Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0085 | 0.4705 | 0.6252 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0124 | 0.7525 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 0.0246 | 0.0246 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0085 | 0.4705 | 0.6252 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4705 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0159 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4705 | 0.4705 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Trypanosoma brucei | cytochrome P450, putative | 0.0066 | 0.3381 | 0.3381 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.3862 | 0.3862 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.7525 | 1 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.3862 | 0.3862 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | organic anion transporter | 0.0124 | 0.7525 | 0.7525 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0124 | 0.7525 | 0.7525 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0066 | 0.3381 | 1 |
Echinococcus multilocularis | expressed protein | 0.0085 | 0.4705 | 0.4705 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.0085 | 0.4705 | 0.4705 |
Onchocerca volvulus | Putative organic anion transporter | 0.0124 | 0.7525 | 1 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0246 | 0.0246 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0159 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.166 | 0.166 |
Leishmania major | cytochrome p450-like protein | 0.0066 | 0.3381 | 0.3381 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2015 | 0.2015 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0023 | 0.0246 | 0.0246 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0159 | 1 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0085 | 0.4705 | 0.4705 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0159 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.4705 | 0.6125 | |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.3862 | 0.3862 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.3862 | 0.3862 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 0.0246 | 0.0246 |
Onchocerca volvulus | Putative organic anion transporter | 0.0124 | 0.7525 | 1 |
Brugia malayi | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0066 | 0.3381 | 0.3381 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0066 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | agrin | 0.0085 | 0.4705 | 0.4705 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0 | 0.5 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0159 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0085 | 0.4705 | 0.6252 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.3381 | 0.3381 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.3862 | 0.3862 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 0.0246 | 0.0246 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | follistatin | 0.0085 | 0.4705 | 0.4705 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0124 | 0.7525 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0085 | 0.4705 | 0.4705 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.3862 | 0.3862 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | prostaglandin transporter | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.3381 | 0.3381 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4705 | 0.4705 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.0085 | 0.4705 | 0.4705 |
Onchocerca volvulus | 0.0124 | 0.7525 | 1 | |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0 | 0.5 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0085 | 0.4705 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0124 | 0.7525 | 0.7525 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0159 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0246 | 0.0246 |
Toxoplasma gondii | protease inhibitor PI2 | 0.0085 | 0.4705 | 0.6252 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0159 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0246 | 0.0246 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0066 | 0.3381 | 0.3381 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Echinococcus multilocularis | agrin | 0.0085 | 0.4705 | 0.4705 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.3381 | 0.3381 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0159 | 1 | 1 |
Onchocerca volvulus | 0.0124 | 0.7525 | 1 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | agrin | 0.0085 | 0.4705 | 0.4705 |
Schistosoma mansoni | follistatin | 0.0085 | 0.4705 | 0.4705 |
Trypanosoma cruzi | MFS transporter, putative | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0085 | 0.4705 | 0.6252 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0085 | 0.4705 | 0.4705 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.3862 | 0.3862 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.7525 | 0.7525 |
Brugia malayi | SPARC precursor | 0.0085 | 0.4705 | 0.4705 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0124 | 0.7525 | 1 | |
Schistosoma mansoni | organic anion transporter | 0.0124 | 0.7525 | 0.7525 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.3862 | 0.3862 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0085 | 0.4705 | 0.4705 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.3862 | 0.3862 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | follistatin | 0.0085 | 0.4705 | 0.4705 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0246 | 0.0246 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4705 | 0.4705 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.166 | 0.166 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0246 | 0.0246 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0124 | 0.7525 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0159 | 1 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0159 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0159 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0159 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.