Ranked list of B. malayi targets for PLOS-NTD2

Posted by Dany Shanmugam on 2010-04-21 06:55:24

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Genomic scale ranking of B. malayi genes emphasizing phenotype and druggable data (mapped by orthology)

Score for genes in query #1 (Bma - sterile in Cel): 20
Score for genes in query #10 (Bma - morphology defect in Cel): 20
Score for genes in query #11 (Bma any essentiality): 5
Score for genes in query #12 (Bma precedence for being druggalable): 30
Score for genes in query #14 (Bma any EC): 10
Score for genes in query #15 (Bma in PDB): 5
Score for genes in query #16 (Bma assayable): 5
Score for genes in query #17 (Bma all proteins): 1
Score for genes in query #2 (Bma modbase): 2
Score for genes in query #4 (Bma pubmed): 2
Score for genes in query #5 (Bma in Cel): 10
Score for genes in query #7 (Bma - embryonic lethal/arrest in Cel): 30
Score for genes in query #8 (Bma - growth defect in Cel): 20
Score for genes in query #9 (Bma - larval/adult lethal/arrest in Cel): 40

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Bma druggable precedence by similarity to starlite targets (806 records), 3
    • Query: Uploaded list
  • Bma - sterile in Cel (1461 records), 3
    • Species: bma
    • Essential: cel Sterility
  • Bma modbase (7870 records), 3
    • Species: bma
    • Structures: Modbase
  • Bma pubmed (212 records), 3
    • Species: bma
    • Pubmed: any
  • Bma in Cel (7260 records), 3
    • Species: bma
    • Phylogenetic distribution: IN cel
  • Bma - embryonic lethal/arrest in Cel (2284 records), 3
    • Species: bma
    • Essential: cel Embryonic Lethal/Arrest
  • Bma - growth defect in Cel (1104 records), 3
    • Essential: cel Growth Defect
    • Species: bma
  • Bma - larval/adult lethal/arrest in Cel (1421 records), 3
    • Species: bma
    • Essential: cel Larval/Adult Lethal/Arrest
  • Bma - morphology defect in Cel (714 records), 3
    • Essential: cel Morphology Defect
    • Species: bma
  • Bma any essentiality (3227 records), 3
    • Species: bma
    • Essential: Any
  • Bma any EC (637 records), 3
    • Species: bma
    • EC: any
  • Bma in PDB (1 record), 3
    • Species: bma
    • Structures: PDB
  • Bma assayable (29 records), 3
    • Species: bma
    • Assay available: Yes
  • Bma all proteins (11508 records), 3
    • Species: bma
    • Protein length: > 0
  • Weighted ranking of B. malayi targets for PLOS-NTD (11508 records), 3
    • Score for genes in query #305 (Bma modbase): 2
    • Score for genes in query #10 (Bma druggable precedence by similarity to starlite targets): 30
    • Score for genes in query #311 (Bma - morphology defect in Cel): 20
    • Score for genes in query #316 (Bma assayable): 5
    • Score for genes in query #310 (Bma - larval/adult lethal/arrest in Cel): 40
    • Score for genes in query #304 (Bma - sterile in Cel): 20
    • Score for genes in query #307 (Bma in Cel): 10
    • Score for genes in query #312 (Bma any essentiality): 5
    • Score for genes in query #309 (Bma - growth defect in Cel): 20
    • Score for genes in query #317 (Bma all proteins): 1
    • Score for genes in query #308 (Bma - embryonic lethal/arrest in Cel): 30
    • Score for genes in query #314 (Bma any EC): 10
    • Score for genes in query #306 (Bma pubmed): 2
    • Score for genes in query #315 (Bma in PDB): 5