Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.00302829 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.00302829 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.00302829 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.00302829 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00302829 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.00302829 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00302829 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.00244408 | 0.646196 | 0.646196 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.00244408 | 0.646196 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.00302829 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.00244408 | 0.646196 | 0.59694 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.00157886 | 0.122205 | 0.122205 |
Giardia lamblia | Hypothetical protein | 0.0022423 | 0.523991 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.00244408 | 0.646196 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.00244408 | 0.646196 | 0.59694 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.00244408 | 0.646196 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.00244408 | 0.646196 | 0.59694 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0022423 | 0.523991 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00302829 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.00244408 | 0.646196 | 0.5 |
Onchocerca volvulus | 0.00302829 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.00244408 | 0.646196 | 0.59694 |
Trichomonas vaginalis | sulfite reductase, putative | 0.00244408 | 0.646196 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00244408 | 0.646196 | 0.59694 |
Echinococcus granulosus | peroxidasin | 0.00302829 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Onchocerca volvulus | 0.00302829 | 1 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.00302829 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00302829 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.00244408 | 0.646196 | 0.59694 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.00244408 | 0.646196 | 0.5 |
Brugia malayi | Peroxidasin | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.00244408 | 0.646196 | 0.59694 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.00302829 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00302829 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.00244408 | 0.646196 | 0.59694 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.00244408 | 0.646196 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.00302829 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.00244408 | 0.646196 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.00157886 | 0.122205 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00244408 | 0.646196 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00302829 | 1 | 1 |
Onchocerca volvulus | 0.00302829 | 1 | 0.5 | |
Brugia malayi | hypothetical protein | 0.00302829 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 510 nM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes in mouse 3T3 cells by beta-galactosidase reporter gene assay | ChEMBL. | 19463001 |
EC50 (ADMET) | > 1000 nM | Toxicity against mouse 3T3 cells by resazurin assay | ChEMBL. | 19463001 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 19463001 | |
Mus musculus | ChEMBL23 | 19463001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.