Detailed information for compound 999096

Basic information

Technical information
  • TDR Targets ID: 999096
  • Name: 3-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol- 5-yl]-1-(2-morpholin-4-ylethyl)indole
  • MW: 467.358 | Formula: C23H23BrN4O2
  • H donors: 0 H acceptors: 2 LogP: 4.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)Cc1noc(n1)c1cn(c2c1cccc2)CCN1CCOCC1
  • InChi: 1S/C23H23BrN4O2/c24-18-7-5-17(6-8-18)15-22-25-23(30-26-22)20-16-28(21-4-2-1-3-19(20)21)10-9-27-11-13-29-14-12-27/h1-8,16H,9-15H2
  • InChiKey: CDLABKJCYUMROI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol-5-yl]-1-(2-morpholinoethyl)indole
  • 3-[3-(4-bromobenzyl)-1,2,4-oxadiazol-5-yl]-1-(2-morpholinoethyl)indole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0019 0.0088 0.0312
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0451 0.0451
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.007 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.002 0.0099 0.0099
Echinococcus multilocularis heat shock protein 0.0039 0.0275 0.0275
Onchocerca volvulus Huntingtin homolog 0.0146 0.1281 0.4471
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.007 0.0567 0.0853
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0327
Echinococcus granulosus Nuclear hormone receptor HR96 0.0062 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0433 0.16
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0186 0.0689
Schistosoma mansoni nuclear receptor 0.0062 0.0497 0.0497
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0058 0.0216
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0506 0.0506
Onchocerca volvulus 0.0032 0.0213 0.0742
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0045 0.0331 0.0331
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0182 0.0675
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0251 0.0927
Leishmania major hypothetical protein, conserved 0.0056 0.0433 0.1587
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0663 0.245
Echinococcus granulosus tar DNA binding protein 0.0715 0.6655 0.6655
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0552 0.5111 0.7681
Mycobacterium ulcerans heat shock protein 90 0.0031 0.02 0.0834
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0129
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Trypanosoma brucei unspecified product 0.0013 0.0032 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0924 0.1389
Echinococcus multilocularis tar DNA binding protein 0.0715 0.6655 0.6655
Giardia lamblia DINP protein human, muc B family 0.0019 0.0088 0.196
Echinococcus granulosus transcription factor btf3 0.0296 0.2704 0.2704
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0182 0.0675
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Schistosoma mansoni transcription factor LCR-F1 0.0189 0.1695 0.1695
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0133 0.0493
Brugia malayi hypothetical protein 0.007 0.0567 0.0853
Onchocerca volvulus Bile acid receptor homolog 0.0132 0.1156 0.4036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0174 0.0425
Schistosoma mansoni endoplasmin 0.0039 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0132 0.1156 0.1738
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0088 0.0088
Schistosoma mansoni smad1 5 8 and 0.0034 0.0229 0.0229
Echinococcus multilocularis lamin 0.0032 0.0213 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0132 0.1156 0.1738
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1523 0.2289
Echinococcus granulosus lamin dm0 0.0032 0.0213 0.0213
Trypanosoma brucei protein kinase, putative 0.0058 0.0451 0.1667
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.0058 0.0216
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0244 0.0244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0425 0.157
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0132 0.1156 0.1156
Brugia malayi nuclear receptor NHR-88 0.0132 0.1156 0.1738
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0743 0.0743
Schistosoma mansoni lamin 0.0032 0.0213 0.0213
Entamoeba histolytica hypothetical protein 0.0189 0.1695 0.6268
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.02 0.02
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0088 0.0327
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0663 0.245
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0251 0.0377
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0853
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0275 0.1018
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0924 0.1389
Trypanosoma brucei transcription factor BTF3, putative 0.0296 0.2704 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0174 0.0723
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0251 0.0251
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0229 0.0229
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0451 0.1667
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Brugia malayi intracellular kinase 0.0058 0.0451 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0132 0.1156 0.1738
Trypanosoma cruzi heat shock protein, putative 0.0016 0.0058 0.0216
Echinococcus granulosus cpg binding protein 0.003 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.2704 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0045 0.0331 0.1378
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0433 0.16
Brugia malayi MH2 domain containing protein 0.0034 0.0229 0.0344
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0062 0.0497 0.0747
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0074
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0275 0.1018
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.02 0.605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0174 0.0425
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.02 0.0741
Mycobacterium ulcerans beta-lactamase 0.0036 0.0251 0.1043
Treponema pallidum exodeoxyribonuclease (exoA) 0.0045 0.0331 0.3584
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0251 0.0927
Brugia malayi photoreceptor-specific nuclear receptor 0.0132 0.1156 0.1738
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0663 0.245
Schistosoma mansoni hypothetical protein 0.107 1 1
Loa Loa (eye worm) nuclear factor I 0.0019 0.0086 0.0129
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0182 0.0675
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Entamoeba histolytica hypothetical protein 0.0189 0.1695 0.6268
Echinococcus multilocularis survival motor neuron protein 1 0.0281 0.2559 0.2559
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0158 0.1394 0.2094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Loa Loa (eye worm) hypothetical protein 0.0056 0.0433 0.065
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0331 0.1225
Loa Loa (eye worm) hypothetical protein 0.0552 0.5111 0.7681
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0213 0.032
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0275 0.1018
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0433 0.16
Brugia malayi MH2 domain containing protein 0.0015 0.0052 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.0186 0.028
Brugia malayi nuclear hormone receptor family member odr-7 0.0062 0.0497 0.0747
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0723
Echinococcus multilocularis heat shock protein 90 0.0039 0.0275 0.0275
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0088 0.0368
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.02 0.0558
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.0058 0.0216
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0656 0.0985
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0275 0.1018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0743 0.0743
Schistosoma mansoni lamin 0.0032 0.0213 0.0213
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0058 0.0216
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0132 0.1156 0.1156
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.038 0.3496 0.3496
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Brugia malayi hypothetical protein 0.0062 0.0497 0.0747
Loa Loa (eye worm) hypothetical protein 0.0171 0.1523 0.2289
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Schistosoma mansoni ap endonuclease 0.0045 0.0331 0.0331
Brugia malayi hypothetical protein 0.0189 0.1695 0.2547
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0182 0.4048
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0715 0.6655 0.6655
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Brugia malayi beta-lactamase 0.0036 0.0251 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0743 0.0743
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0088 0.0327
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0812 0.0812
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.012
Loa Loa (eye worm) nuclear receptor NHR-67 0.0062 0.0497 0.0747
Mycobacterium leprae Probable lipase LipE 0.0036 0.0251 0.2712
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0052 0.0077
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0088 0.0327
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0663 0.0663
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0628
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0663 0.245
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0174 0.188
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Onchocerca volvulus Huntingtin homolog 0.0146 0.1281 0.4471
Loa Loa (eye worm) DR-78 0.0062 0.0497 0.0747
Echinococcus multilocularis dna polymerase eta 0.0019 0.0088 0.0088
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0275 0.1018
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0058 0.0058
Brugia malayi nuclear hormone receptor 0.0132 0.1156 0.1738
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0251 0.0927
Brugia malayi ecdysone receptor 0.0062 0.0497 0.0747
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0213 0.032
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0158 0.1394 0.5154
Brugia malayi intermediate filament protein 0.0032 0.0213 0.032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0132 0.1156 0.1156
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0924 0.3418
Trichomonas vaginalis glutaminase, putative 0.0265 0.2403 0.8888
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Brugia malayi beta-lactamase family protein 0.0036 0.0251 0.0377
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0715 0.6655 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0158 0.1394 0.1394
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.012
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0924 0.3418
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0251 0.0251
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0132 0.1156 0.4036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.038 0.3496 0.3496
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0229 0.0229
Loa Loa (eye worm) glutaminase 0.0265 0.2403 0.3611
Echinococcus granulosus transcription factor Dp 1 0.0091 0.0768 0.0768
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0158 0.1394 0.5147
Schistosoma mansoni tar DNA-binding protein 0.0715 0.6655 0.6655
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0812 0.0812
Loa Loa (eye worm) TAR-binding protein 0.0715 0.6655 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.012
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0052 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0251 0.0927
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0088 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0132 0.1156 0.1156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0924 0.3418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Onchocerca volvulus 0.0028 0.0174 0.0606
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0663 0.0663
Echinococcus multilocularis cpg binding protein 0.003 0.0191 0.0191
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0158 0.1394 0.5154
Entamoeba histolytica hypothetical protein 0.0189 0.1695 0.6268
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0062 0.0497 0.1734
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0158 0.1394 0.2094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0132 0.1156 0.1738
Plasmodium vivax heat shock protein 90, putative 0.0016 0.0058 0.0216
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Echinococcus granulosus endoplasmin 0.0031 0.02 0.02
Echinococcus granulosus nuclear receptor nhr 48 0.0062 0.0497 0.0497
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0924 1
Echinococcus multilocularis geminin 0.107 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0924 0.3418
Echinococcus multilocularis Smad4 0.0034 0.0229 0.0229
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0451 0.0451
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0229 0.0344
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0924 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0251 0.0927
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0132 0.1156 0.1738
Loa Loa (eye worm) endoplasmin 0.0039 0.0275 0.0414
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0275 0.1018
Echinococcus multilocularis transcription factor btf3 0.0296 0.2704 0.2704
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0251 0.0808
Mycobacterium tuberculosis Conserved protein 0.0036 0.0251 0.0808
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0924 0.416
Loa Loa (eye worm) nuclear hormone receptor 0.0062 0.0497 0.0747
Brugia malayi Isocitrate dehydrogenase 0.008 0.0663 0.0996
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0924 0.3418
Entamoeba histolytica transcription factor BTF3, putative 0.0296 0.2704 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0251 0.1043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0132 0.1156 0.1738
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.02 0.0741
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0327
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0244 0.0367
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0174 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0132 0.1156 0.1738
Schistosoma mansoni hypothetical protein 0.0171 0.1523 0.1523
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0331 0.1225
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0132 0.1156 0.1156
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0088 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Brugia malayi hypothetical protein 0.0062 0.0497 0.0747
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0251 0.0808
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0251 0.0927
Loa Loa (eye worm) ICD-1 protein 0.0296 0.2704 0.4063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0107 0.0443
Brugia malayi steroid hormone receptor 0.0132 0.1156 0.1738
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0132 0.1156 0.1738
Onchocerca volvulus 0.0057 0.0449 0.1566
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.007 0.0567 0.0567
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0096 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0853
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0052 0.018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.1156 0.1156
Brugia malayi nuclear hormone receptor 0.0062 0.0497 0.0747
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0096 0.0812 0.122
Schistosoma mansoni nuclear receptor nhr-48 0.0062 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0853
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0451 0.0451
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0182 0.0675
Echinococcus granulosus heat shock protein 90 0.0039 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0132 0.1156 0.1738
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0743 0.0743
Schistosoma mansoni hypothetical protein 0.107 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0853
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0451 0.0678
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0186 0.0186
Onchocerca volvulus 0.0036 0.0251 0.0875
Schistosoma mansoni tar DNA-binding protein 0.0715 0.6655 0.6655
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.016
Schistosoma mansoni zinc finger protein 0.0062 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0924 0.0924
Schistosoma mansoni RAR-like nuclear receptor 0.0132 0.1156 0.1156
Schistosoma mansoni glutaminase 0.0265 0.2403 0.2403
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0327
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0663 0.2858
Echinococcus multilocularis ecdysone induced protein 78C 0.0132 0.1156 0.1156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0096 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0251 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0132 0.1156 0.1738
Schistosoma mansoni tar DNA-binding protein 0.0715 0.6655 0.6655
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0251 0.0808
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0045 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0367
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0062 0.0497 0.0497
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0132 0.1156 0.1156
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0663 0.0663
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0058 0.0088
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0088 0.0133
Brugia malayi hypothetical protein 0.0314 0.2865 0.4306
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0058 0.0216
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0449 0.0674
Toxoplasma gondii ABC1 family protein 0.0036 0.0251 0.0927
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0663 0.245
Loa Loa (eye worm) steroid hormone receptor 0.0132 0.1156 0.1738
Echinococcus granulosus survival motor neuron protein 1 0.0281 0.2559 0.2559
Schistosoma mansoni nuclear receptor 0.0062 0.0497 0.0497
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0182 0.0675
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0663 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0132 0.1156 0.1738
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0182 0.0675
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0451 0.1667
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0107 0.009
Loa Loa (eye worm) hypothetical protein 0.0146 0.1281 0.1925
Echinococcus multilocularis heat shock protein 90 0.0031 0.02 0.02
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0158 0.1394 0.1394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0186 0.0186
Trypanosoma brucei RNA helicase, putative 0.01 0.0851 0.3147
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0663 0.245
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0175 0.0263
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0275 0.1018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0189 0.1695 0.1695
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.2704 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0045 0.0331 0.1225
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0132 0.1156 0.1738
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0071 0.0107
Brugia malayi hypothetical protein 0.0146 0.1281 0.1925
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0132 0.1156 0.1156
Brugia malayi nuclear receptor NHR-67 0.0062 0.0497 0.0747
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0133 0.0493
Schistosoma mansoni hypothetical protein 0.0079 0.0656 0.0656
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0663 0.0663
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Plasmodium falciparum heat shock protein 90 0.0039 0.0275 0.1018
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0451 1
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0275 0.1018
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0107 0.0394
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0261
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0451 0.1667
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0331 0.1225
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0174 0.0642
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0311
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0158 0.1394 0.5154
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0088 0.0368
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0275 0.1018
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0191
Schistosoma mansoni smad1 5 8 and 0.0034 0.0229 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0189 0.1695 0.1695
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0451 0.1667
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0062 0.0497 0.0747
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0275 0.1018
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0663 0.245
Schistosoma mansoni Smad4 0.0034 0.0229 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0497 0.0497
Loa Loa (eye worm) Smad1 0.0034 0.0229 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0132 0.1156 0.1738
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0125 0.0461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0743 0.1116
Loa Loa (eye worm) hypothetical protein 0.0146 0.1281 0.1925
Brugia malayi ecdysteroid receptor 0.0132 0.1156 0.1738
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0186 0.0186
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0045 0.0331 0.1211
Brugia malayi Nuclear hormone receptor-like 1 0.0132 0.1156 0.1738
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0251 0.0808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0743 0.0743
Onchocerca volvulus 0.0314 0.2865 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0088 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.2271 0.3413
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0663 0.2438
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0186 0.0186
Echinococcus granulosus heat shock protein 90 0.0031 0.02 0.02
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0045 0.0331 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Echinococcus granulosus ecdysone induced protein 78C 0.0132 0.1156 0.1156
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0062 0.0497 0.0497
Brugia malayi phosphofructokinase 0.0108 0.0924 0.1389
Leishmania major hypothetical protein, conserved 0.0036 0.0251 0.0913
Schistosoma mansoni survival motor neuron protein 0.0057 0.0449 0.0449
Plasmodium vivax basic transcription factor 3b, putative 0.0296 0.2704 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0261
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0782 0.0782
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0096 0.0036
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0782 0.0782
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0663 0.0663
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0275 0.0414
Plasmodium vivax SET domain protein, putative 0.003 0.0186 0.0689
Brugia malayi Nuclear hormone receptor E75 0.0062 0.0497 0.0747
Echinococcus multilocularis lamin dm0 0.0032 0.0213 0.0213
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0107 0.0394
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0924 0.3846
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0743 0.0743
Toxoplasma gondii NAC domain-containing protein 0.0296 0.2704 1
Brugia malayi TAR-binding protein 0.0715 0.6655 1
Echinococcus granulosus FTZ F1 alpha 0.0132 0.1156 0.1156
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0628
Echinococcus multilocularis smad 0.0034 0.0229 0.0229
Schistosoma mansoni Smad4 0.0015 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1813 0.2725
Schistosoma mansoni cpg binding protein 0.0028 0.0175 0.0175
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0062 0.0497 0.0497
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Treponema pallidum heat shock protein 90 0.0031 0.02 0.2168
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0071 0.0107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0182 0.1975
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Brugia malayi tailless protein 0.0062 0.0497 0.0747
Brugia malayi exodeoxyribonuclease III family protein 0.0045 0.0331 0.0498
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2098 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0052 0.0052
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0058 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0052 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0497 0.0497
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0656 0.0985
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0132 0.1156 0.1738
Brugia malayi conserved hypotetical protein 0.0062 0.0497 0.0747
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0451 0.1667
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0088 0.0133
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0656 0.0985
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0275 0.1018
Schistosoma mansoni ap endonuclease 0.0045 0.0331 0.0331
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Entamoeba histolytica protein kinase, putative 0.0058 0.0451 0.1667
Schistosoma mansoni hypothetical protein 0.0025 0.0143 0.0143
Onchocerca volvulus 0.0036 0.0251 0.0875
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0132 0.1156 0.1156
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0132 0.1156 0.1156
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0628
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0174 0.0723
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0058 0.0216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0261
Onchocerca volvulus Protein ultraspiracle homolog 0.0132 0.1156 0.4036
Onchocerca volvulus 0.0058 0.0451 0.1573
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0062 0.0497 0.1734
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.02 0.0727
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0132 0.1156 0.1156
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0261
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.0985
Mycobacterium ulcerans glutaminase 0.0265 0.2403 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0656 0.0656
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0132 0.1156 0.1156
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0045 0.0331 0.7347
Mycobacterium ulcerans lipase LipD 0.0036 0.0251 0.1043
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0182 0.0675
Onchocerca volvulus 0.023 0.2076 0.7244
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0663 0.245
Schistosoma mansoni retinoic acid receptor RXR 0.0132 0.1156 0.1156
Brugia malayi MH1 domain containing protein 0.0034 0.0229 0.0344
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0663 0.0663
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0088 0.0088
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0812 0.0812
Onchocerca volvulus 0.003 0.0186 0.065
Schistosoma mansoni endoplasmin 0.0039 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.007 0.0567 0.0567
Echinococcus granulosus smad 0.0034 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0314 0.2865 0.4306
Echinococcus granulosus GPCR family 2 0.0079 0.0656 0.0656
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0275 0.1018
Schistosoma mansoni hypothetical protein 0.0057 0.0449 0.0449
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0663 0.0996
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0451 0.1667
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1156 0.1156
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0506 0.0506
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0062 0.0497 0.0497
Echinococcus granulosus dna polymerase kappa 0.0019 0.0088 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0132 0.1156 0.1156
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0715 0.6655 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0182 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0174 0.188
Brugia malayi Nuclear hormone receptor E75 0.0062 0.0497 0.0747
Trichomonas vaginalis esterase, putative 0.0036 0.0251 0.0927
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Echinococcus granulosus Nuclear hormone receptor HR96 0.0062 0.0497 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0723
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0451 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0251 0.1043
Brugia malayi beta-NAC-like protein 0.0296 0.2704 0.4063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Schistosoma mansoni hypothetical protein 0.0079 0.0656 0.0656
Brugia malayi nuclear receptor RXR 0.007 0.0567 0.0853
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0045 0.0331 0.1225
Schistosoma mansoni hypothetical protein 0.0079 0.0656 0.0656
Brugia malayi hypothetical protein 0.0281 0.2559 0.3845
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0158 0.1394 0.1394
Brugia malayi Steroid receptor seven-up type 2 0.0132 0.1156 0.1738
Loa Loa (eye worm) hypothetical protein 0.0281 0.2559 0.3845
Trypanosoma brucei unspecified product 0.0019 0.0088 0.0327
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0062 0.0497 0.0497
Onchocerca volvulus 0.0062 0.0497 0.1734
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0251 0.0927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0032 0.0214 0.0321
Echinococcus granulosus protein kinase shaggy 0.0058 0.0451 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0132 0.1156 0.1738
Schistosoma mansoni coup transcription factor 0.0132 0.1156 0.1156
Echinococcus multilocularis endoplasmin 0.0031 0.02 0.02
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0433 0.16
Brugia malayi RNA binding protein 0.0715 0.6655 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0132 0.1156 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0132 0.1156 0.1156
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Brugia malayi 6-phosphofructokinase 0.0108 0.0924 0.1389
Brugia malayi nuclear receptor NHR-88 0.0062 0.0497 0.0747
Schistosoma mansoni nuclear hormone receptor 0.0132 0.1156 0.1156
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0451 0.1667
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0132 0.1156 0.1156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0096 0.0036
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0275 0.1018
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0182 0.0675
Toxoplasma gondii exonuclease III APE 0.0045 0.0331 0.1225
Brugia malayi CXXC zinc finger family protein 0.0028 0.0175 0.0263
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Brugia malayi hypothetical protein 0.007 0.0567 0.0853
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0088 0.0312
Trypanosoma brucei heat shock protein, putative 0.0039 0.0275 0.1018
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Trichomonas vaginalis set domain proteins, putative 0.023 0.2076 0.7677
Echinococcus multilocularis musashi 0.0032 0.0213 0.0213
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0251 0.0251
Giardia lamblia Grp94/Hsp90 0.0031 0.02 0.4445
Plasmodium falciparum endoplasmin, putative 0.0024 0.0133 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0723
Leishmania major basic transcription factor 3a, putative 0.0296 0.2704 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0743 0.1116
Schistosoma mansoni Smad4 0.0015 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Echinococcus multilocularis GPCR, family 2 0.0079 0.0656 0.0656
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0743 0.0743
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0132 0.1156 0.1156
Schistosoma mansoni hypothetical protein 0.0079 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Brugia malayi Endoplasmin precursor 0.0039 0.0275 0.0414
Mycobacterium ulcerans hypothetical protein 0.0028 0.0174 0.0723
Loa Loa (eye worm) hypothetical protein 0.006 0.0476 0.0715
Onchocerca volvulus 0.0062 0.0497 0.1734
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0251 0.0927
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0174 0.0642
Mycobacterium ulcerans hypothetical protein 0.0036 0.0251 0.1043
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0451 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0132 0.1156 0.1738
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Loa Loa (eye worm) hypothetical protein 0.0062 0.0497 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0132 0.1156 0.1738
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0433 0.16
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0062 0.0497 0.0497
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0158 0.1394 0.5154
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0451 0.1654
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0132 0.1156 0.1738
Plasmodium falciparum basic transcription factor 3b, putative 0.0296 0.2704 1
Echinococcus multilocularis FTZ F1 alpha 0.0132 0.1156 0.1156
Trypanosoma cruzi transcription factor btf3, putative 0.0296 0.2704 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0132 0.1156 0.1738
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Brugia malayi MH1 domain containing protein 0.0019 0.0086 0.0129
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0132 0.1156 0.1156
Brugia malayi nuclear hormone receptor family member nhr-6 0.0062 0.0497 0.0747
Entamoeba histolytica hypothetical protein 0.0296 0.2704 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0433 0.16
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0497 0.0497
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0924 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0924 0.3418
Schistosoma mansoni transient receptor potential channel 0.0096 0.0812 0.0812
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0132 0.1156 0.1156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0045 0.0331 0.1225
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0924 0.0924
Entamoeba histolytica hypothetical protein 0.0189 0.1695 0.6268
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0052 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0251 0.0377
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0058 0.0204
Mycobacterium tuberculosis Conserved protein 0.0036 0.0251 0.0808
Schistosoma mansoni hypothetical protein 0.01 0.0851 0.0851
Onchocerca volvulus 0.0036 0.0251 0.0875
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0229 0.0229
Echinococcus granulosus thyroid hormone receptor alpha 0.0062 0.0497 0.0497
Brugia malayi nuclear receptor RXR 0.0062 0.0497 0.0747
Brugia malayi 6-phosphofructokinase 0.0108 0.0924 0.1389
Loa Loa (eye worm) hypothetical protein 0.0032 0.0213 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Loa Loa (eye worm) beta-lactamase 0.0036 0.0251 0.0377
Schistosoma mansoni transient receptor potential channel 0.0063 0.0506 0.0506
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0189 0.1695 0.1695
Brugia malayi orphan nuclear receptor NR2E1 0.0062 0.0497 0.0747
Trichomonas vaginalis heat shock protein, putative 0.0031 0.02 0.0741
Plasmodium vivax heat shock protein, putative 0.0016 0.0058 0.0216
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0229 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.05 0.4624 0.6948
Echinococcus multilocularis transcription factor Dp 1 0.0091 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0088 0.0327
Schistosoma mansoni heat shock protein 0.0039 0.0275 0.0275
Mycobacterium tuberculosis Conserved protein 0.0036 0.0251 0.0808
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0174 0.0642
Brugia malayi heat shock protein 90 0.0039 0.0275 0.0414
Brugia malayi hypothetical protein 0.0036 0.0247 0.0371
Onchocerca volvulus 0.0132 0.1156 0.4036
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0186 0.0186
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0055 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0229 0.0344
Trypanosoma cruzi pantothenate kinase subunit, putative 0.001 0.0004 0.0016
Trichomonas vaginalis heat shock protein, putative 0.0031 0.02 0.0741
Echinococcus multilocularis nuclear receptor nhr 48 0.0062 0.0497 0.0497
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Brugia malayi isocitrate dehydrogenase 0.008 0.0663 0.0996
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0251 0.2712
Brugia malayi MH1 domain containing protein 0.0034 0.0229 0.0344
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0251 0.0927
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0132 0.1156 0.1738
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0107 0.5837
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0055 0.0055
Brugia malayi MH2 domain containing protein 0.05 0.4624 0.6948
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0045 0.0331 0.0331
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0506 0.0506
Brugia malayi Pre-SET motif family protein 0.003 0.0186 0.028
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.02 0.2168
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0275 0.6103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0377
Loa Loa (eye worm) transcription factor SMAD2 0.05 0.4624 0.6948
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0251 0.0808
Schistosoma mansoni smad1 5 8 and 0.0034 0.0229 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0186 0.0186
Brugia malayi Smad1 0.0034 0.0229 0.0344
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.2271 0.3413
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0451 0.1667
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0143 0.0143
Brugia malayi MH1 domain containing protein 0.0019 0.0086 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0924 0.1389
Onchocerca volvulus 0.0028 0.0175 0.0612
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0045 0.0331 0.1209
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0567 0.0853
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1156 0.1156
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0213 0.032
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.02 0.4445
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0924 0.3418
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0275 0.1018
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0182 0.0675
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0088 0.0088
Brugia malayi hypothetical protein 0.0056 0.0433 0.065
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0062 0.0497 0.0497
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0924 0.3418
Echinococcus granulosus lamin 0.0032 0.0213 0.0213
Schistosoma mansoni intermediate filament proteins 0.0032 0.0213 0.0213
Leishmania major heat shock protein, putative 0.0016 0.0058 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0433 0.16
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0182 0.0675
Loa Loa (eye worm) histone methyltransferase 0.001 0.0001 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0045 0.0331 0.1225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0174 0.0723
Loa Loa (eye worm) glutaminase 2 0.0265 0.2403 0.3611
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0229 0.0229
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0567 0.0853
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0058 0.0216
Loa Loa (eye worm) RNA binding protein 0.0715 0.6655 1
Brugia malayi Hsp90 protein 0.0016 0.0058 0.0088
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Brugia malayi Pre-SET motif family protein 0.0202 0.1813 0.2725
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0261
Onchocerca volvulus 0.0032 0.0213 0.0742
Plasmodium vivax endoplasmin, putative 0.0039 0.0275 0.1018
Trichomonas vaginalis heat shock protein, putative 0.0031 0.02 0.0741
Schistosoma mansoni tar DNA-binding protein 0.0715 0.6655 0.6655
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0052 0.0052
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0143 0.0143
Brugia malayi glutaminase DH11.1 0.0265 0.2403 0.3611
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0244 0.0244
Schistosoma mansoni heat shock protein 0.0016 0.0058 0.0058
Schistosoma mansoni smad 0.0015 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0497 0.0497
Schistosoma mansoni transcription factor btf3 0.0296 0.2704 0.2704
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Echinococcus granulosus intermediate filament protein 0.0032 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.016
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0088 0.0327
Leishmania major DNA polymerase kappa, putative 0.0019 0.0088 0.0312
Echinococcus granulosus Smad4 0.0034 0.0229 0.0229
Trypanosoma brucei unspecified product 0.0013 0.0032 0.012
Loa Loa (eye worm) hypothetical protein 0.0132 0.1156 0.1738
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0924 0.3407
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0924 0.3418
Brugia malayi beta-lactamase family protein 0.0036 0.0251 0.0377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0251 0.0808
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0052 0.0077
Schistosoma mansoni transient receptor potential channel 0.0063 0.0506 0.0506
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0924 0.0924
Echinococcus granulosus heat shock protein 0.0039 0.0275 0.0275
Echinococcus granulosus dna polymerase eta 0.0019 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0251 0.0808
Trypanosoma cruzi transcription factor btf3, putative 0.0296 0.2704 1
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0331 0.1225
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.2704 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0132 0.1156 0.1156
Brugia malayi MH2 domain containing protein 0.0034 0.0229 0.0344
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0506 0.0506
Leishmania major heat shock protein 83-1 0.0039 0.0275 0.1004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0132 0.1156 0.1156
Schistosoma mansoni smad 0.0034 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0327
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0451 0.0678
Schistosoma mansoni heat shock protein 0.0039 0.0275 0.0275

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.2 uM Displacement of [3H]SR141716A from CB1 receptor in Sprague-Dawley rat cerebellum membrane ChEMBL. 17582659
Inhibition (functional) = 58 % Agonist activity at CB1 receptor in electrically-stimulated Swiss mouse vas deferens at 1.0 uM ChEMBL. 17582659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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