L. major queries for PLoS NTD Fig. 1

Posted by Greg Crowther on 2010-06-02 21:55:10

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

L. major queries being "published" so Fernan can access them in revising Fig. 1 for PLoS NTD.

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • all L. major proteins (8317 records), 3
    • Species: lma
    • Protein length: > 0
  • L. major enzymes (2100 records), 3
    • Is enzyme: Y
    • Species: lma
  • L. major PubMed publications (459 records), 3
    • Species: lma
    • Pubmed: any
  • L. major MW < 100 kD (7732 records), 3
    • Species: lma
    • Molecular weight: < 100000
  • L. major no transmembrane domains (7645 records), 3
    • Species: lma
    • Number of TM segments: = 0
  • L. major PDB structures (61 records), 3
    • Structures: PDB
    • Species: lma
  • L. major ModBase models (3973 records), 3
    • Species: lma
    • Structures: Modbase
  • L. major not in humans (6660 records), 3
    • Phylogenetic distribution: NOT IN hsa
    • Species: lma
  • L. major conserved in TriTryps (6237 records), 3
    • Species: lma
    • Phylogenetic distribution: IN tcr, IN lma, IN tbr
  • L. major genetic validation (77 records), 3
    • Genetic validation: any
    • Species: lma
  • L. major druggability >=0.6 (230 records), 3
    • Species: lma
    • Druggability evidence index: >= 0.6
  • L. major compound desirability > 0.3 (182 records), 3
    • Species: lma
    • Compound desirability index: > 0.3
  • L. major assayability precedent (315 records), 3
    • Species: lma
    • Assay available: Yes
  • PLoS NTD query (L. major) (9222 records), 3
    • Score for genes in query #528 (L. major ModBase models): 30
    • Score for genes in query #532 (L. major druggability >=0.6): 35
    • Score for genes in query #530 (L. major conserved in TriTryps): 25
    • Score for genes in query #527 (L. major PDB structures): 50
    • Score for genes in query #526 (L. major no transmembrane domains): 20
    • Score for genes in query #534 (L. major assayability precedent): 35
    • Score for genes in query #522 (all L. major proteins): 1
    • Score for genes in query #529 (L. major not in humans): 25
    • Score for genes in query #525 (L. major MW < 100 kD): 20
    • Score for genes in query #524 (L. major PubMed publications): 35
    • Score for genes in query #523 (L. major enzymes): 100
    • Score for genes in query #531 (L. major genetic validation): 50