Reweightable Leish 12-criteria query and components thereof

Posted by Greg Crowther on 2009-03-26 15:57:12

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

This is an update of a previously published query set, done mostly to take advantage of the reweighting feature option in the new database (version 3). The criteria remain the same as before, i.e., enzymes (100), MW < 100 kDa (20), no TM domains (20), PDB structure (50), Modbase model (30), present in all TriTryps (25), not in humans (25), essential in at least one model organism (40), genetic validation in Leishmania (50), druggability > 0.6 (35), compound desirability > 0.3 (35), and PubMed publications (35).

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Leish enzymes (2100 records), 3
    • Is enzyme: Y
    • Species: lma
  • Leish < 100 kDa (7732 records), 3
    • Molecular weight: < 100000
    • Species: lma
  • Leish no transmembrane domains (7645 records), 3
    • Number of TM segments: = 0
    • Species: lma
  • Leish PDB structure (61 records), 3
    • Structures: PDB
    • Species: lma
  • Leish structural model (ModBase) (3973 records), 3
    • Structures: Modbase
    • Species: lma
  • Leish present in all TriTryps (6237 records), 3
    • Species: lma
    • Phylogenetic distribution: IN tcr, IN lma, IN tbr
  • Leish not in humans (2562 records), 3
    • Species: lma
    • Phylogenetic distribution: IN hsa
  • Leish essential (1482 records), 3
    • Species: lma
    • Essential: Any
  • Leish genetic validation (77 records), 3
    • Genetic validation: any
    • Species: lma
  • Leish druggability > 0.6 (230 records), 3
    • Druggability evidence index: > 0.6
    • Species: lma
  • Leish compound desirability > 0.3 (182 records), 3
    • Species: lma
    • Compound desirability index: > 0.3
  • Leish PubMed publications (459 records), 3
    • Pubmed: any
    • Species: lma
  • Reweightable Leish rankings (12 criteria) (9184 records), 3
    • Score for genes in query #341 (Leish structural model (ModBase)): 30
    • Score for genes in query #346 (Leish druggability > 0.6): 35
    • Score for genes in query #347 (Leish compound desirability > 0.3): 35
    • Score for genes in query #348 (Leish PubMed publications): 35
    • Score for genes in query #345 (Leish genetic validation): 50
    • Score for genes in query #339 (Leish no transmembrane domains): 20
    • Score for genes in query #342 (Leish present in all TriTryps): 25
    • Score for genes in query #343 (Leish not in humans): 25
    • Score for genes in query #340 (Leish PDB structure): 50
    • Score for genes in query #337 (Leish enzymes): 100
    • Score for genes in query #338 (Leish < 100 kDa): 20
    • Score for genes in query #344 (Leish essential): 40