Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0031 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0199 | 1 | 1 |
Brugia malayi | tailless protein | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0105 | 0.4399 | 0.4399 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0199 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0199 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0126 | 0.5633 | 0.5633 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0199 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0105 | 0.4399 | 0.4399 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0199 | 1 | 1 | |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0199 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0199 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2293 | 0.2293 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0199 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0031 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0199 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0199 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0199 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0031 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0199 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0094 | 0.3728 | 0.3728 |
Echinococcus granulosus | FTZ F1 alpha | 0.0199 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0075 | 0.2611 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0199 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | ecdysone receptor | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0199 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Brugia malayi | nuclear receptor NHR-88 | 0.0199 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0199 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.3368 | 0.3368 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0094 | 0.3728 | 0.3728 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0199 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0199 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0199 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | nuclear receptor RXR | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0031 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0199 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0199 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0094 | 0.3728 | 0.3728 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0105 | 0.4399 | 0.4399 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0199 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0199 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0031 | 0 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0105 | 0.4399 | 0.4399 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0126 | 0.5633 | 0.5633 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0199 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0199 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0199 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0199 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | steroid hormone receptor | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | DR-78 | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | nuclear hormone receptor | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0031 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.3368 | 0.3368 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.008 | 0.2927 | 0.2927 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0031 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.008 | 0.2927 | 0.2927 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0199 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0105 | 0.4399 | 0.4399 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0199 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0199 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0105 | 0.4399 | 0.4399 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0199 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0199 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0105 | 0.4399 | 0.4399 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | nuclear receptor RXR | 0.0105 | 0.4399 | 0.4399 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0199 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0094 | 0.3728 | 0.3728 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0075 | 0.2611 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0199 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.008 | 0.2927 | 0.2927 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0094 | 0.3728 | 0.3728 |
Brugia malayi | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0199 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0199 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | zinc finger protein | 0.0094 | 0.3728 | 0.3728 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | nuclear receptor | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | nuclear hormone receptor | 0.0094 | 0.3728 | 0.3728 |
Schistosoma mansoni | nuclear hormone receptor | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0094 | 0.3728 | 0.3728 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0094 | 0.3728 | 0.3728 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4399 | 0.4399 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0199 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.008 | 0.2927 | 0.2927 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0199 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.