Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0083 | 0.1212 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0083 | 0.1212 | 0.0326 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0083 | 0.1212 | 1 |
Brugia malayi | beta-lactamase | 0.0083 | 0.1212 | 0.3416 |
Trichomonas vaginalis | esterase, putative | 0.0083 | 0.1212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Mycobacterium leprae | Probable lipase LipE | 0.0083 | 0.1212 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0083 | 0.1212 | 0.0326 |
Loa Loa (eye worm) | beta-lactamase | 0.0083 | 0.1212 | 0.3416 |
Plasmodium vivax | hypothetical protein, conserved | 0.0083 | 0.1212 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0648 | 0.5345 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0648 | 0.5345 |
Brugia malayi | beta-lactamase family protein | 0.0083 | 0.1212 | 0.3416 |
Mycobacterium tuberculosis | Conserved protein | 0.0083 | 0.1212 | 0.0326 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0083 | 0.1212 | 0.0326 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0648 | 0.1826 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0083 | 0.1212 | 0.0326 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0083 | 0.1212 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0083 | 0.1212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.3547 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0083 | 0.1212 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0648 | 0.5345 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0915 | 0.7553 |
Onchocerca volvulus | 0.0083 | 0.1212 | 0.3416 | |
Mycobacterium ulcerans | hypothetical protein | 0.0083 | 0.1212 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0915 | 0.7553 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0083 | 0.1212 | 0.0326 |
Mycobacterium ulcerans | lipase LipD | 0.0083 | 0.1212 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0083 | 0.1212 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0083 | 0.1212 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0083 | 0.1212 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0648 | 0.5345 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0202 | 0.3547 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0083 | 0.1212 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0915 | 0.7553 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0083 | 0.1212 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0083 | 0.1212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0083 | 0.1212 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0083 | 0.1212 | 0.3416 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0083 | 0.1212 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.1212 | 0.3416 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0083 | 0.1212 | 0.0326 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0083 | 0.1212 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0083 | 0.1212 | 0.3416 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0083 | 0.1212 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0083 | 0.1212 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0648 | 0.1826 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0915 | 0.7553 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0648 | 0.5345 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0083 | 0.1212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1212 | 0.3416 |
Mycobacterium tuberculosis | Conserved protein | 0.0083 | 0.1212 | 0.0326 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0083 | 0.1212 | 0.0326 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0083 | 0.1212 | 0.3416 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0083 | 0.1212 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0648 | 0.5345 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0083 | 0.1212 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0648 | 0.5345 |
Onchocerca volvulus | 0.0083 | 0.1212 | 0.3416 | |
Brugia malayi | ecdysteroid receptor | 0.0202 | 0.3547 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 4.8 ug ml-1 | Cytotoxicity against mouse P388 cells | ChEMBL. | 2778450 |
ED50 (functional) | = 13 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 2778450 |
IC50 (functional) | > 10 ug ml-1 | Antileishmanial activity against Leishmania donovani LV82 promastigotes expressing red fluorescent protein after 72 hrs by flow cytometric analysis | ChEMBL. | 26905523 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 26905523 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.