Ranked list of M. tuberculosis targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-05 11:39:23

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Genomic scale ranking of M. tuberculosis genes using the same set of queries that were used for the L. major list. This demonstrates that the same set of queries may be used to rank targets in various pathogens.

Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100
Score for genes in query #61 (Mtb Pubmed): 35
Score for genes in query #62 (Mtb mwt <100kDa): 20
Score for genes in query #63 (Mtb no TM domain): 20
Score for genes in query #64 (Mtb PDB): 50
Score for genes in query #65 (Mtb modbase): 30
Score for genes in query #66 (Mtb not in humans): 25
Score for genes in query #67 (Mtb in Mle): 25
Score for genes in query #68 (Mtb any genetic validation): 50
Score for genes in query #69 (Mtb any essentiality evidence): 50
Score for genes in query #70 (Mtb dindex >=0.6): 35
Score for genes in query #71 (Mtb Compd desirability >0.3): 35
Score for genes in query #72 (Mtb assayable): 35
Score for genes in query #74 (Mtb all proteins): 1

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Mtb enzyme (EC + functional category) (1228 records), 3
    • EC: any
    • Is enzyme: Y
    • Species: mtu
  • Mtb Pubmed (695 records), 3
    • Species: mtu
    • Pubmed: any
  • Mtb mwt <100kDa (3942 records), 3
    • Molecular weight: < 100000
    • Species: mtu
  • Mtb no TM domain (3197 records), 3
    • Species: mtu
    • Number of TM segments: = 0
  • Mtb PDB structure (253 records), 3
    • Structures: PDB
    • Species: mtu
  • Mtb modbase structure model (2756 records), 3
    • Species: mtu
    • Structures: Modbase
  • Mtb not in humans (3310 records), 3
    • Phylogenetic distribution: NOT IN hsa
    • Species: mtu
  • Mtb ortholog in taxon (Mle) (1582 records), 3
    • Species: mtu
    • Phylogenetic distribution: IN mle
  • Mtb any genetic validation (28 records), 3
    • Species: mtu
    • Genetic validation: any
  • Mtb any essentiality evidence (1054 records), 3
    • Essential: Any
    • Species: mtu
  • Mtb dindex >=0.6 (16 records), 3
    • Species: mtu
    • Druggability evidence index: >= 0.6
  • Mtb Compd desirability >0.3 (103 records), 3
    • Species: mtu
    • Compound desirability index: > 0.3
  • Mtb assayable (254 records), 3
    • Assay available: Yes
    • Species: mtu
  • Mtb all proteins (3999 records), 3
    • Protein length: > 0
    • Species: mtu
  • Weighted ranking of Mtb targets for PLOS-NTD (4049 records), 3
    • Score for genes in query #69 (Mtb any essentiality evidence): 50
    • Score for genes in query #61 (Mtb Pubmed): 35
    • Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100
    • Score for genes in query #74 (Mtb all proteins): 1
    • Score for genes in query #62 (Mtb mwt <100kDa): 20
    • Score for genes in query #63 (Mtb no TM domain): 20
    • Score for genes in query #65 (Mtb modbase): 30
    • Score for genes in query #68 (Mtb any genetic validation): 50
    • Score for genes in query #70 (Mtb dindex >=0.6): 35
    • Score for genes in query #67 (Mtb in Mle): 25
    • Score for genes in query #72 (Mtb assayable): 35
    • Score for genes in query #71 (Mtb Compd desirability >0.3): 35
    • Score for genes in query #64 (Mtb PDB): 50
    • Score for genes in query #66 (Mtb not in humans): 25