr-7 0.0119 0.109 0.4303
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.1418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0252 0.2533 0.3154
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0359 0.1418
Onchocerca volvulus 0.0252 0.2533 1
Brugia malayi nuclear receptor NHR-88 0.0252 0.2533 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0252 0.2533 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0206 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0252 0.2533 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0604 0.1282
Brugia malayi nuclear receptor NHR-67 0.0119 0.109 0.4303
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0192 0.0531
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0048
Loa Loa (eye worm) hypothetical protein 0.0133 0.1245 0.4913
Echinococcus granulosus Nuclear hormone receptor HR96 0.0119 0.109 0.1357
Loa Loa (eye worm) hypothetical protein 0.0133 0.1245 0.4913

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of rat adenosine A2A receptor upto 1 uM ChEMBL. 17602796
Inhibition (binding) = 0 % Inhibition of rat adenosine A1 receptor at 1 uM ChEMBL. 17602796

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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