Posted by Fernan Aguero on 2010-04-13 13:21:09
T. cruzi targets that are also present in Leishmania, but that are absent in T. brucei.
The prioritization strategy includes some other general (basic) attributes, apart from the phylogenetic ones, as described below:
Query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
Query #10 (tcruzi all genes): 1
Query #11 (tcruzi not in humans): 80
Query #12 (tcruzi in leish): 90
Query #13 (tcruzi not in tbrucei): 150
Query #14 (tcruzi reagent availability): 30
Query #15 (tcruzi assay available): 30
Query #2 (is enzyme): 20
Query #3 (3D structure): 10
Query #4 (3D model): 10
Query #5 (any evidence of essentiality): 50
Query #6 (> 3 paralogs): -30
Query #7 (druggability > .5): 60
Query #8 (bibrefs): 25
Query #9 (low molecular weight (< 100 kDa)): 25