Detailed information for compound 998347

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.002 | Formula: C27H33ClO3
  • H donors: 1 H acceptors: 2 LogP: 7.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)COc1cc2c(cc1C(C)C)CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(=O)O
  • InChi: 1S/C27H33ClO3/c1-17(2)21-14-19-8-11-24-26(3,12-5-13-27(24,4)25(29)30)22(19)15-23(21)31-16-18-6-9-20(28)10-7-18/h6-7,9-10,14-15,17,24H,5,8,11-13,16H2,1-4H3,(H,29,30)/t24-,26-,27-/m1/s1
  • InChiKey: FJJQORNJBQDNQF-ZRJLEYOISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0186 0.0368 0.0368
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.0014 0.009
Onchocerca volvulus 0.0057 0.0059 0.0439
Brugia malayi TATA binding protein associated factor 0.0223 0.0457 0.1002
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0059 0.1091
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.0114 0.0104
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.0014 0.009
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Echinococcus multilocularis peregrin 0.0093 0.0145 0.0136
Onchocerca volvulus 0.0223 0.0457 0.403
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0306 0.0656 0.0647
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0223 0.0457 0.0457
Schistosoma mansoni sodium/chloride dependent transporter 0.0337 0.073 0.073
Onchocerca volvulus 0.0057 0.0059 0.0439
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.0114 0.2173
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0059 0.0059
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0014 0.0014
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0059 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Plasmodium vivax amine transporter, putative 0.0057 0.0059 0.1091
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.0014 0.0052
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0223 0.0457 0.5833
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0059 0.0049
Loa Loa (eye worm) peptidase family M1 containing protein 0.0223 0.0457 0.0447
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Trypanosoma brucei aminopeptidase, putative 0.0223 0.0457 0.5833
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0014 0.0014
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0071 0.0061
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Brugia malayi beta-lactamase 0.0037 0.001 0.0021
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0071 0.0549
Echinococcus multilocularis geminin 0.0186 0.0368 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0145 0.3036
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Onchocerca volvulus 0.0498 0.1119 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0193 0.0384 0.0375
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4195 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0059 0.0059
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.0114 0.7582
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0114 0.0936
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0071 0.432
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Loa Loa (eye worm) hypothetical protein 0.0182 0.0358 0.0349
Toxoplasma gondii aminopeptidase N, putative 0.0223 0.0457 1
Echinococcus granulosus jumonji domain containing protein 0.013 0.0233 0.0224
Loa Loa (eye worm) solute carrier family 6 member 4 0.0337 0.073 0.0722
Onchocerca volvulus 0.0223 0.0457 0.403
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0059 0.0049
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.0114 0.0249
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0223 0.0457 0.5833
Trypanosoma cruzi aminopeptidase, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) PHD-finger family protein 0.0093 0.0145 0.0136
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0059 0.0059
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Mycobacterium ulcerans proteasome PrcB 0.008 0.0114 0.2323
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Brugia malayi hypothetical protein 0.1929 0.4555 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.0114 0.0104
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Trypanosoma brucei Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Echinococcus granulosus geminin 0.0186 0.0368 0.0359
Echinococcus multilocularis lysine specific demethylase 5A 0.0113 0.0193 0.0183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.001 0.001
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4195 1 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0071 0.0071
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0215 0.0206
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0071 0.0795
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.0776 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0223 0.0457 0.0457
Toxoplasma gondii aminopeptidase n, putative 0.0223 0.0457 1
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.0014 0.0052
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.0014 0.0052
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.0193 0.0183
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0071 0.1363
Plasmodium falciparum phd finger protein, putative 0.0093 0.0145 0.2973
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Schistosoma mansoni hypothetical protein 0.0186 0.0368 0.0368
Echinococcus granulosus proteasome prosome macropain 0.008 0.0114 0.0104
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4195 1 1
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.0114 0.2254
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0215 0.0206
Echinococcus granulosus peregrin 0.0093 0.0145 0.0136
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0049
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.0014 0.0052
Brugia malayi Pre-SET motif family protein 0.0438 0.0973 0.2137
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0337 0.073 0.073
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.0114 0.2254
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Brugia malayi proteasome subunit beta type 2 0.0039 0.0014 0.003
Trypanosoma brucei Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.0973 0.0965
Onchocerca volvulus 0.0223 0.0457 0.403
Loa Loa (eye worm) hypothetical protein 0.016 0.0306 0.0296
Schistosoma mansoni hypothetical protein 0.0093 0.0145 0.0145
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Onchocerca volvulus Alhambra homolog 0.0093 0.0145 0.1223
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0059 0.0128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0057 0.0059 0.1091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0193 0.0193
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0072 0.0072
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0071 0.0061
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0223 0.0457 0.0447
Brugia malayi MH2 domain containing protein 0.0122 0.0215 0.0472
Trichomonas vaginalis set domain proteins, putative 0.0498 0.1119 1
Toxoplasma gondii aminopeptidase N protein 0.0223 0.0457 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.0014 0.0004
Brugia malayi Bromodomain containing protein 0.0093 0.0145 0.0319
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.0114 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0223 0.0457 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0223 0.0457 0.5833
Toxoplasma gondii hypothetical protein 0.0057 0.0059 0.1091
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.0114 0.2323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0193 0.0193
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Onchocerca volvulus 0.0057 0.0059 0.0439
Loa Loa (eye worm) hypothetical protein 0.0054 0.005 0.0041
Loa Loa (eye worm) norepinephrine transporter 0.0337 0.073 0.0722
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0072 0.0062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0306 0.0656 0.0647
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Onchocerca volvulus 0.0063 0.0072 0.0562
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.0193 0.0183
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0145 0.3036
Loa Loa (eye worm) hypothetical protein 0.0063 0.0072 0.0063
Plasmodium falciparum transporter, putative 0.0057 0.0059 0.101
Brugia malayi hypothetical protein 0.0057 0.0059 0.0128
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0114 0.1355
Loa Loa (eye worm) hypothetical protein 0.0356 0.0776 0.0767
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0014 0.0036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0487 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0337 0.073 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Brugia malayi hypothetical protein 0.0223 0.0457 0.1002
Entamoeba histolytica aminopeptidase, putative 0.0223 0.0457 1
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.0014 0.0004
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Brugia malayi jmjC domain containing protein 0.0113 0.0193 0.0423
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0071 0.0061
Brugia malayi Pre-SET motif family protein 0.0063 0.0072 0.0158
Echinococcus granulosus aminopeptidase N 0.0223 0.0457 0.0447
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0059 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0337 0.073 0.1603
Schistosoma mansoni aminopeptidase A (M01 family) 0.0223 0.0457 0.0457
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0093 0.0145 0.0145
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.0014 0.0004
Brugia malayi beta-lactamase family protein 0.0037 0.001 0.0021
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Giardia lamblia PHD finger protein 15 0.0093 0.0145 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0337 0.073 0.0722
Schistosoma mansoni jumonji domain containing protein 0.0243 0.0505 0.0505
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.005 0.0111
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Echinococcus multilocularis serotonin transporter 0.0337 0.073 0.0721
Echinococcus multilocularis PHD finger protein rhinoceros 0.0093 0.0145 0.0136
Plasmodium vivax SET domain protein, putative 0.0063 0.0072 0.1394
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0223 0.0457 0.5833
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0059 0.101
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Trypanosoma cruzi Aminopeptidase M1, putative 0.0223 0.0457 0.5833
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0145 0.3036
Loa Loa (eye worm) hypothetical protein 0.0223 0.0457 0.0447
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.0128
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0223 0.0457 0.0457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.001 0.0021
Echinococcus multilocularis jumonji domain containing protein 0.013 0.0233 0.0224
Brugia malayi beta-lactamase family protein 0.0037 0.001 0.0021
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.0776 0.1703
Echinococcus granulosus PHD finger protein rhinoceros 0.0093 0.0145 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0072 0.0062
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0059 0.0049
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0072 0.0062
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.0776 1
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0071 0.0795
Loa Loa (eye worm) aminopeptidase N 0.0223 0.0457 0.0447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0067 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.001 0.0021
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Loa Loa (eye worm) serotonin transporter b 0.0337 0.073 0.0722
Onchocerca volvulus 0.0337 0.073 0.6498
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.0114 0.0114
Brugia malayi PHD-finger family protein 0.0093 0.0145 0.0319
Brugia malayi proteasome subunit beta type 1 0.0062 0.0071 0.0155
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0059 0.0049
Brugia malayi hypothetical protein 0.0223 0.0457 0.1002
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0223 0.0457 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.005 0.0041
Brugia malayi jmjC domain containing protein 0.0306 0.0656 0.144
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.0776 1
Trypanosoma cruzi aminopeptidase, putative 0.0223 0.0457 0.5833
Loa Loa (eye worm) TATA binding protein associated factor 0.0223 0.0457 0.0447
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0059 0.0059
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0071 0.1284
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0059 0.1091
Echinococcus multilocularis aminopeptidase N 0.0223 0.0457 0.0447
Leishmania major proteasome beta 5 subunit, putative 0.008 0.0114 0.1355
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0223 0.0457 0.5833
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0223 0.0457 0.403
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.005 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0072 0.0072
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0071 0.1284
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0072 0.1394
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0071 0.1363
Mycobacterium ulcerans aminopeptidase N PepN 0.0223 0.0457 1
Brugia malayi Peptidase family M1 containing protein 0.0223 0.0457 0.1002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0059 0.0059
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0223 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.0093 0.0145 0.0136
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0059 0.0049
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0223 0.0457 0.0447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0059 0.0049
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.0114 0.2323
Schistosoma mansoni hypothetical protein 0.0037 0.001 0.001
Echinococcus granulosus serotonin transporter 0.0337 0.073 0.0721

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 91.6 % Channel opening activity at human BKalpha channel expressed in CHOK1 cells assessed as ionic current amplitude at 30 uM at holding potential of -90 mV by population patch clamp technique relative to untreated control ChEMBL. 18789860

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.