Ranked list of S.mansoni targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-10-10 12:39:56

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Genomic scale ranking of S. mansoni genes emphasizing phenotype, expression, curation and druggable data.

Score for genes in query #208 (Sma EC numbers - uploaded list): 10
Score for genes in query #209 (Orthologs of D. melanogaster genes with mutant phenotype lethal): 10
Score for genes in query #210 (Orthologs of D. melanogaster genes with mutant phenotype neurophysiological defect): 10
Score for genes in query #211 (Embryonic Lethal/Arrest in C. elegans): 10
Score for genes in query #212 (Growth Defect in C. elegans): 3
Score for genes in query #213 (Larval/Adult Lethal/Arrest in C. elegans): 10
Score for genes in query #214 (Morphology Defect in C. elegans): 3
Score for genes in query #215 (Sterility in C. elegans): 3
Score for genes in query #216 (any essentiality evidence): 3
Score for genes in query #217 (structural model available): 10
Score for genes in query #218 (druggable genes inferred by sequence simiarity): 10
Score for genes in query #219 (expressed in adult worm (ESTs)): 3
Score for genes in query #220 ( expressed in egg stage (ESTs)): 3
Score for genes in query #221 ( expressed in schistosomula stage (ESTs)): 3
Score for genes in query #222 (expressed in any relevant stage (ESTs)): 10
Score for genes in query #223 (Sma all proteins): 1
Score for genes in query #225 (Sma in Cel): 10
Score for genes in query #226 (Sma uploaded list of metabolic chokepoint enzymes (Berriman et al, 2009)): 10
Score for genes in query #227 (Sma uploaded list of targets identified by STARlite search (Berriman et al, 2009)): 10
Score for genes in query #228 (Sma uploaded list of targets similar to known human targets (Berriman et al, 2009)): 10

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy