A Ranked List of T. cruzi Targets

Posted by Fernan Aguero on 2009-03-24 20:01:13

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

I have run a number of queries using different criteria to
retrieve T. cruzi genes.

Each query filters genes based on a single criteria.

These are:
* gene does not have orthologs in human/mouse [50]
* gene has orthologs in T. brucei [40]
* gene has orthologs in Yeast that are essential [50]
* gene has orthologs in Bacteria (E. coli, M. tuberculosis)
that are essential [40]
* gene has 3D Model(s) [30]
* gene has 3D structure(s) [40]
* gene has a druggability index > 0.6 (0-1 scale) [40]

A ranked list of genes was produced by asking for the UNION
of the above queries and assigning a weight (score) to each query
(in square brackets above).

Feel free to use this set, add/remove queries, revise my scoring scheme,
etc. And do share back your revised sets!

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy