Detailed information for compound 998126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.658 | Formula: C18H13BrClNO3
  • H donors: 1 H acceptors: 2 LogP: 5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(cc(c1)C)NC(=O)c1cc2cc(Cl)cc(c2oc1=O)Br
  • InChi: 1S/C18H13BrClNO3/c1-9-3-10(2)5-13(4-9)21-17(22)14-7-11-6-12(20)8-15(19)16(11)24-18(14)23/h3-8H,1-2H3,(H,21,22)
  • InChiKey: NIYAHNDDVVFHBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0518 0.1606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.2977 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0073 0.029 0.029
Schistosoma mansoni alpha-glucosidase 0.0168 0.08 0.08
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.006 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Giardia lamblia Fructose-bisphosphate aldolase 0.0571 0.2977 1
Echinococcus granulosus carbonic anhydrase 0.0229 0.113 0.113
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0038
Toxoplasma gondii hypothetical protein 0.0229 0.113 1
Echinococcus granulosus neuropeptide s receptor 0.0472 0.2439 0.2439
Echinococcus multilocularis neutral amino acid transporter A 0.1873 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0229 0.113 0.113
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0069 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0031 0.006 0.006
Onchocerca volvulus 0.0116 0.0518 0.0485
Trichomonas vaginalis hypothetical protein 0.0033 0.0071 0.0239
Treponema pallidum glutamate transporter 0.083 0.4373 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0127 0.0427
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0127 0.0427
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.006 0.006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0229 0.113 0.113
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.0123 0.0414
Plasmodium falciparum thioredoxin reductase 0.0123 0.0557 0.4927
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.006 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0674 0.2092
Trypanosoma brucei carbonic anhydrase-like protein 0.0617 0.3223 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.0123 0.088
Loa Loa (eye worm) hypothetical protein 0.0229 0.113 0.113
Trichomonas vaginalis rotamase, putative 0.0032 0.0064 0.0216
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0012 0.0108
Entamoeba histolytica Ran family GTPase 0.0022 0.0012 0.0041
Mycobacterium ulcerans beta-lactamase 0.0116 0.0518 0.3698
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0064 0.02
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0334 0.1696 0.1696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.006 0.006
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.0518 0.0518
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.033 0.033
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0176 0.0546
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0617 0.3223 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0153
Echinococcus granulosus lamin dm0 0.0026 0.0034 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0123 0.0557 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.006 0.006
Brugia malayi RNA, U transporter 1 0.0168 0.08 0.08
Schistosoma mansoni aldehyde dehydrogenase 0.0202 0.0982 0.0982
Schistosoma mansoni carbonic anhydrase-related 0.0229 0.113 0.113
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Schistosoma mansoni importin beta-1 0.0059 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Loa Loa (eye worm) glutaminase 0.0269 0.1343 0.1343
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0518 0.1606
Trypanosoma brucei trypanothione reductase 0.0123 0.0557 0.1727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.006 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.0982 0.7016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0202 0.0982 0.0982
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.006 0.006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0279 0.14 0.8875
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.029 0.029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.029 0.029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0157 0.0157
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.0123 0.0107
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.006 0.006
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0258 0.0258
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.006 0.006
Leishmania major GTP-binding protein, putative 0.0022 0.0012 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.006 0.006
Echinococcus multilocularis carbonic anhydrase 0.0229 0.113 0.113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Brugia malayi glutaminase DH11.1 0.0269 0.1343 0.1343
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0202 0.0982 0.0982
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.0518 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.006 0.006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.0123 0.088
Treponema pallidum fructose-bisphosphate aldolase 0.0571 0.2977 0.6808
Onchocerca volvulus 0.0113 0.0503 0.047
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.1543 0.4788
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0762 0.0762
Leishmania major hypothetical protein, conserved 0.0022 0.001 0.0031
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0127 0.1125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0739 0.3882 0.3882
Echinococcus multilocularis carbonic anhydrase II 0.0617 0.3223 0.3223
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.006 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0123 0.0382
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0127 0.0394
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Onchocerca volvulus 0.0052 0.0174 0.014
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0113
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0108
Schistosoma mansoni carbonic anhydrase 0.0229 0.113 0.113
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0152 0.051
Schistosoma mansoni alpha glucosidase 0.0043 0.0127 0.0127
Echinococcus multilocularis snurportin 1 0.0631 0.3298 0.3298
Brugia malayi hypothetical protein 0.0068 0.0258 0.0258
Schistosoma mansoni tsg101-related 0.0056 0.0197 0.0197
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0127 0.0427
Echinococcus multilocularis Excitatory amino acid transporter 0.1873 1 1
Echinococcus granulosus muscleblind protein 0.0334 0.1696 0.1696
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0617 0.3223 0.3223
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0063 0.0063
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.033 0.033
Brugia malayi beta-lactamase family protein 0.0116 0.0518 0.0518
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.0518 0.0518
Plasmodium vivax thioredoxin reductase, putative 0.0123 0.0557 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0312 0.1575 0.1575
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.0123 0.088
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0063 0.0555
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.028 0.1406 0.1406
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.0123 0.109
Schistosoma mansoni carbonic anhydrase-related 0.0229 0.113 0.113
Mycobacterium tuberculosis Probable dehydrogenase 0.028 0.1406 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.006 0.006
Mycobacterium ulcerans glutaminase 0.0269 0.1343 0.9597
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0202 0.0982 0.0982
Loa Loa (eye worm) carbonic anhydrase 3 0.0617 0.3223 0.3223
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.006 0.006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0617 0.3223 0.3223
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.001 0.0031
Brugia malayi glutathione reductase 0.0123 0.0557 0.0557
Brugia malayi Pre-SET motif family protein 0.0219 0.1074 0.1074
Brugia malayi beta-lactamase 0.0116 0.0518 0.0518
Echinococcus granulosus tumor protein p63 0.0355 0.181 0.181
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.006 0.006
Schistosoma mansoni glutaminase 0.0269 0.1343 0.1343
Brugia malayi Thioredoxin reductase 0.0123 0.0557 0.0557
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0064 0.02
Onchocerca volvulus 0.0031 0.006 0.0026
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0016 0.0037
Mycobacterium ulcerans lipase LipD 0.0116 0.0518 0.3698
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.006 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0672 0.0672
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0195 0.0947 0.0947
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.0518 0.0518
Schistosoma mansoni thyroid hormone receptor 0.0031 0.006 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.006 0.006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.006 0.006
Echinococcus granulosus lysosomal alpha glucosidase 0.0195 0.0947 0.0947
Echinococcus multilocularis tumor protein p63 0.0355 0.181 0.181
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.1335 0.1335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Leishmania major hypothetical protein, conserved 0.0116 0.0518 0.1606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0672 0.0672
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.006 0.006
Echinococcus granulosus excitatory amino acid transporter 3 0.1873 1 1
Echinococcus granulosus excitatory amino acid transporter 2 0.1873 1 1
Echinococcus granulosus expressed protein 0.0032 0.0069 0.0069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0056 0.0056
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0212 0.1879
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.006 0.006
Plasmodium falciparum glutathione reductase 0.0043 0.0123 0.109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0127 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0672 0.0672
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0016 0.0114
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0212 0.0212
Echinococcus granulosus snurportin 1 0.0631 0.3298 0.3298
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0113
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0059 0.0212 0.0212
Loa Loa (eye worm) glutaminase 2 0.0269 0.1343 0.1343
Echinococcus granulosus importin subunit beta 1 0.0059 0.0212 0.0212
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0016 0.0016
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0617 0.3223 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0124 0.0562 0.0562
Toxoplasma gondii aldehyde dehydrogenase 0.0202 0.0982 0.8694
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.006 0.006
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0127 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0127 0.0427
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0064 0.02
Trichomonas vaginalis esterase, putative 0.0116 0.0518 0.1739
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0518 0.1606
Plasmodium falciparum glutathione reductase 0.0123 0.0557 0.4927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0229 0.113 0.113
Entamoeba histolytica hypothetical protein 0.0048 0.0152 0.051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0153 0.0153
Echinococcus multilocularis neutral amino acid transporter A 0.1873 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Schistosoma mansoni carbonic anhydrase-related 0.0229 0.113 0.113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.0947 0.0947
Plasmodium falciparum carbonic anhydrase 0.0229 0.113 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0012 0.0218
Echinococcus multilocularis carbonic anhydrase 0.0229 0.113 0.113
Plasmodium falciparum thioredoxin reductase 0.0043 0.0123 0.109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0674 0.2092
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.0123 0.0123
Trichomonas vaginalis ran, putative 0.0022 0.0012 0.0041
Schistosoma mansoni lamin 0.0026 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0073 0.029 0.0974
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0127 0.0427
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.0518 0.0518
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0672 0.0672
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0063 0.0063
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0073 0.029 0.0974
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.006 0.006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.006 0.006
Leishmania major trypanothione reductase 0.0123 0.0557 0.1727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.006 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0127 0.0427
Schistosoma mansoni hypothetical protein 0.0631 0.3298 0.3298
Loa Loa (eye worm) hypothetical protein 0.0068 0.0258 0.0258
Echinococcus granulosus geminin 0.0343 0.1743 0.1743
Echinococcus multilocularis excitatory amino acid transporter 2 0.1873 1 1
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.0123 0.0414
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0312 0.1575 1
Echinococcus multilocularis musashi 0.0026 0.0034 0.0034
Onchocerca volvulus 0.0049 0.0157 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.006 0.006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.0123 0.0382
Trichomonas vaginalis glutaminase, putative 0.0269 0.1343 0.4512
Schistosoma mansoni alpha-glucosidase 0.0168 0.08 0.08
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0617 0.3223 0.3223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0152 0.051
Brugia malayi steroid hormone receptor 0.0031 0.006 0.006
Brugia malayi nuclear receptor NHR-88 0.0031 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.006 0.006
Echinococcus multilocularis muscleblind protein 0.0334 0.1696 0.1696
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.006 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.006 0.006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Schistosoma mansoni tsg101-related 0.0056 0.0197 0.0197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0672 0.0672
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0016 0.005
Plasmodium vivax glutathione reductase, putative 0.0123 0.0557 1
Schistosoma mansoni hypothetical protein 0.0033 0.0071 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0518 0.9299
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0127 0.0427
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.2439 0.2439
Toxoplasma gondii ABC1 family protein 0.0116 0.0518 0.4582
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0071 0.0071
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0518 0.3217
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0034 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.0123 0.2213
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0631 0.3298 0.3298
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Loa Loa (eye worm) glutathione reductase 0.0123 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0672 0.0672
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.006 0.006
Onchocerca volvulus 0.0081 0.033 0.0297
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0062 0.0062
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.0123 0.0123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.0518 0.0518
Mycobacterium leprae Probable lipase LipE 0.0116 0.0518 0.3217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Leishmania major importin beta-1 subunit, putative 0.0048 0.0152 0.0472
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0312 0.1575 0.1575
Echinococcus granulosus excitatory amino acid transporter 2 0.1873 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0071 0.0071
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.0518 0.0518
Echinococcus multilocularis lamin dm0 0.0026 0.0034 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.006 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.006 0.006
Leishmania major carbonic anhydrase-like protein 0.0617 0.3223 1
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.2439 0.2439
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0152 0.051
Echinococcus multilocularis excitatory amino acid transporter 3 0.1873 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.0557 0.1727
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0229 0.113 0.113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.0123 0.0123
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0229 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0229 0.113 0.113
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0016 0.0142
Chlamydia trachomatis glutamate symporter 0.1873 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Echinococcus multilocularis Excitatory amino acid transporter 0.1873 1 1
Mycobacterium tuberculosis Conserved protein 0.0116 0.0518 0.0518
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.033 0.033
Schistosoma mansoni aldehyde dehydrogenase 0.0202 0.0982 0.0982
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0153 0.0153
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.028 0.1406 0.8917
Loa Loa (eye worm) hypothetical protein 0.0334 0.1696 0.1696
Echinococcus multilocularis excitatory amino acid transporter 2 0.1873 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0518 0.0518
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0069 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0124 0.0562 0.0562
Onchocerca volvulus 0.0031 0.0063 0.0029
Loa Loa (eye worm) hypothetical protein 0.0116 0.0518 0.0518
Brugia malayi ecdysteroid receptor 0.0031 0.006 0.006
Echinococcus granulosus Excitatory amino acid transporter 0.1873 1 1
Echinococcus granulosus carbonic anhydrase 0.0229 0.113 0.113
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0012 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0518 0.1739
Echinococcus multilocularis carbonic anhydrase 0.0229 0.113 0.113
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.028 0.1406 0.1406
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0063 0.0063
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1237 0.4154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.006 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.0982 0.7016
Loa Loa (eye worm) hypothetical protein 0.0239 0.1185 0.1185
Brugia malayi hypothetical protein 0.0239 0.1185 0.1185
Schistosoma mansoni intermediate filament proteins 0.0026 0.0034 0.0034
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.0518 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0127 0.0394
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0016 0.0288
Mycobacterium tuberculosis Probable reductase 0.028 0.1406 0.1406
Onchocerca volvulus 0.0116 0.0518 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0127 0.0394
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.006 0.006
Mycobacterium ulcerans hypothetical protein 0.0116 0.0518 0.3698
Schistosoma mansoni rotamase 0.0032 0.0069 0.0069
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.0123 0.0382
Schistosoma mansoni coup transcription factor 0.0031 0.006 0.006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0229 0.113 0.113
Plasmodium falciparum importin beta, putative 0.0059 0.0212 0.1879
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0127 0.0427
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1873 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0518 0.0518
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.0123 0.109
Entamoeba histolytica hypothetical protein 0.0073 0.029 0.0974
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0202 0.0982 0.3047
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0523 0.2718 0.2718
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.006 0.006
Echinococcus multilocularis expressed protein 0.0032 0.0069 0.0069
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0043 0.0123 0.0123
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.0518 0.0518
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0321
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.006 0.006
Loa Loa (eye worm) excitatory amino acid transporter 0.1873 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0518 0.1739
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0518 0.1739
Schistosoma mansoni nuclear hormone receptor 0.0031 0.006 0.006
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0125 0.0389
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0036 0.0652
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0034 0.0034
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0016 0.0114
Onchocerca volvulus 0.0249 0.1237 0.1207
Schistosoma mansoni hypothetical protein 0.0343 0.1743 0.1743
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.006 0.006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0279 0.14 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.006 0.006
Echinococcus granulosus neutral amino acid transporter A 0.1873 1 1
Toxoplasma gondii hypothetical protein 0.0049 0.0159 0.1411
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0123 0.0382
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.083 0.4373 0.4373
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.0123 0.0382
Brugia malayi Muscleblind-like protein 0.0334 0.1696 0.1696
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0038
Schistosoma mansoni hypothetical protein 0.0343 0.1743 0.1743
Giardia lamblia NADH oxidase lateral transfer candidate 0.0043 0.0123 0.0414
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0063 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.028 0.1406 0.1406
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.1543 0.4788
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0127 0.0127
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.006 0.006
Echinococcus granulosus neutral amino acid transporter 0.1873 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0195 0.0947 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0672 0.0672
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0142 0.0475
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1185 0.1185
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0174 0.0174
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0064 0.02
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0012 0.0012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0127 0.0427
Brugia malayi Importin beta-1 subunit 0.0059 0.0212 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0672 0.0672
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.1335 0.1335
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0123 0.0382
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0518 0.3698
Brugia malayi Pre-SET motif family protein 0.0031 0.0063 0.0063
Echinococcus granulosus neutral amino acid transporter A 0.1873 1 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.113 0.113
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1185 0.1185
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.028 0.1406 0.1406
Brugia malayi intermediate filament protein 0.0026 0.0034 0.0034
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.0123 0.109
Schistosoma mansoni thyroid hormone receptor 0.0031 0.006 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.0982 0.7016
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0069 0.023
Plasmodium vivax SET domain protein, putative 0.0031 0.0063 0.1125
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.2439 0.2439
Echinococcus granulosus Excitatory amino acid transporter 0.1873 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.006 0.006
Echinococcus granulosus lamin 0.0026 0.0034 0.0034
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0212 0.0659
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0016 0.0142
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.0123 0.0382
Entamoeba histolytica hypothetical protein 0.0073 0.029 0.0974
Schistosoma mansoni lamin 0.0026 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.006 0.006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.0123 0.109
Treponema pallidum NADH oxidase 0.0043 0.0123 0.0282
Brugia malayi hypothetical protein 0.0026 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0123 0.0123
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0062 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0036 0.0113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0125 0.0389
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.0123 0.2213
Brugia malayi nuclear hormone receptor 0.0031 0.006 0.006
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0617 0.3223 0.3223
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0127 0.0127
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.001 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.0947 0.0947
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0518 0.1739
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.0123 0.0123
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.083 0.4373 0.4373
Echinococcus multilocularis neutral amino acid transporter A 0.1873 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0031
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0064 0.0571
Brugia malayi beta-lactamase family protein 0.0116 0.0518 0.0518
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0258 0.0258
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0152 0.0472
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0034 0.0034
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.033 0.033
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1873 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0123 0.0382
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1873 1 1
Echinococcus multilocularis muscleblind protein 1 0.0334 0.1696 0.1696
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.083 0.4373 0.4373
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.1543 0.4788
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.006 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0672 0.0672
Trichomonas vaginalis rotamase, putative 0.0032 0.0069 0.023
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.006 0.006
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0125 0.0389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0041
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0016 0.0142
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.2977 1
Trypanosoma brucei glucosidase, putative 0.0043 0.0127 0.0394
Schistosoma mansoni survival motor neuron protein 0.0049 0.0157 0.0157
Schistosoma mansoni ran 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1873 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0279 0.14 0.14
Schistosoma mansoni tsg101-related 0.0046 0.0142 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0312 0.1575 0.1575
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.0518 0.0518
Toxoplasma gondii thioredoxin reductase 0.0123 0.0557 0.4927
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0674 0.2092
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0113
Echinococcus multilocularis sodium:dicarboxylate symporter 0.083 0.4373 0.4373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.006 0.006
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1873 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.033 0.033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Loa Loa (eye worm) thioredoxin reductase 0.0123 0.0557 0.0557
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.006 0.006
Brugia malayi MH2 domain containing protein 0.0267 0.1335 0.1335
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0518 0.1739
Echinococcus granulosus intermediate filament protein 0.0026 0.0034 0.0034
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1873 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0063 0.0063
Mycobacterium ulcerans hypothetical protein 0.0161 0.0762 0.5447
Mycobacterium tuberculosis Conserved protein 0.0116 0.0518 0.0518
Echinococcus granulosus carbonic anhydrase II 0.0617 0.3223 0.3223
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0123 0.0382
Brugia malayi follicle stimulating hormone receptor 0.0523 0.2718 0.2718
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0064 0.0216
Echinococcus multilocularis geminin 0.0343 0.1743 0.1743
Loa Loa (eye worm) beta-lactamase 0.0116 0.0518 0.0518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.2977 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0229 0.113 0.113
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.0518 0.3698
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1074 0.1074
Schistosoma mansoni ran 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.0518 0.0518
Plasmodium vivax importin-beta 2, putative 0.0059 0.0212 0.3814
Mycobacterium tuberculosis Conserved protein 0.0116 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.006
Echinococcus granulosus sodium:dicarboxylate symporter 0.1873 1 1
Brugia malayi hypothetical protein 0.0073 0.029 0.029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.006 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.006 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.1543 0.4788
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0016 0.005
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0036 0.0321
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0127 0.0427
Onchocerca volvulus 0.0116 0.0518 0.0485
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0617 0.3223 0.3223
Chlamydia trachomatis neutral amino acid transporter 0.083 0.4373 0.4364
Echinococcus granulosus carbonic anhydrase 0.0229 0.113 0.113
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0123 0.0382
Echinococcus multilocularis lamin 0.0026 0.0034 0.0034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.006 0.006
Treponema pallidum glutamate/aspartate transporter 0.083 0.4373 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.006 0.006
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0212 0.0659
Loa Loa (eye worm) hypothetical protein 0.0052 0.0174 0.0174
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0125 0.0389

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 32 uM Inhibition of human factor 12a ChEMBL. 18459730
IC50 (binding) > 50 uM Inhibition of human thrombin ChEMBL. 18459730
IC50 (binding) > 50 uM Inhibition of human tissue factor/factor 7a ChEMBL. 18459730
IC50 (binding) > 50 uM Inhibition of human kallikrein ChEMBL. 18459730
IC50 (binding) > 50 uM Inhibition of human factor 10a ChEMBL. 18459730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.