Brugia genome prioritization - druggability inferred by sequence similarity

Posted by Santiago Carmona on 2009-06-21 00:52:26

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

A prioritization session mainly based on phenotypes observed in C. elegans,
absence in human and mouse and druggability (inferred by sequence similarity against known druggable targets,
uploaded list)
Initial Criteria:

Score for genes in query #10 (Sterility in C. elegans): 20
Score for genes in query #11 (3D model available): 2
Score for genes in query #12 (enzyme): 10
Score for genes in query #13 (bibliographic reference): 2
Score for genes in query #2 (in human): -40
Score for genes in query #3 (in mouse): -20
Score for genes in query #4 (in C. elegans): 10
Score for genes in query #5 (any essentiality evidence): 5
Score for genes in query #6 (Embryonic Lethal/Arrest in C. elegans): 30
Score for genes in query #7 (Growth Defect in C. elegans): 20
Score for genes in query #8 (Larval/Adult Lethal/Arrest in C. elegans): 40
Score for genes in query #9 (Morphology Defect in C. elegans): 20
Score for genes in query #19 (druggable genes inferred by sequence simiarity): 30

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • in human (5653 records), 3
    • Species: bma
    • Phylogenetic distribution: IN hsa
  • in mouse (5420 records), 3
    • Phylogenetic distribution: IN mmu
    • Species: bma
  • in C. elegans (7260 records), 3
    • Species: bma
    • Phylogenetic distribution: IN cel
  • any essentiality evidence (3227 records), 3
    • Essential: Any
    • Species: bma
  • Embryonic Lethal/Arrest in C. elegans (2284 records), 3
    • Essential: cel Embryonic Lethal/Arrest
    • Species: bma
  • Growth Defect in C. elegans (1104 records), 3
    • Species: bma
    • Essential: cel Growth Defect
  • Larval/Adult Lethal/Arrest in C. elegans (1421 records), 3
    • Essential: cel Larval/Adult Lethal/Arrest
    • Species: bma
  • Morphology Defect in C. elegans (714 records), 3
    • Essential: cel Morphology Defect
    • Species: bma
  • Sterility in C. elegans (1461 records), 3
    • Species: bma
    • Essential: cel Sterility
  • 3D model available (7870 records), 3
    • Structures: PDB or Modbase
    • Species: bma
  • enzyme (637 records), 3
    • EC: *
    • Species: bma
  • bibliographic reference (212 records), 3
    • Pubmed: any
    • Species: bma
  • druggable genes inferred by sequence simiarity (815 records), 3
    • Query: Uploaded list
  • Union of (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 19) (9068 records), 3
    • Score for genes in query #19 (druggable genes inferred by sequence simiarity): 30
    • Score for genes in query #3 (in mouse): -20
    • Score for genes in query #9 (Morphology Defect in C. elegans): 20
    • Score for genes in query #8 (Larval/Adult Lethal/Arrest in C. elegans): 40
    • Score for genes in query #7 (Growth Defect in C. elegans): 20
    • Score for genes in query #11 (3D model available): 2
    • Score for genes in query #5 (any essentiality evidence): 5
    • Score for genes in query #12 (enzyme): 10
    • Score for genes in query #13 (bibliographic reference): 2
    • Score for genes in query #4 (in C. elegans): 10
    • Score for genes in query #6 (Embryonic Lethal/Arrest in C. elegans): 30
    • Score for genes in query #2 (in human): -40
    • Score for genes in query #10 (Sterility in C. elegans): 20