Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.009 | 0.0764 | 0.1219 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0231 | 0.6265 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.031 | 0.9335 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0231 | 0.6265 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.031 | 0.9335 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.031 | 0.9335 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.1425 | 0.1425 |
Schistosoma mansoni | dihydrofolate reductase | 0.009 | 0.0764 | 0.1308 |
Chlamydia trachomatis | dihydrofolate reductase | 0.009 | 0.0764 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.031 | 0.9335 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.031 | 0.9335 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.009 | 0.0764 | 0.0764 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0145 | 0.2904 | 0.389 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.244 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.2275 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.031 | 0.9335 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0231 | 0.6265 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.009 | 0.0764 | 0.0764 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.1425 | 0.0099 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0105 | 0.1346 | 0.1148 |
Onchocerca volvulus | 0.022 | 0.584 | 0.5 | |
Echinococcus multilocularis | thymidylate synthase | 0.022 | 0.584 | 0.584 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.1425 | 0.1425 |
Echinococcus granulosus | thymidylate synthase | 0.022 | 0.584 | 0.584 |
Loa Loa (eye worm) | phosphofructokinase | 0.0107 | 0.1425 | 0.1202 |
Loa Loa (eye worm) | thymidylate synthase | 0.022 | 0.584 | 0.9228 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.022 | 0.584 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.1425 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.1202 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.244 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0145 | 0.2904 | 0.4635 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.2275 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1346 | 0.2149 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.022 | 0.584 | 1 |
Brugia malayi | thymidylate synthase | 0.022 | 0.584 | 0.9322 |
Brugia malayi | Dihydrofolate reductase | 0.009 | 0.0764 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2904 | 0.389 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Brugia malayi | phosphofructokinase | 0.0107 | 0.1425 | 0.2275 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.1202 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.022 | 0.584 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.1121 | 0.1919 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0099 | 0.1121 | 0.1789 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0145 | 0.2904 | 0.4635 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1121 | 0.0649 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.022 | 0.584 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.1425 | 0.1303 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0107 | 0.1425 | 0.1303 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.1425 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.1425 | 0.1303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.03 ug ml-1 | Antitumor activity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 20599299 |
IC50 (functional) | = 9.66 ug ml-1 | Antitumor activity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 20599299 |
IC50 (functional) | = 23.9 ug ml-1 | Antitumor activity against human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 20599299 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20599299 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.