Ranked list of P. falciparum targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-05 11:30:53

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Genomic scale ranking of P. falciparum genes using the same set of queries that were used for the L. major list. This demonstrates that the same set of queries may be used to rank targets in various pathogens.

Score for genes in query #78 (Pfa enz (EC + func. Categ.)): 100
Score for genes in query #79 (Pfa Pubmed): 35
Score for genes in query #80 (Pfa mwt <100kDa): 20
Score for genes in query #81 (Pfa no TM domain): 20
Score for genes in query #82 (Pfa PDB): 50
Score for genes in query #83 (Pfa modbase): 30
Score for genes in query #84 (Pfa not in humans): 25
Score for genes in query #85 (Pfa any genetic validation): 50
Score for genes in query #86 (Pfa any essentiality evidence): 50
Score for genes in query #87 (Pfa dindex >=0.6): 35
Score for genes in query #88 (Pfa Compd desirability >0.3): 35
Score for genes in query #89 (Pfa assayable): 35
Score for genes in query #90 (Pfa all proteins): 1
Score for genes in query #93 (Pfa in Pvi): 25

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Pfa enzyme (EC + functional category) (1228 records), 3
    • EC: any
    • Is enzyme: Y
    • Species: pfa
  • Pfa in Pubmed (695 records), 3
    • Pubmed: any
    • Species: pfa
  • Pfa molecular weight <100kDa (3942 records), 3
    • Molecular weight: < 100000
    • Species: pfa
  • Pfa no TM domain (3197 records), 3
    • Number of TM segments: = 0
    • Species: pfa
  • Pfa PDB structure (253 records), 3
    • Species: pfa
    • Structures: PDB
  • Pfa Modbase structure model (2756 records), 3
    • Structures: Modbase
    • Species: pfa
  • Mtb not in humans (now searched on pfa) (3310 records), 3
    • Phylogenetic distribution: NOT IN hsa
    • Species: pfa
  • Pfa any genetic validation (28 records), 3
    • Genetic validation: any
    • Species: pfa
  • Pfa any essentiality (1054 records), 3
    • Essential: Any
    • Species: pfa
  • Pfa Dindex >=0.6 (16 records), 3
    • Species: pfa
    • Druggability evidence index: >= 0.6
  • Pfa Compound desirability >0.3 (103 records), 3
    • Compound desirability index: > 0.3
    • Species: pfa
  • Pfa assayable (254 records), 3
    • Assay available: Yes
    • Species: pfa
  • Pfa all proteins (3999 records), 3
    • Protein length: > 0
    • Species: pfa
  • Pfa ortholog in taxon (Pvi) (4540 records), 3
    • Phylogenetic distribution: IN pvi
    • Species: pfa
  • Weighted ranking of Pfa targets for PLOS-NTD (5590 records), 3
    • Score for genes in query #88 (Mtb Compd desirability >0.3 (now searched on pfa)): 35
    • Score for genes in query #82 (Mtb PDB (now searched on pfa)): 50
    • Score for genes in query #81 (Mtb no TM domain (now searched on pfa)): 20
    • Score for genes in query #83 (Mtb modbase (now searched on pfa)): 30
    • Score for genes in query #93 (Pfa in Pvi): 25
    • Score for genes in query #89 (Mtb assayable (now searched on pfa)): 35
    • Score for genes in query #86 (Mtb any essentiality evidence (now searched on pfa)): 50
    • Score for genes in query #84 (Mtb not in humans (now searched on pfa)): 25
    • Score for genes in query #78 (Mtb enz (EC + func. Categ.) (now searched on pfa)): 100
    • Score for genes in query #79 (Mtb Pubmed (now searched on pfa)): 35
    • Score for genes in query #87 (Mtb dindex >=0.6 (now searched on pfa)): 35
    • Score for genes in query #85 (Mtb any genetic validation (now searched on pfa)): 50
    • Score for genes in query #90 (Mtb all proteins (now searched on pfa)): 1
    • Score for genes in query #80 (Mtb mwt <100kDa (now searched on pfa)): 20