[tcruzi] targets ranked by nucleotide diversity (TcSNP)

Posted by Fernan Aguero on 2012-07-03 17:06:05

List description

This is a prioritization exercise for the T. cruzi genome, where genetic polymorphism data (SNPs) has been used to increase the score of targets that are under apparent purifying selection, and at the same time penalize those that show more genetic diversity.

This query set represents the supplementary data for: Ackermann AA, Panunzi LG, Cosentino RO, Sanchez DO, and Aguero F (submitted).

Score for genes in query #49 (tcr expression epis-amas 1,5 fold 0.8 confidence): 12
Score for genes in query #50 (tcr expression trypos-amas 1,5 fold 0.8 confidence): 12
Score for genes in query #52 (tcr has ortholog in kinetoplastida): 9
Score for genes in query #55 (tcr doesn't have ortholog in mammals): 12
Score for genes in query #56 (Assayability - Assay Available): 7
Score for genes in query #57 (Assayability - Soluble): 7
Score for genes in query #58 (Pubmed): 12
Score for genes in query #59 (tcr MW < 100 kDa): 9
Score for genes in query #60 (has >= 1 TM domain): -3
Score for genes in query #61 (tcr > 2 paralogs): -18
Score for genes in query #62 (has GPI anchor signal): -3
Score for genes in query #63 (has Signal Peptide): -3
Score for genes in query #64 (has EC number): 9
Score for genes in query #67 (ortholog essential in E. coli): 12
Score for genes in query #68 (ortholog essential in M. tuberculosis): 12
Score for genes in query #69 (ortholog essential in S. cerevisiae): 12
Score for genes in query #70 (ortholog in C. elegans has 'embryonic arrest' RNAi phenotype): 12
Score for genes in query #71 (is enzyme): 15
Score for genes in query #72 (has 3D model(s)): 20
Score for genes in query #73 (has 3D structure(s)): 20
Score for genes in query #81 (nucleotide-diversity-normalized): var (function)

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy