Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0784 | 0.0784 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2438 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0784 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0061 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0061 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.2438 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0129 | 0.0129 |
Onchocerca volvulus | 0.0061 | 1 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0061 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0784 | 0.0784 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0784 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.9742 | 0.9742 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.2438 | 1 |
Echinococcus multilocularis | musashi | 0.0061 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 1 | 0.5 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0029 | 0.2717 | 0.2717 |
Loa Loa (eye worm) | intermediate filament protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0029 | 0.2717 | 0.2717 |
Echinococcus granulosus | lamin | 0.0061 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0784 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0784 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0784 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0784 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.2438 | 0.2438 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2459 | 0.2459 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.8808 | 0.8808 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.8808 | 0.8808 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2438 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0784 | 0.0784 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.4731 | 0.4731 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0784 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.3464 | 0.3464 |
Echinococcus multilocularis | lamin | 0.0061 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0061 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.2438 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0784 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4731 | 0.4731 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2438 | 0.2438 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2717 | 0.2717 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0784 | 0.0784 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0784 | 0.0784 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.2438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2459 | 0.2459 |
Echinococcus multilocularis | lamin dm0 | 0.0061 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2438 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.3464 | 0.3464 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0784 | 0.0784 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4731 | 0.4731 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 3 nM | Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay | ChEMBL. | 19456097 |
Ki (binding) | = 2 nM | Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting | ChEMBL. | 19456097 |
Ki (binding) | = 3 nM | Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting | ChEMBL. | 19456097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.