Plasmodium protease targets

Posted by Stuart Ralph on 2007-08-03 13:27:35

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

A list of potential Plasmodium protease drug targets.
*NB Relies on the word "protease" or "peptidase" appearing in gene name to identify proteases - maybe also possible with EC numbers?

The weighting is
In Plasmodium, has a name like “peptidase”: 100
In Plasmodium, has a name like “protease”: 100
has literature: 30
has modelled or solved structure: 50
druggability >0.3: 50
no orthologues in mammals: 50
essential in some organism: 30

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Union of (#1, #2, #3, #4, #5, #6, #9) (5293 records), 3
    • Score for genes in query #9 (plasmodium protease): 100
    • Score for genes in query #1 (plasmodium peptidase): 100
    • Score for genes in query #2 (has structure): 50
    • Score for genes in query #3 (not in mammals): 50
    • Score for genes in query #5 (druggability >0.3): 50
    • Score for genes in query #4 (essential somewhere): 30
    • Score for genes in query #6 (literature): 30