Detailed information for compound 998347

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.002 | Formula: C27H33ClO3
  • H donors: 1 H acceptors: 2 LogP: 7.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)COc1cc2c(cc1C(C)C)CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(=O)O
  • InChi: 1S/C27H33ClO3/c1-17(2)21-14-19-8-11-24-26(3,12-5-13-27(24,4)25(29)30)22(19)15-23(21)31-16-18-6-9-20(28)10-7-18/h6-7,9-10,14-15,17,24H,5,8,11-13,16H2,1-4H3,(H,29,30)/t24-,26-,27-/m1/s1
  • InChiKey: FJJQORNJBQDNQF-ZRJLEYOISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.0014 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.001 0.001
Loa Loa (eye worm) peptidase family M1 containing protein 0.0223 0.0457 0.0447
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0145 0.3036
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4195 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0093 0.0145 0.0145
Brugia malayi proteasome subunit beta type 2 0.0039 0.0014 0.003
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.0114 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.001 0.0021
Brugia malayi Bromodomain containing protein 0.0093 0.0145 0.0319
Onchocerca volvulus 0.0057 0.0059 0.0439
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0014 0.0036
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.0193 0.0183
Toxoplasma gondii aminopeptidase n, putative 0.0223 0.0457 1
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.0114 0.2173
Loa Loa (eye worm) PHD-finger family protein 0.0093 0.0145 0.0136
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0014 0.0014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0059 0.0059
Loa Loa (eye worm) serotonin transporter b 0.0337 0.073 0.0722
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0193 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.005 0.0111
Giardia lamblia PHD finger protein 15 0.0093 0.0145 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Onchocerca volvulus 0.0063 0.0072 0.0562
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0487 1
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.0114 0.2254
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0049
Onchocerca volvulus 0.0223 0.0457 0.403
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Brugia malayi beta-lactamase family protein 0.0037 0.001 0.0021
Echinococcus granulosus proteasome prosome macropain 0.008 0.0114 0.0104
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.0114 0.2254
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.0114 0.2323
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0071 0.0549
Echinococcus multilocularis PHD finger protein rhinoceros 0.0093 0.0145 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.0193 0.0183
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.0014 0.0052
Plasmodium vivax amine transporter, putative 0.0057 0.0059 0.1091
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0145 0.3036
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.0014 0.0004
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.016 0.0306 0.0296
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0059 0.0049
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0306 0.0656 0.0647
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0223 0.0457 0.5833
Trypanosoma brucei Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Brugia malayi hypothetical protein 0.0057 0.0059 0.0128
Brugia malayi beta-lactamase family protein 0.0037 0.001 0.0021
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0071 0.432
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0072 0.0062
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0071 0.0061
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.0114 0.2323
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4195 1 1
Trypanosoma brucei aminopeptidase, putative 0.0223 0.0457 0.5833
Toxoplasma gondii aminopeptidase N, putative 0.0223 0.0457 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0193 0.0384 0.0375
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0215 0.0206
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0071 0.0061
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0071 0.1363
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0337 0.073 0.073
Onchocerca volvulus 0.0057 0.0059 0.0439
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0306 0.0656 0.0647
Mycobacterium ulcerans proteasome PrcB 0.008 0.0114 0.2323
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0136
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.0114 1
Plasmodium falciparum phd finger protein, putative 0.0093 0.0145 0.2973
Trypanosoma cruzi aminopeptidase, putative 0.0223 0.0457 0.5833
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Mycobacterium ulcerans aminopeptidase N PepN 0.0223 0.0457 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0071 0.1284
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.0776 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0093 0.0145 0.0145
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Trichomonas vaginalis set domain proteins, putative 0.0498 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Echinococcus granulosus serotonin transporter 0.0337 0.073 0.0721
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0014 0.0036
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0049
Brugia malayi jmjC domain containing protein 0.0113 0.0193 0.0423
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0072 0.0072
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0071 0.0795
Plasmodium falciparum transporter, putative 0.0057 0.0059 0.101
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0071 0.0071
Echinococcus multilocularis aminopeptidase N 0.0223 0.0457 0.0447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0193 0.0193
Echinococcus multilocularis geminin 0.0186 0.0368 0.0359
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0059 0.0059
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.0114 0.0249
Onchocerca volvulus 0.0223 0.0457 0.403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.001 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.005 0.0041
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0223 0.0457 0.5833
Onchocerca volvulus 0.0498 0.1119 1
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0059 0.1091
Toxoplasma gondii aminopeptidase N protein 0.0223 0.0457 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Loa Loa (eye worm) hypothetical protein 0.0063 0.0072 0.0063
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0059 0.0059
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Onchocerca volvulus 0.0223 0.0457 0.403
Brugia malayi MH2 domain containing protein 0.0122 0.0215 0.0472
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.0014 0.0004
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.0776 1
Brugia malayi jmjC domain containing protein 0.0306 0.0656 0.144
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.005 0.0111
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0059 0.0049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0337 0.073 0.0722
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0059 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0067 0.0057
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0223 0.0457 0.0457
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0072 0.0062
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0223 0.0457 0.0447
Echinococcus granulosus jumonji domain containing protein 0.013 0.0233 0.0224
Schistosoma mansoni hypothetical protein 0.0186 0.0368 0.0368
Toxoplasma gondii hypothetical protein 0.0057 0.0059 0.1091
Loa Loa (eye worm) aminopeptidase N 0.0223 0.0457 0.0447
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.0114 0.0104
Onchocerca volvulus Alhambra homolog 0.0093 0.0145 0.1223
Schistosoma mansoni hypothetical protein 0.0037 0.001 0.001
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0071 0.1284
Brugia malayi hypothetical protein 0.0223 0.0457 0.1002
Brugia malayi PHD-finger family protein 0.0093 0.0145 0.0319
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Leishmania major proteasome beta 5 subunit, putative 0.008 0.0114 0.1355
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0114 0.0936
Echinococcus multilocularis jumonji domain containing protein 0.013 0.0233 0.0224
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0223 0.0457 0.5833
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Echinococcus granulosus PHD finger protein rhinoceros 0.0093 0.0145 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0215 0.0206
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0059 0.101
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0059 0.0128
Toxoplasma gondii hypothetical protein 0.0057 0.0059 0.1091
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.0973 0.0965
Brugia malayi TATA binding protein associated factor 0.0223 0.0457 0.1002
Schistosoma mansoni jumonji domain containing protein 0.0243 0.0505 0.0505
Brugia malayi Pre-SET motif family protein 0.0063 0.0072 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Echinococcus granulosus peregrin 0.0093 0.0145 0.0136
Schistosoma mansoni aminopeptidase A (M01 family) 0.0223 0.0457 0.0457
Brugia malayi hypothetical protein 0.1929 0.4555 1
Loa Loa (eye worm) hypothetical protein 0.0356 0.0776 0.0767
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Brugia malayi hypothetical protein 0.0223 0.0457 0.1002
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.0014 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.001 0.0021
Schistosoma mansoni hypothetical protein 0.0186 0.0368 0.0368
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0014 0.0014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0223 0.0457 0.5833
Echinococcus granulosus geminin 0.0186 0.0368 0.0359
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0223 0.0457 0.0457
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Loa Loa (eye worm) hypothetical protein 0.0054 0.005 0.0041
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.0776 0.1703
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Trypanosoma cruzi aminopeptidase, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) TATA binding protein associated factor 0.0223 0.0457 0.0447
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0223 0.0457 0.5833
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.0114 0.0114
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.0776 1
Plasmodium vivax SET domain protein, putative 0.0063 0.0072 0.1394
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0223 0.0457 0.5833
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0145 0.3036
Loa Loa (eye worm) norepinephrine transporter 0.0337 0.073 0.0722
Brugia malayi beta-lactamase 0.0037 0.001 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.0113 0.0193 0.0183
Echinococcus multilocularis peregrin 0.0093 0.0145 0.0136
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0223 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.0014 0.009
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0072 0.0062
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.0014 0.009
Onchocerca volvulus 0.0337 0.073 0.6498
Schistosoma mansoni sodium/chloride dependent transporter 0.0337 0.073 0.073
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0071 0.1363
Trypanosoma cruzi Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Mycobacterium ulcerans aminopeptidase N PepN 0.0223 0.0457 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0337 0.073 0.1603
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0071 0.0061
Treponema pallidum sodium- and chloride- dependent transporter 0.0337 0.073 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 0.0358 0.0349
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0059 0.0049
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.0114 0.7582
Trypanosoma brucei Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0072 0.1394
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.0014 0.0052
Onchocerca volvulus 0.0057 0.0059 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Entamoeba histolytica aminopeptidase, putative 0.0223 0.0457 1
Brugia malayi proteasome subunit beta type 1 0.0062 0.0071 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0223 0.0457 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4195 1 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Brugia malayi Pre-SET motif family protein 0.0438 0.0973 0.2137
Echinococcus multilocularis serotonin transporter 0.0337 0.073 0.0721
Echinococcus granulosus aminopeptidase N 0.0223 0.0457 0.0447

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 91.6 % Channel opening activity at human BKalpha channel expressed in CHOK1 cells assessed as ionic current amplitude at 30 uM at holding potential of -90 mV by population patch clamp technique relative to untreated control ChEMBL. 18789860

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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