SN 1

Posted by Solomon Nwaka on 2007-06-07 00:52:49

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

P. falciparum targets generated based on weighted queries on structure, phylogeny, essentilaity and druggability. 4 queries were run with intersection and union of queries.

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Intersection of (#1, #2, #7, #8) (2 records), 3
    • Score for genes in query #7 (Plasmodium falciparum genes with druggability index higher than 0.7):
    • Score for genes in query #1 (Plasmodium falciparum enzymes with structure):
    • Score for genes in query #2 (Plasmodium falciparum genes present in parasites and yeast but absent in animals):
    • Score for genes in query #8 (Plamodium falciparum genes with any essentiality ):
  • Union of (#1, #2, #7, #8) (1560 records), 3
    • Score for genes in query #7 (Plasmodium falciparum genes with druggability index higher than 0.7): 40
    • Score for genes in query #2 (Plasmodium falciparum genes present in parasites and yeast but absent in animals): 20
    • Score for genes in query #8 (Plamodium falciparum genes with any essentiality ): 50
    • Score for genes in query #1 (Plasmodium falciparum enzymes with structure): 10
  • Plasmodium falciparum enzymes with structure (564 records), 3
    • species: pfa
    • structures: PDB or Modbase
    • EC: any
  • Plasmodium falciparum genes present in parasites and yeast but absent in animals (164 records), 3
    • species: pfa
    • phylogenetic_distribution: NOT IN mmu, IN tcr, IN sce, NOT IN dme, NOT IN hsa, NOT IN cel, IN eco, IN lma, IN tbr, IN mtu
  • Plasmodium falciparum genes with druggability index higher than 0.7 (119 records), 3
    • species: pfa
    • druggability_index: > 0.7
  • Plamodium falciparum genes with any essentiality (1162 records), 3
    • essential: Any
    • species: pfa