Ranked list of L. major targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-04 23:51:24

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Genomic scale ranking of L. major genes demonstrating that combining a wide range of criteria can be quiet useful in target prioritization work. Using this set of queries two different lists were generated - one without including essentiality data and another including essentiality data.


Score for genes in query #100 (Lma modbase): 30
Score for genes in query #101 (Lma not in humans): 25
Score for genes in query #102 (Lma any genetic validation): 50
Score for genes in query #103 (Lma any essentiality evidence): 50
Score for genes in query #104 (Lma dindex >=0.6): 35
Score for genes in query #105 (Lma Compd desirability >0.3): 35
Score for genes in query #106 (Lma assayable): 35
Score for genes in query #107 (Lma all proteins): 1
Score for genes in query #110 (Lma in Tbr and Tcr): 25
Score for genes in query #95 (Lma enz (EC + func. Categ.)): 100
Score for genes in query #96 (Lma Pubmed): 35
Score for genes in query #97 (Lma mwt <100kDa): 20
Score for genes in query #98 (Lma no TM domain): 20
Score for genes in query #99 (Lma PDB): 50

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Lma enzyme (EC + functional category) (1228 records), 3
    • EC: any
    • Is enzyme: Y
    • Species: lma
  • Lma Pubmed (695 records), 3
    • Species: lma
    • Pubmed: any
  • Lma Molecular weight <100kDa (3942 records), 3
    • Molecular weight: < 100000
    • Species: lma
  • Lma no TM domain (3197 records), 3
    • Number of TM segments: = 0
    • Species: lma
  • Lma PDB structure (253 records), 3
    • Structures: PDB
    • Species: lma
  • Lma Modbase structure model (2756 records), 3
    • Species: lma
    • Structures: Modbase
  • Lma not in humans (3310 records), 3
    • Phylogenetic distribution: NOT IN hsa
    • Species: lma
  • Lma any genetic validation (28 records), 3
    • Species: lma
    • Genetic validation: any
  • Lma any essentiality (1054 records), 3
    • Species: lma
    • Essential: Any
  • Lma Dindex >=0.6 (16 records), 3
    • Druggability evidence index: >= 0.6
    • Species: lma
  • Lma Compound desirability >0.3 (103 records), 3
    • Species: lma
    • Compound desirability index: > 0.3
  • Lma assayable (254 records), 3
    • Species: lma
    • Assay available: Yes
  • Lma all proteins (3999 records), 3
    • Species: lma
    • Protein length: > 0
  • Lma in taxon (Tbr & Tcr) (6237 records), 3
    • Phylogenetic distribution: IN tcr, IN tbr
    • Species: lma
  • Weighted ranking of L. major targets for PLOS-NTD (9222 records), 3
    • Score for genes in query #103 (Mtb any essentiality evidence (now searched on lma)): 50
    • Score for genes in query #96 (Mtb Pubmed (now searched on lma)): 35
    • Score for genes in query #110 (Lma in Tbr and Tcr): 25
    • Score for genes in query #95 (Mtb enz (EC + func. Categ.) (now searched on lma)): 100
    • Score for genes in query #102 (Mtb any genetic validation (now searched on lma)): 50
    • Score for genes in query #100 (Mtb modbase (now searched on lma)): 30
    • Score for genes in query #98 (Mtb no TM domain (now searched on lma)): 20
    • Score for genes in query #105 (Mtb Compd desirability >0.3 (now searched on lma)): 35
    • Score for genes in query #101 (Mtb not in humans (now searched on lma)): 25
    • Score for genes in query #106 (Mtb assayable (now searched on lma)): 35
    • Score for genes in query #104 (Mtb dindex >=0.6 (now searched on lma)): 35
    • Score for genes in query #99 (Mtb PDB (now searched on lma)): 50
    • Score for genes in query #97 (Mtb mwt <100kDa (now searched on lma)): 20
    • Score for genes in query #107 (Mtb all proteins (now searched on lma)): 1
  • Weighted ranking (excluding essentiality) of L. major targets for PLOS-NTD (9222 records), 3
    • Score for genes in query #101 (Mtb not in humans (now searched on lma)): 25
    • Score for genes in query #106 (Mtb assayable (now searched on lma)): 35
    • Score for genes in query #110 (Lma in Tbr and Tcr): 25
    • Score for genes in query #96 (Mtb Pubmed (now searched on lma)): 35
    • Score for genes in query #100 (Mtb modbase (now searched on lma)): 30
    • Score for genes in query #98 (Mtb no TM domain (now searched on lma)): 20
    • Score for genes in query #105 (Mtb Compd desirability >0.3 (now searched on lma)): 35
    • Score for genes in query #95 (Mtb enz (EC + func. Categ.) (now searched on lma)): 100
    • Score for genes in query #102 (Mtb any genetic validation (now searched on lma)): 50
    • Score for genes in query #107 (Mtb all proteins (now searched on lma)): 1
    • Score for genes in query #99 (Mtb PDB (now searched on lma)): 50
    • Score for genes in query #104 (Mtb dindex >=0.6 (now searched on lma)): 35
    • Score for genes in query #97 (Mtb mwt <100kDa (now searched on lma)): 20