Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0057 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0728 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0284 | 0.3392 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0728 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0284 | 0.3392 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0728 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0728 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0728 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0284 | 0.3392 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0284 | 0.3392 | 0.3392 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0728 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0728 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0728 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0728 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0728 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0728 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0284 | 0.3392 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0096 | 0.0594 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0096 | 0.0594 | 0.0594 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0728 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0057 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0728 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0284 | 0.3392 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 140 uM | Induction of human histidine10-tagged MDR1 ATPase activity expressed in BHK cells by apparent Michaelis-Menten constant | ChEMBL. | 19402665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.